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The map label for this gene is garD [H]

Identifier: 154244137

GI number: 154244137

Start: 175294

End: 176817

Strand: Direct

Name: garD [H]

Synonym: Xaut_0179

Alternate gene names: 154244137

Gene position: 175294-176817 (Clockwise)

Preceding gene: 154244136

Following gene: 154244138

Centisome position: 3.3

GC content: 68.18

Gene sequence:

>1524_bases
ATGGCCGACCCGCGCACTCTGCGTCTCAACGCGGCGGACAATGTCCTCATCGCCATCGATACCGTCCCGCAGGGTGCGGC
GCTGCCCGGAGGCCTCACCGCCACGCGCACCGTGCCGCGTGGCCACAAGATCGCCTGCGCGCCCATCCCCGCGGGGGCGC
CGGTGCGCAAGTTCGGCCAGGTGATCGCCTTCGCCGGCGTGGACATCGCGCCCGGCGACTGGGTGCACGAGCACAATGTG
ATGCTCAAGGATTTCGAGCGCGACTATGCCTTCGCCTCCGAGGCGCGGCCGCTCGAAACCCTGTTGCCCGGCGAGACGCC
CGCCACCTTCGAGGGCTTCCGCCGGCCCGACGGGCGGGCCGGCACGCGCAACTATATCGGCATCCTCAGCTCGGTGAACT
GCTCGGCGACGGTGGCGGATTTCGTCGCCGACGAGGTGGCGCGCTCCGGCATCCTTGCGGACTATCCCAACATCGACGGG
GTGGTGCCCTTCACCCACGGCACCGGCTGCGGCATGGGCTCGAAGGGCGAGGAATTCGACATCCTCGCCCGCACCCAATG
GGGCTATGCCAGCCATCCCAATTTCGCCGCCGTGCTCGTCATCGGCCTCGGCTGCGAGGTGTTCCAGATCCCGCGCCTCA
AGGAGGCCTACGGCATCACAGAGGGCGACCATTTCCAGAGCCTCGTGATCCAGGAGGCCGGCGGCACCCGCAAGTCGGTG
GCGCGGGGCGTGGACAAGATCAAGGACATGCTCGCCTTCGCCAACGCGTCGCGGCGCGAGACGGTGGCGGCGTCCGAGCT
ATCCCTCGCGCTTCAGTGCGGCGGGTCGGACGGTTATTCCGGCCTCACCGCCAACCCGGCGCTGGGGGCGGCGGTGGACA
TGCTGGTGCGCCAGGGCGGCACCGCCATCCTCTCCGAAACCCCTGAAATCTATGGCGCCGAGCACCTCTTGACCCGCCGT
GCCGAAAGCGAGGAAGTGGGCCGCAAGATCGTCGATCTCATCGACTGGTGGCGGGCCTATGCGGCGCAGGCCGGCGGCGA
GCTGAACAACAATCCCTCCCCCGGCAACAAGGCGGGCGGCCTTACCACCATCCTTGAGAAGTCGCTGGGCGCGGTGGCCA
AGGGCGGCACCTCCACCCTGCGCGGCGTCTATCGCTATGCCGAGCGCATCGACCGCAAGGGCTTCGTCTATATGGACACG
CCCGGCTACGATCCGGTGGCGGCCACGGGGCAGGTGGCGGGCGGGGCCAATGTCTTGTGCTTCACCACCGGGCGCGGCTC
GGCCTACGGCTGCAAGCCCACGCCCTCCATCAAGCTGGCCACCAACACCGACCTCTATCGCCGGATGGAGGACGACATGG
ACATCAATTGCGGCGACGTGCTCGACGGCGTCAGCATCGAGGAGAAGGGCCGGGAGATCTTTTCCACCATCCTCGACGTG
GCCTCGGGCACCAAGTCCAAGTCGGAGCTTCTGGGCTACGGCCGCAACGAGTTCGTGCCCTGGCAGATCGGCGCCGTCAT
GTGA

Upstream 100 bases:

>100_bases
CACCCATCGCGGCGCCCTCGGCGATGCGCCCGGGCTGTTCCAGGACTGGCTGAAGCCCGAGGCCGGCGTCATCAAGGCGA
TTCTGGAGGTCTGACGCATC

Downstream 100 bases:

>100_bases
GGCGGGACGGGCCGGCGCCCCTCTGGTGGGGCCCCCACCCGCGGTCTTTCAAGGCCAGGTTGGCGCTTCCCTTGGTCTTC
TCGTCGTGGTGTTCTCATCC

Product: galactarate dehydratase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MADPRTLRLNAADNVLIAIDTVPQGAALPGGLTATRTVPRGHKIACAPIPAGAPVRKFGQVIAFAGVDIAPGDWVHEHNV
MLKDFERDYAFASEARPLETLLPGETPATFEGFRRPDGRAGTRNYIGILSSVNCSATVADFVADEVARSGILADYPNIDG
VVPFTHGTGCGMGSKGEEFDILARTQWGYASHPNFAAVLVIGLGCEVFQIPRLKEAYGITEGDHFQSLVIQEAGGTRKSV
ARGVDKIKDMLAFANASRRETVAASELSLALQCGGSDGYSGLTANPALGAAVDMLVRQGGTAILSETPEIYGAEHLLTRR
AESEEVGRKIVDLIDWWRAYAAQAGGELNNNPSPGNKAGGLTTILEKSLGAVAKGGTSTLRGVYRYAERIDRKGFVYMDT
PGYDPVAATGQVAGGANVLCFTTGRGSAYGCKPTPSIKLATNTDLYRRMEDDMDINCGDVLDGVSIEEKGREIFSTILDV
ASGTKSKSELLGYGRNEFVPWQIGAVM

Sequences:

>Translated_507_residues
MADPRTLRLNAADNVLIAIDTVPQGAALPGGLTATRTVPRGHKIACAPIPAGAPVRKFGQVIAFAGVDIAPGDWVHEHNV
MLKDFERDYAFASEARPLETLLPGETPATFEGFRRPDGRAGTRNYIGILSSVNCSATVADFVADEVARSGILADYPNIDG
VVPFTHGTGCGMGSKGEEFDILARTQWGYASHPNFAAVLVIGLGCEVFQIPRLKEAYGITEGDHFQSLVIQEAGGTRKSV
ARGVDKIKDMLAFANASRRETVAASELSLALQCGGSDGYSGLTANPALGAAVDMLVRQGGTAILSETPEIYGAEHLLTRR
AESEEVGRKIVDLIDWWRAYAAQAGGELNNNPSPGNKAGGLTTILEKSLGAVAKGGTSTLRGVYRYAERIDRKGFVYMDT
PGYDPVAATGQVAGGANVLCFTTGRGSAYGCKPTPSIKLATNTDLYRRMEDDMDINCGDVLDGVSIEEKGREIFSTILDV
ASGTKSKSELLGYGRNEFVPWQIGAVM
>Mature_506_residues
ADPRTLRLNAADNVLIAIDTVPQGAALPGGLTATRTVPRGHKIACAPIPAGAPVRKFGQVIAFAGVDIAPGDWVHEHNVM
LKDFERDYAFASEARPLETLLPGETPATFEGFRRPDGRAGTRNYIGILSSVNCSATVADFVADEVARSGILADYPNIDGV
VPFTHGTGCGMGSKGEEFDILARTQWGYASHPNFAAVLVIGLGCEVFQIPRLKEAYGITEGDHFQSLVIQEAGGTRKSVA
RGVDKIKDMLAFANASRRETVAASELSLALQCGGSDGYSGLTANPALGAAVDMLVRQGGTAILSETPEIYGAEHLLTRRA
ESEEVGRKIVDLIDWWRAYAAQAGGELNNNPSPGNKAGGLTTILEKSLGAVAKGGTSTLRGVYRYAERIDRKGFVYMDTP
GYDPVAATGQVAGGANVLCFTTGRGSAYGCKPTPSIKLATNTDLYRRMEDDMDINCGDVLDGVSIEEKGREIFSTILDVA
SGTKSKSELLGYGRNEFVPWQIGAVM

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=498, Percent_Identity=40.3614457831325, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1789475, Length=499, Percent_Identity=33.6673346693387, Blast_Score=268, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 53769; Mature: 53638

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPRTLRLNAADNVLIAIDTVPQGAALPGGLTATRTVPRGHKIACAPIPAGAPVRKFGQ
CCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
VIAFAGVDIAPGDWVHEHNVMLKDFERDYAFASEARPLETLLPGETPATFEGFRRPDGRA
EEHCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHCCCCCCCCC
GTRNYIGILSSVNCSATVADFVADEVARSGILADYPNIDGVVPFTHGTGCGMGSKGEEFD
CCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCCEE
ILARTQWGYASHPNFAAVLVIGLGCEVFQIPRLKEAYGITEGDHFQSLVIQEAGGTRKSV
EEEEECCCCCCCCCCEEEEEEECCCCEEECCCHHHHHCCCCCCHHHHHHEECCCCCHHHH
ARGVDKIKDMLAFANASRRETVAASELSLALQCGGSDGYSGLTANPALGAAVDMLVRQGG
HHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCC
TAILSETPEIYGAEHLLTRRAESEEVGRKIVDLIDWWRAYAAQAGGELNNNPSPGNKAGG
CEEECCCCHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LTTILEKSLGAVAKGGTSTLRGVYRYAERIDRKGFVYMDTPGYDPVAATGQVAGGANVLC
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEE
FTTGRGSAYGCKPTPSIKLATNTDLYRRMEDDMDINCGDVLDGVSIEEKGREIFSTILDV
EECCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
ASGTKSKSELLGYGRNEFVPWQIGAVM
HCCCCCHHHHHCCCCCCCCCEECCCCC
>Mature Secondary Structure 
ADPRTLRLNAADNVLIAIDTVPQGAALPGGLTATRTVPRGHKIACAPIPAGAPVRKFGQ
CCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
VIAFAGVDIAPGDWVHEHNVMLKDFERDYAFASEARPLETLLPGETPATFEGFRRPDGRA
EEHCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHCCCCCCCCC
GTRNYIGILSSVNCSATVADFVADEVARSGILADYPNIDGVVPFTHGTGCGMGSKGEEFD
CCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCCEE
ILARTQWGYASHPNFAAVLVIGLGCEVFQIPRLKEAYGITEGDHFQSLVIQEAGGTRKSV
EEEEECCCCCCCCCCEEEEEEECCCCEEECCCHHHHHCCCCCCHHHHHHEECCCCCHHHH
ARGVDKIKDMLAFANASRRETVAASELSLALQCGGSDGYSGLTANPALGAAVDMLVRQGG
HHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCC
TAILSETPEIYGAEHLLTRRAESEEVGRKIVDLIDWWRAYAAQAGGELNNNPSPGNKAGG
CEEECCCCHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LTTILEKSLGAVAKGGTSTLRGVYRYAERIDRKGFVYMDTPGYDPVAATGQVAGGANVLC
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEE
FTTGRGSAYGCKPTPSIKLATNTDLYRRMEDDMDINCGDVLDGVSIEEKGREIFSTILDV
EECCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
ASGTKSKSELLGYGRNEFVPWQIGAVM
HCCCCCHHHHHCCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 2407727; 9772162; 10762278 [H]