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The map label for this gene is hpt [H]

Identifier: 154243981

GI number: 154243981

Start: 23612

End: 24148

Strand: Direct

Name: hpt [H]

Synonym: Xaut_0023

Alternate gene names: 154243981

Gene position: 23612-24148 (Clockwise)

Preceding gene: 154243975

Following gene: 154243987

Centisome position: 0.44

GC content: 67.97

Gene sequence:

>537_bases
ATGACCCTGCCCAACGTCACCGTTCTCTACGACGAGAACCGCATCGCCGCCCGCAACCACTCCCTCGCGGTCGAGATCGC
CGCCACCAATCCGGAGCGCCTGCTCGCCGTCGCGGTGCTGAAGGGCTCCTTCATGTTCGCCGCCGACCTGCTGCGCGCGC
TGCACGGCTCCGGCCTTGAGCCCGAGGTGGAGTTCATGCACGTGTCCTCCTATCGCGAGGCCACGGTTTCCTCCGGCCAG
GTGGAGATCCTGCGCGACGTGCAGAGCGACGTGCGCGACCGCGACGTGCTGCTCATCGACGACATCCTCGAATCGGGCCG
CACCCTGGCCTTCGCCAAGGACCTCCTGATGGCGCGCGGGGCGCGGCGGGTACTGGTGTGCGTGCTGCTGGAGAAGCCCG
GCAAGCGGGCGGTGCACATCGACCCCGACTTCGTGGGCTTCACCTGCCCCGACGTGTTCGTAGTCGGCTACGGCATGGAC
GTGGCCCACGCCTTCCGCCAGTTGCCCTTCATCGGGCACATCAAGGGGCTGGGCTAA

Upstream 100 bases:

>100_bases
GCATACATCCGCGACGGCCCTCCCCGGGGTGCCCGGCCATCGTCCGGGTGGACGCCCCGTCCCATAAGGCCCATGCTCGC
GCATCTTGCGATGAGGAACC

Downstream 100 bases:

>100_bases
AGCCCGCGCGGCGCTTGAGCGGGGGCCAGTTTTCAGCCCGCGCGGCGCTTGAGCGAAGGGACCGCCTCACCCGCCCTTCA
TGCGCGCGGCGATGCGCTGG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTLPNVTVLYDENRIAARNHSLAVEIAATNPERLLAVAVLKGSFMFAADLLRALHGSGLEPEVEFMHVSSYREATVSSGQ
VEILRDVQSDVRDRDVLLIDDILESGRTLAFAKDLLMARGARRVLVCVLLEKPGKRAVHIDPDFVGFTCPDVFVVGYGMD
VAHAFRQLPFIGHIKGLG

Sequences:

>Translated_178_residues
MTLPNVTVLYDENRIAARNHSLAVEIAATNPERLLAVAVLKGSFMFAADLLRALHGSGLEPEVEFMHVSSYREATVSSGQ
VEILRDVQSDVRDRDVLLIDDILESGRTLAFAKDLLMARGARRVLVCVLLEKPGKRAVHIDPDFVGFTCPDVFVVGYGMD
VAHAFRQLPFIGHIKGLG
>Mature_177_residues
TLPNVTVLYDENRIAARNHSLAVEIAATNPERLLAVAVLKGSFMFAADLLRALHGSGLEPEVEFMHVSSYREATVSSGQV
EILRDVQSDVRDRDVLLIDDILESGRTLAFAKDLLMARGARRVLVCVLLEKPGKRAVHIDPDFVGFTCPDVFVVGYGMDV
AHAFRQLPFIGHIKGLG

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=152, Percent_Identity=34.8684210526316, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI9910262, Length=145, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=39.8843930635838, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=38.150289017341, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19541; Mature: 19410

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPNVTVLYDENRIAARNHSLAVEIAATNPERLLAVAVLKGSFMFAADLLRALHGSGLE
CCCCCEEEEECCCEEEECCCEEEEEEECCCHHHHEEEHHHHCCHHHHHHHHHHHHCCCCC
PEVEFMHVSSYREATVSSGQVEILRDVQSDVRDRDVLLIDDILESGRTLAFAKDLLMARG
CCEEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHHHHCC
ARRVLVCVLLEKPGKRAVHIDPDFVGFTCPDVFVVGYGMDVAHAFRQLPFIGHIKGLG
CCEEEEEEEECCCCCEEEEECCCCCCEECCCEEEEECCHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure 
TLPNVTVLYDENRIAARNHSLAVEIAATNPERLLAVAVLKGSFMFAADLLRALHGSGLE
CCCCEEEEECCCEEEECCCEEEEEEECCCHHHHEEEHHHHCCHHHHHHHHHHHHCCCCC
PEVEFMHVSSYREATVSSGQVEILRDVQSDVRDRDVLLIDDILESGRTLAFAKDLLMARG
CCEEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHHHHCC
ARRVLVCVLLEKPGKRAVHIDPDFVGFTCPDVFVVGYGMDVAHAFRQLPFIGHIKGLG
CCEEEEEEEECCCCCEEEEECCCCCCEECCCEEEEECCHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]