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The map label for this gene is mscL [H]

Identifier: 154244013

GI number: 154244013

Start: 58831

End: 59253

Strand: Direct

Name: mscL [H]

Synonym: Xaut_0055

Alternate gene names: 154244013

Gene position: 58831-59253 (Clockwise)

Preceding gene: 154244007

Following gene: 154244017

Centisome position: 1.11

GC content: 62.41

Gene sequence:

>423_bases
ATGCCGGTGTTGAAGGAGTTCAGGGAATTCGCGGTCAAGGGCAATGTGATGGATCTCGCCATCGGCGTGATCATCGGCGC
AGCCTTCGGCAACATCGTGACCTCGCTCGTGGGCGACATCTTCATGCCGGTCATCGGCGCCATCACCGGCGGTCTCGATT
TCTCGAACCACTTCATCCCCCTGTCGTCGGCTGTGACGGCCGACAACCTGGTGGACGCCAAAAAGCAGGGAGCGGTACTG
GCGTATGGCTCCTTCATTACCATCGCCATTAATTTCCTGATCGTGGCGGCGGTGCTGTTCCTGGTGGTGCGGACCATCAA
CACCCTGCGCCGGGCCGAGGAGAACAAGCCGGCGCCGGCGCCGACCCGCTCCGAGGTGCTGCTCACCGAGATCCGCGACA
TGCTCGCCAAACGCCCGAGCTGA

Upstream 100 bases:

>100_bases
GTTGCTCGCCTGTCGCTTGCAGTGCGCCTTGGCCCAGCGTTAAGGACGTTTCGTAAGGATTTTGGTCAAGGGTGCCATCT
CGACGGCTCGGGAGACGGAC

Downstream 100 bases:

>100_bases
CACGCCCGACCTTAGGCGCCTCAGCGCACGTCCACGCCCACCGCATCGGCAATGGAGGCGAAGCCGTCCGCCTTCAGGCG
GGCGGCGAGATCCGTCTTGA

Product: large conductance mechanosensitive channel protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MPVLKEFREFAVKGNVMDLAIGVIIGAAFGNIVTSLVGDIFMPVIGAITGGLDFSNHFIPLSSAVTADNLVDAKKQGAVL
AYGSFITIAINFLIVAAVLFLVVRTINTLRRAEENKPAPAPTRSEVLLTEIRDMLAKRPS

Sequences:

>Translated_140_residues
MPVLKEFREFAVKGNVMDLAIGVIIGAAFGNIVTSLVGDIFMPVIGAITGGLDFSNHFIPLSSAVTADNLVDAKKQGAVL
AYGSFITIAINFLIVAAVLFLVVRTINTLRRAEENKPAPAPTRSEVLLTEIRDMLAKRPS
>Mature_139_residues
PVLKEFREFAVKGNVMDLAIGVIIGAAFGNIVTSLVGDIFMPVIGAITGGLDFSNHFIPLSSAVTADNLVDAKKQGAVLA
YGSFITIAINFLIVAAVLFLVVRTINTLRRAEENKPAPAPTRSEVLLTEIRDMLAKRPS

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=139, Percent_Identity=51.0791366906475, Blast_Score=133, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 14955; Mature: 14824

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLKEFREFAVKGNVMDLAIGVIIGAAFGNIVTSLVGDIFMPVIGAITGGLDFSNHFIP
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LSSAVTADNLVDAKKQGAVLAYGSFITIAINFLIVAAVLFLVVRTINTLRRAEENKPAPA
CHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PTRSEVLLTEIRDMLAKRPS
CCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PVLKEFREFAVKGNVMDLAIGVIIGAAFGNIVTSLVGDIFMPVIGAITGGLDFSNHFIP
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LSSAVTADNLVDAKKQGAVLAYGSFITIAINFLIVAAVLFLVVRTINTLRRAEENKPAPA
CHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PTRSEVLLTEIRDMLAKRPS
CCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA