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The map label for this gene is gor [H]

Identifier: 153950800

GI number: 153950800

Start: 4558461

End: 4559813

Strand: Direct

Name: gor [H]

Synonym: YpsIP31758_4049

Alternate gene names: 153950800

Gene position: 4558461-4559813 (Clockwise)

Preceding gene: 153947250

Following gene: 153949252

Centisome position: 96.51

GC content: 52.11

Gene sequence:

>1353_bases
ATGACCAAACATTACGATTATCTGGCAATTGGCGGTGGCAGTGGCGGGATCGCATCGATCAACCGGGCAGCCATGTACGG
TAAAAAATGCGCGTTGATCGAAGCTAAACAGCTCGGTGGCACCTGTGTTAACGTCGGTTGTGTACCAAAGAAAGTGATGT
GGCATGCGGCGCAGATTGCGGAAGCCATCCATTTGTATGGACCGGATTACGGCTTCGACACCACAGTGAACCACTTCGAT
TGGAAAAAGCTGATTGCTAACCGTACTGCTTACATCGATCGTATCCATCAGTCCTATGAGCGCGGTTTAGGCAATAATAA
AGTGGATGTTATCCAAGGCTTCGCCCGCTTTGTGGATGCCCACACCGTGGAAGTTAACGGTGAGACGATCACCGCAGATC
ACATCCTGATCGCTACCGGTGGCCGCCCAAGCCATCCCGATATCCCTGGTGCTGAATATGGTATCGACTCCGATGGTTTC
TTCGAATTAGATGAGATGCCAAAACGTGTCGCTGTCGTGGGCGCAGGTTATATCGCGGTAGAAATTGCTGGCGTACTCAA
CGGGTTAGGTACCGAGACACACTTGTTTGTCCGCAAACATGCGCCGTTGCGTACCTTTGATCCGCTAATTGTTGAAACCC
TGTTGGAAGTGATGAACACCGAAGGGCCGAAACTGCATACCGAATCGGTACCGAAAGCGGTTATCAAAAACGCCAATGGC
AGCCTGACGCTGCAATTAGAAAATGGTACTGAAGTCACTGTTGACCACCTGATCTGGGCGATTGGCCGTGAACCCGCAAC
CGACAACCTGAACCTGTCTGTCACCGGTGTTAAGACCAATGACAAAGGCTATATCGAGGTTGATAAGTTCCAGAACACCA
ACGTCAAAGGCATCTACGCCGTCGGTGATAACACTGGCGCGGTTGAACTGACCCCGGTTGCCGTTGCGGCGGGCCGCCGT
TTGTCCGAACGTCTGTTCAATAACAAGCCGGATGAGCATTTGGATTACAGCAATATCCCAACCGTGGTATTCAGCCATCC
GCCAATCGGTACTATCGGCCTGACCGAGCCACAAGCCAGAGAGAAATTTGGCGACGATCAGGTGAAAGTGTACACATCCT
CGTTCACCGCGATGTACAGTGCTGTCACTCAACACCGCCAGCCATGCCGGATGAAATTAGTCTGCGTGGGTGCCGAAGAG
AAGATTGTCGGTATTCACGGCATCGGTTTCGGAATGGACGAGATCCTGCAAGGGTTCGCGGTCGCCGTGAAGATGGGCGC
GACCAAGAAAGATTTCGACAACACTGTCGCTATCCACCCTACCGCCGCAGAAGAGTTCGTTACCATGAGATGA

Upstream 100 bases:

>100_bases
ACACTGTTAGGCAATTTTAAACGACTCTACCCTCAATAATGCGCGTTACGCGAAAGCGGCAACGTGCAGTATGACCGGGT
ATCTCATGGAAACGACCTTG

Downstream 100 bases:

>100_bases
TTTCGTTACTATGGCCCGAACAGGCAGAGACTCCTGCACGGGCCATGTTTCTGAAATAAACAAAGCTAGGTTGAACATGA
GCTAACCTGGCTTTTATCTT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD
WKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNANG
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEE
KIVGIHGIGFGMDEILQGFAVAVKMGATKKDFDNTVAIHPTAAEEFVTMR

Sequences:

>Translated_450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD
WKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNANG
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEE
KIVGIHGIGFGMDEILQGFAVAVKMGATKKDFDNTVAIHPTAAEEFVTMR
>Mature_449_residues
TKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFDW
KKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFF
ELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNANGS
LTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGAVELTPVAVAAGRRL
SERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEK
IVGIHGIGFGMDEILQGFAVAVKMGATKKDFDNTVAIHPTAAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=54.1125541125541, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.3684210526316, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=37.0614035087719, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=33.9168490153173, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=31.2910284463895, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=27.5109170305677, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=85.3333333333333, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=28.7257019438445, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=29.8056155507559, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=26.5795206971678, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56.6666666666667, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=56.6666666666667, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=35.5789473684211, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.0956340956341, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=28.2937365010799, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17559934, Length=186, Percent_Identity=30.1075268817204, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=50.752688172043, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=27.5789473684211, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.3070362473348, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=39.9150743099788, Blast_Score=291, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=39.9150743099788, Blast_Score=291, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=39.9150743099788, Blast_Score=291, Evalue=9e-79,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=38.0549682875264, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.004329004329, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585130, Length=188, Percent_Identity=26.5957446808511, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48859; Mature: 48728

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEEECCHHEE
EIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNANG
EHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCC
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAR
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEECCCCCHHH
EKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
VAVKMGATKKDFDNTVAIHPTAAEEFVTMR
EEHCCCCCCCCCCCEEEECCCCHHHHEECC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEEECCHHEE
EIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNANG
EHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCC
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAR
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEECCCCCHHH
EKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
VAVKMGATKKDFDNTVAIHPTAAEEFVTMR
EEHCCCCCCCCCCCEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]