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The map label for this gene is hexR [H]

Identifier: 153950876

GI number: 153950876

Start: 2328803

End: 2329672

Strand: Direct

Name: hexR [H]

Synonym: YpsIP31758_2023

Alternate gene names: 153950876

Gene position: 2328803-2329672 (Clockwise)

Preceding gene: 153947150

Following gene: 153950254

Centisome position: 49.3

GC content: 46.9

Gene sequence:

>870_bases
ATGAATACGCTGGAAAATATCCAAAATAGTATGGACCTTCTGAGCAAATCAGAAAGGAAAGTCGCCGAGGTAATCCTTGC
CTCCCCGCAAACGGCCATCCATTCTAGTATCGCTACACTTGCCAAAATGGCGAATGTCAGCGAACCGACAGTCAACCGTT
TTTGCCGTCGTCTGGAGACCAAAGGTTTCCCTGATTTTAAACTGCATTTGGCGCAAAGTCTGGCGAACGGTACACCCTAT
GTGAATCGTAACGTCGAAGAAGATGATAGTGTAGCTGCGTACACCGGAAAAATTTTTGAATCGACGATGGCCAGCTTGGA
CCGCGTAAAAAACAATCTGGATATCGCCGCCATTAACCGGGCTGTCGATTTATTGACTCAAGCGAAAAAAATCTCGTTCT
TTGGCCTGGGTTCCTCCGCTGCCGTTGCTCATGATGCGATGAATAAGTTTTTCCGCTTTAATATCCCAGTAATTTATTTC
GATGACATCGTTATGCAACGCATGAGTTGTATGAACTCAAGTGAAGGCGATGTGGTAGTGTTGATCTCCCACACAGGGCG
AACCAAAAGCCTGGTGGAGCTGGCGCAGTTGGCTCGTGAAAATGATGCTGCCGTGATTGCCATAACTTCATGTGATACGC
CACTGGCCAACGAAGCAACCTTATCGCTGTTGCTGGATGTGCCGGAAGATACCGATATGTATATGCCAATGGTGTCACGC
ATCGCCCAGCTCACGTTGATTGATGTGCTGGCAACGGGCTTCACCCTACGGCGAGGAGCAAAATTTAGGGATAATTTGAA
GCGGGTTAAAGAGGCATTGAAAGAATCTCGTTTTGATAAGGATTCTTTGCCAGTAAACAACGGTGATTAA

Upstream 100 bases:

>100_bases
CCACTGCCAACGGGTACCAGCTCGTAGTATATTTTCATTAAACCGGCATAGATTTCTCCTTTATATGAAATCGGTAAAAC
CCATGGGTGGCTCTCGTTAT

Downstream 100 bases:

>100_bases
CATCATGAGCGGAAGTCACGTTGCCTTGTGTTAGCGCATCTTTTGTCGTAATAACTTGACGTATTATTGAGAGATAATCG
TCGTCATGGCCCGGAGAGGG

Product: HexR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYF
DDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVPEDTDMYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD

Sequences:

>Translated_289_residues
MNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYF
DDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVPEDTDMYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD
>Mature_289_residues
MNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYF
DDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVPEDTDMYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=283, Percent_Identity=82.6855123674912, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI87082369, Length=238, Percent_Identity=25.6302521008403, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.0992366412214, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082130, Length=195, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31883; Mature: 31883

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLET
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYFDDIVMQRMSCMNSSEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVPEDTDMYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHH
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLET
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYFDDIVMQRMSCMNSSEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVPEDTDMYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHH
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]