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The map label for this gene is uxaB [H]

Identifier: 154244131

GI number: 154244131

Start: 170122

End: 171273

Strand: Direct

Name: uxaB [H]

Synonym: Xaut_0173

Alternate gene names: 154244131

Gene position: 170122-171273 (Clockwise)

Preceding gene: 154244129

Following gene: 154244132

Centisome position: 3.2

GC content: 70.57

Gene sequence:

>1152_bases
GTGAGCGGACGCATCATCCAGTTCGGCACCAGCCGGTTTCTCCAGGCCCATGTGGACCTGTTCGTCCATGAGGCGCGACA
GGCCGGTCAGGCGGTCGGCCCCATCTGCATCGTGCAGGCTTCCGGCGCGGCGGACCGGGCCGGCCGCGTCGCCGCCTTCG
GTCGGCCCGGCGGCTATCCGGTGATCATCCGCGGCATCGAGAAGGGCGAGCGCATCGAGCGCCGCATCGATGTCACCAGC
GTCGACCGCGGCCTTTCCGCCGCGCAGGACTGGCAGGCCCTGTCCGACCTGTTCGCGAAAGATGCGGACATCATCGTCTC
CAACACCGCCGATGCGGGCTACGAGATCGCCGCCGCCGATCGCGGCCCGGCGCTGCTGGCCGGCGGTGTGCCCGTGTCGT
TTCCCGGCAAGCTCACGGCGCTGCTCCATCGCCGCTGGCGCCAGTCCGGGCGCGGGCTCACCGTGCTGCCGTGCGAACTC
ATCAACCGCAACGGCCGGGTGCTCAGTGCCGCCGTCGCCGCCCTCGCCCCCGAGGCGGGGGCGCCGGAGGCTTTCCTCGC
GTGGCTTGAGGCCGAGGTGATCTTCGCCGACACGCTGGTGGACCGCATCGTCTCGCAGGCGCTCGAGCCCATCGGCGCCG
TGGCCGAGCCCTACGCCCTTTGGGTGATCGAGCGCCGGCCGGGACTTGATCTGCCCTTCACCCATCCGAGCGTGGTGCTG
GCGGACGACCTGGAGCCGTTCGAGCGGCTGAAGCTGCATATCCTCAACCTGGGCCACACGGTGCTTGCCGACATCTGGCG
CTCCGAGCGGCGGGATCCGGGCGAGACGGTGCGGGAGATCCTCGCCGATGCCGACGTGCGCGGCCGTCTCGACGACGTGT
ACCGCCATGAAGTGCTGCCGGGATTTGCCGCCCACGGCATGGGCGAGGAGGCGCAGCGCTATGTGGCCACCACGCTGGAG
CGCTTCCTCAACCCGTTCCTCGACCACCGCATCGCCGACATCGCCCAGAACCACGCCACCAAGGTGGACCGGCGCATCAC
CGCCTTCCTGTCCTGGTGGGCGGAGGCTGGGGCCGTGGGTGCCACCCCGACCCTCGACGTGGTGATCGCACGGCGGCAGT
TCCAGCCTCAGACCGAGCGGAGCGAGGCATGA

Upstream 100 bases:

>100_bases
AAGAGAAAAACGAGGGAGGAAGGCAGATGAGCCATGGTCGGCTGCCATGGCCGCGTGCTCTGCCGGAGCTTCCTCGCGCT
GGATCTAAAAGGATTTACGC

Downstream 100 bases:

>100_bases
CCTACCAGTTCGATTTCGCGGCGCTCCTGCCCTACTGGCGCGAGTTCGCCATGGGGGTGTGGCTGACGCTGCAATTGTCC
TTCGTCGCCACGGTGCTGGG

Product: mannitol dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSGRIIQFGTSRFLQAHVDLFVHEARQAGQAVGPICIVQASGAADRAGRVAAFGRPGGYPVIIRGIEKGERIERRIDVTS
VDRGLSAAQDWQALSDLFAKDADIIVSNTADAGYEIAAADRGPALLAGGVPVSFPGKLTALLHRRWRQSGRGLTVLPCEL
INRNGRVLSAAVAALAPEAGAPEAFLAWLEAEVIFADTLVDRIVSQALEPIGAVAEPYALWVIERRPGLDLPFTHPSVVL
ADDLEPFERLKLHILNLGHTVLADIWRSERRDPGETVREILADADVRGRLDDVYRHEVLPGFAAHGMGEEAQRYVATTLE
RFLNPFLDHRIADIAQNHATKVDRRITAFLSWWAEAGAVGATPTLDVVIARRQFQPQTERSEA

Sequences:

>Translated_383_residues
MSGRIIQFGTSRFLQAHVDLFVHEARQAGQAVGPICIVQASGAADRAGRVAAFGRPGGYPVIIRGIEKGERIERRIDVTS
VDRGLSAAQDWQALSDLFAKDADIIVSNTADAGYEIAAADRGPALLAGGVPVSFPGKLTALLHRRWRQSGRGLTVLPCEL
INRNGRVLSAAVAALAPEAGAPEAFLAWLEAEVIFADTLVDRIVSQALEPIGAVAEPYALWVIERRPGLDLPFTHPSVVL
ADDLEPFERLKLHILNLGHTVLADIWRSERRDPGETVREILADADVRGRLDDVYRHEVLPGFAAHGMGEEAQRYVATTLE
RFLNPFLDHRIADIAQNHATKVDRRITAFLSWWAEAGAVGATPTLDVVIARRQFQPQTERSEA
>Mature_382_residues
SGRIIQFGTSRFLQAHVDLFVHEARQAGQAVGPICIVQASGAADRAGRVAAFGRPGGYPVIIRGIEKGERIERRIDVTSV
DRGLSAAQDWQALSDLFAKDADIIVSNTADAGYEIAAADRGPALLAGGVPVSFPGKLTALLHRRWRQSGRGLTVLPCELI
NRNGRVLSAAVAALAPEAGAPEAFLAWLEAEVIFADTLVDRIVSQALEPIGAVAEPYALWVIERRPGLDLPFTHPSVVLA
DDLEPFERLKLHILNLGHTVLADIWRSERRDPGETVREILADADVRGRLDDVYRHEVLPGFAAHGMGEEAQRYVATTLER
FLNPFLDHRIADIAQNHATKVDRRITAFLSWWAEAGAVGATPTLDVVIARRQFQPQTERSEA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=370, Percent_Identity=30.2702702702703, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790779, Length=376, Percent_Identity=27.1276595744681, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788497, Length=378, Percent_Identity=27.2486772486773, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787823, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790028, Length=237, Percent_Identity=24.4725738396624, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324401, Length=373, Percent_Identity=23.8605898123324, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=373, Percent_Identity=23.8605898123324, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 41780; Mature: 41649

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRIIQFGTSRFLQAHVDLFVHEARQAGQAVGPICIVQASGAADRAGRVAAFGRPGGYP
CCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCE
VIIRGIEKGERIERRIDVTSVDRGLSAAQDWQALSDLFAKDADIIVSNTADAGYEIAAAD
EEEECCCCCHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECC
RGPALLAGGVPVSFPGKLTALLHRRWRQSGRGLTVLPCELINRNGRVLSAAVAALAPEAG
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHCCCCC
APEAFLAWLEAEVIFADTLVDRIVSQALEPIGAVAEPYALWVIERRPGLDLPFTHPSVVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEE
ADDLEPFERLKLHILNLGHTVLADIWRSERRDPGETVREILADADVRGRLDDVYRHEVLP
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCC
GFAAHGMGEEAQRYVATTLERFLNPFLDHRIADIAQNHATKVDRRITAFLSWWAEAGAVG
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATPTLDVVIARRQFQPQTERSEA
CCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SGRIIQFGTSRFLQAHVDLFVHEARQAGQAVGPICIVQASGAADRAGRVAAFGRPGGYP
CCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCE
VIIRGIEKGERIERRIDVTSVDRGLSAAQDWQALSDLFAKDADIIVSNTADAGYEIAAAD
EEEECCCCCHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECC
RGPALLAGGVPVSFPGKLTALLHRRWRQSGRGLTVLPCELINRNGRVLSAAVAALAPEAG
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHCCCCC
APEAFLAWLEAEVIFADTLVDRIVSQALEPIGAVAEPYALWVIERRPGLDLPFTHPSVVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEE
ADDLEPFERLKLHILNLGHTVLADIWRSERRDPGETVREILADADVRGRLDDVYRHEVLP
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCC
GFAAHGMGEEAQRYVATTLERFLNPFLDHRIADIAQNHATKVDRRITAFLSWWAEAGAVG
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATPTLDVVIARRQFQPQTERSEA
CCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]