Click here to switch to the map view.

The map label for this gene is alsR [H]

Identifier: 154244805

GI number: 154244805

Start: 953968

End: 954894

Strand: Reverse

Name: alsR [H]

Synonym: Xaut_0855

Alternate gene names: 154244805

Gene position: 954894-953968 (Counterclockwise)

Preceding gene: 154244816

Following gene: 154244798

Centisome position: 17.99

GC content: 67.1

Gene sequence:

>927_bases
ATGACTTATGCCATTTGTGATATGAATGTACCCATGCGCTTCGACCTCCGCCACGTCCGTGCCTTCGTCCTCCTGTCGGA
GGAACTGCACTTCAGCCGCGCCGCCCAGCGCGCCCACATGACCCAGCCGGCCATGAGCCGCCTGATCCGCGACCTGGAAC
AGGACGTGGGCGTGCCGCTGATCGCCCGCACCACGCGCTCGGTGGAACTGACCGAGGCCGGCAAAGCCTTCCTCGCCGAC
GGCCGCGCCGCCCTGGAACGGCTGGAACGGGCCGTCACCAACGCCCGCCGCACCGCCAGCGGCGAGGTGGGCCTGCTGCG
CATCGGCTACATGGACTTCGCCATCAACGGCCGGCTGCCGGAATTCCTGAGCGCCTTCAGTCGCTACCGGCCGGAGATTC
GGCTGGAGATCTCGTTCATCCCCACCTTCAAGCAGCAGGAGGCGCTGCTGGCGGAGCGCATCGACATCGGCTTCATGATC
GGCCCGTTCGAGGAGCCGAGCATGGAGAGCTACACCTTCGACGACAACCGCTACGTGGCGCTGCTGCCCATCACCCATCC
GCTCTCCAACGTGCGCACCCTGCGCCTCTCGGACCTTGCGGACCAGCCCTTCGTGCTCGGCTCGGGCGAGAACTGGGGCG
CCTTCCGCAACGCCTTCTTCTCCATCTGCCACCGCGCCGGCTTCACCCCGCGCATCACCCAGGAGGCCTCCTCGTCGGAA
GGCATTTTCGGGCTGGTCGCAGCGGGGGCCGGAGTCTCGGTCTATGCCAGCTGCGTGCGCAACCTGCAGCGGCGCGGCAT
CGTCATCCGCGATCTCGACGACGTGTCGGAAAAGATCGTCACCGTGGCCGCCTGGGCCACTCCGGTGCGCTCGCCGGCGG
TCTCCATCTTCACCGATTTCCTGCTGAGGGTGTGGGGCAGCGTCTAG

Upstream 100 bases:

>100_bases
GCCATAGTCGTTGTCCCTGCTGGTTTTCCGCCCGTCTGCGCCGGACTTGCAGGGACCAGAGTGCTCAATCTTCTATGACA
GGAGAAATTCCAAATTTCGC

Downstream 100 bases:

>100_bases
CCGCCGCTCCGCCCGGAACCAGACCGTTCGGCCGGATCCCGATCAACGGGACGTGGGATAGAGCGGCTGGAGGCCACGGG
CCTTGCGCCCGTTCCGCGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTYAICDMNVPMRFDLRHVRAFVLLSEELHFSRAAQRAHMTQPAMSRLIRDLEQDVGVPLIARTTRSVELTEAGKAFLAD
GRAALERLERAVTNARRTASGEVGLLRIGYMDFAINGRLPEFLSAFSRYRPEIRLEISFIPTFKQQEALLAERIDIGFMI
GPFEEPSMESYTFDDNRYVALLPITHPLSNVRTLRLSDLADQPFVLGSGENWGAFRNAFFSICHRAGFTPRITQEASSSE
GIFGLVAAGAGVSVYASCVRNLQRRGIVIRDLDDVSEKIVTVAAWATPVRSPAVSIFTDFLLRVWGSV

Sequences:

>Translated_308_residues
MTYAICDMNVPMRFDLRHVRAFVLLSEELHFSRAAQRAHMTQPAMSRLIRDLEQDVGVPLIARTTRSVELTEAGKAFLAD
GRAALERLERAVTNARRTASGEVGLLRIGYMDFAINGRLPEFLSAFSRYRPEIRLEISFIPTFKQQEALLAERIDIGFMI
GPFEEPSMESYTFDDNRYVALLPITHPLSNVRTLRLSDLADQPFVLGSGENWGAFRNAFFSICHRAGFTPRITQEASSSE
GIFGLVAAGAGVSVYASCVRNLQRRGIVIRDLDDVSEKIVTVAAWATPVRSPAVSIFTDFLLRVWGSV
>Mature_307_residues
TYAICDMNVPMRFDLRHVRAFVLLSEELHFSRAAQRAHMTQPAMSRLIRDLEQDVGVPLIARTTRSVELTEAGKAFLADG
RAALERLERAVTNARRTASGEVGLLRIGYMDFAINGRLPEFLSAFSRYRPEIRLEISFIPTFKQQEALLAERIDIGFMIG
PFEEPSMESYTFDDNRYVALLPITHPLSNVRTLRLSDLADQPFVLGSGENWGAFRNAFFSICHRAGFTPRITQEASSSEG
IFGLVAAGAGVSVYASCVRNLQRRGIVIRDLDDVSEKIVTVAAWATPVRSPAVSIFTDFLLRVWGSV

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=270, Percent_Identity=37.7777777777778, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788887, Length=284, Percent_Identity=31.6901408450704, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=28.4644194756554, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=29.9145299145299, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI145693105, Length=326, Percent_Identity=25.7668711656442, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790399, Length=276, Percent_Identity=26.4492753623188, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790208, Length=299, Percent_Identity=24.0802675585284, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788748, Length=248, Percent_Identity=25, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081904, Length=156, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787589, Length=149, Percent_Identity=30.8724832214765, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788296, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=193, Percent_Identity=23.8341968911917, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1789173, Length=175, Percent_Identity=30.2857142857143, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34408; Mature: 34277

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAICDMNVPMRFDLRHVRAFVLLSEELHFSRAAQRAHMTQPAMSRLIRDLEQDVGVPL
CEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCE
IARTTRSVELTEAGKAFLADGRAALERLERAVTNARRTASGEVGLLRIGYMDFAINGRLP
EEECCCCEEEHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCH
EFLSAFSRYRPEIRLEISFIPTFKQQEALLAERIDIGFMIGPFEEPSMESYTFDDNRYVA
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCCCEEE
LLPITHPLSNVRTLRLSDLADQPFVLGSGENWGAFRNAFFSICHRAGFTPRITQEASSSE
EEECCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GIFGLVAAGAGVSVYASCVRNLQRRGIVIRDLDDVSEKIVTVAAWATPVRSPAVSIFTDF
CEEEEEECCCCHHHHHHHHHHHHHCCEEEECHHHHHHHHEEHHHHHCCCCCCHHHHHHHH
LLRVWGSV
HHHHHCCC
>Mature Secondary Structure 
TYAICDMNVPMRFDLRHVRAFVLLSEELHFSRAAQRAHMTQPAMSRLIRDLEQDVGVPL
EEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCE
IARTTRSVELTEAGKAFLADGRAALERLERAVTNARRTASGEVGLLRIGYMDFAINGRLP
EEECCCCEEEHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCH
EFLSAFSRYRPEIRLEISFIPTFKQQEALLAERIDIGFMIGPFEEPSMESYTFDDNRYVA
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCCCEEE
LLPITHPLSNVRTLRLSDLADQPFVLGSGENWGAFRNAFFSICHRAGFTPRITQEASSSE
EEECCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GIFGLVAAGAGVSVYASCVRNLQRRGIVIRDLDDVSEKIVTVAAWATPVRSPAVSIFTDF
CEEEEEECCCCHHHHHHHHHHHHHCCEEEECHHHHHHHHEEHHHHHCCCCCCHHHHHHHH
LLRVWGSV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]