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The map label for this gene is gabT [H]

Identifier: 153950482

GI number: 153950482

Start: 1435823

End: 1437112

Strand: Direct

Name: gabT [H]

Synonym: YpsIP31758_1218

Alternate gene names: 153950482

Gene position: 1435823-1437112 (Clockwise)

Preceding gene: 153946891

Following gene: 153949750

Centisome position: 30.4

GC content: 52.56

Gene sequence:

>1290_bases
ATGAGTCACCGTGAATTGGAACAACGTAGAAAAGAGGCGACCCCACGTGGGATTGGTGTGTTATGTGATTTCTATGCGGT
ACGGGCTGAAAATGCCACGCTGTGGGATGAACAGGGGCGGGAATATATCGATTTTACGGCGGGTATTGCGACACTCAATA
TCGGACACCGCCACCCGAAAGTGATGGCCGCGGTGCGCCAACAACTGGACCAGTTTACCCATACTGCCTATCAGGTGGTG
CCTTACGCCAGCTATGTCACATTGGCGGAAAAAATTAATTCGCTAGCACCCATTTCTAATTCAAATCAAACGGCAGCGGG
CAACAGTAAAACCGCTTTTTTCACCACTGGGGTCGAAGCGATAGAAAATGCCGTGAAAATAGCGCGTGCGGCGACTGGCC
GCCCTGGTGTGATTGCTTTCTCTGGGGCATTTCATGGCCGAACCTTATTGGCGATGGCGCTGACCGGTAGAGCGGTGCCG
TACAAAGTCGGTTTTGGTCCGTTCCCTGCCTCCATTTTTCACGCCCTCTATCCCAATGAGTTGTATGGCGTGAGTGTCGA
AGAGGCCATCAGTAGTGTTGAGCGCCTGTTTCGTTGTGATATCAGTCCGACACAAGTGGCGGCCATTCTATTTGAGCCGA
TTCAGGGCGAGGGTGGTTTTAATATCGCCCCGCCGGAATTTGTCAGTGCTTTGCGCACCCTGTGTGATGAGCACGGTATT
TTGCTGATTGCCGATGAAGTACAAACGGGGTTTGCTCGTACAGGCAAGTTATTTGCCATGGAATATTATCCCGACACCAA
AGTTGATGTGATCACCATGGCGAAAAGCCTTGGGGGCGGTATGCCAATTTCCGCGGTCACGGGTCGGGCCGACATTATGG
ATGCCCCGTTGCCGGGGAGTTTGGGCGGTACCTATGCCGGTAACCCACTGGCGGTGGCTGCGTCACTGGCGGTGCTCGAT
ATTATTGCGGAAGAGAAGTTATGCGAACGCGCTCTGATTTTAGGTGCGAAGTTGGTCGAAATACTGGAAAAAGCCCAAAT
GAGCAATGCGGCCATTGTGGGCATTCGTGCGCGAGGATCTATGGTGGCGGTGGAATTTAACGATCCCGTCAGTGGTAAAC
CGTCGCCAGAACTGACGCTTGCCTATCAACGTAAGGCACTGGAAGAGGGGCTGTTACTCCTGAGTTGCGGTGTCCACAGC
AACGTGATCCGCTTCCTCTATCCATTGACCATTCCCGACAAGCAATTTAAACAGGCGATGAATATTCTTACCCGCCTACT
GGCGAGCTAA

Upstream 100 bases:

>100_bases
ATACAAATTAATCGACGAATTAGTCATTACGAACCGAGACAGTCATCCACATACGCCCCCGTGGGGGGATTGACCCATGG
CATACCAGCAGGAGCGAATC

Downstream 100 bases:

>100_bases
AGGTTTTATCTCACTGATCTCGAAACGTTAACCCGTTACCAGGAGCCACAGCATGTTTAAAATAATGACACTGACTACGC
TGCTCGCCGGATGGGTATTT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQFTHTAYQVV
PYASYVTLAEKINSLAPISNSNQTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVP
YKVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRTLCDEHGI
LLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAVAASLAVLD
IIAEEKLCERALILGAKLVEILEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTLAYQRKALEEGLLLLSCGVHS
NVIRFLYPLTIPDKQFKQAMNILTRLLAS

Sequences:

>Translated_429_residues
MSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQFTHTAYQVV
PYASYVTLAEKINSLAPISNSNQTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVP
YKVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRTLCDEHGI
LLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAVAASLAVLD
IIAEEKLCERALILGAKLVEILEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTLAYQRKALEEGLLLLSCGVHS
NVIRFLYPLTIPDKQFKQAMNILTRLLAS
>Mature_428_residues
SHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQFTHTAYQVVP
YASYVTLAEKINSLAPISNSNQTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVPY
KVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRTLCDEHGIL
LIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAVAASLAVLDI
IAEEKLCERALILGAKLVEILEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTLAYQRKALEEGLLLLSCGVHSN
VIRFLYPLTIPDKQFKQAMNILTRLLAS

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=32.2195704057279, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=32, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=30.8310991957105, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI37574042, Length=424, Percent_Identity=28.7735849056604, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=26.9953051643192, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=28.2660332541568, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=28.463476070529, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI188536080, Length=446, Percent_Identity=27.8026905829596, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=446, Percent_Identity=27.8026905829596, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=446, Percent_Identity=27.8026905829596, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787560, Length=429, Percent_Identity=65.5011655011655, Blast_Score=576, Evalue=1e-166,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=50.1176470588235, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=34.1404358353511, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=33.2512315270936, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI145693181, Length=408, Percent_Identity=33.578431372549, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=31.8051575931232, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=28.0871670702179, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=32.0388349514563, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=32.4825986078886, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=468, Percent_Identity=30.5555555555556, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=32.6460481099656, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=434, Percent_Identity=25.3456221198157, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=31.8181818181818, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=31.9711538461538, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=419, Percent_Identity=26.2529832935561, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=324, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=30.5288461538462, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=29.4642857142857, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=29.0178571428571, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21356575, Length=406, Percent_Identity=27.0935960591133, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281366494, Length=373, Percent_Identity=28.1501340482574, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667139, Length=373, Percent_Identity=28.1501340482574, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667143, Length=373, Percent_Identity=28.1501340482574, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 46145; Mature: 46014

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPK
CCHHHHHHHHHHCCCCCHHHHHHHHHEECCCCEEEHHCCCEEEEEECCEEEEECCCCCHH
VMAAVRQQLDQFTHTAYQVVPYASYVTLAEKINSLAPISNSNQTAAGNSKTAFFTTGVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHH
IENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVPYKVGFGPFPASIFHALYPNE
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCCC
LYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRTLCDEHGI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
LLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGS
EEEECCHHCCHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCC
LGGTYAGNPLAVAASLAVLDIIAEEKLCERALILGAKLVEILEKAQMSNAAIVGIRARGS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
MVAVEFNDPVSGKPSPELTLAYQRKALEEGLLLLSCGVHSNVIRFLYPLTIPDKQFKQAM
EEEEEECCCCCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHH
NILTRLLAS
HHHHHHHCC
>Mature Secondary Structure 
SHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPK
CHHHHHHHHHHCCCCCHHHHHHHHHEECCCCEEEHHCCCEEEEEECCEEEEECCCCCHH
VMAAVRQQLDQFTHTAYQVVPYASYVTLAEKINSLAPISNSNQTAAGNSKTAFFTTGVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHH
IENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVPYKVGFGPFPASIFHALYPNE
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCCC
LYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRTLCDEHGI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
LLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGS
EEEECCHHCCHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCC
LGGTYAGNPLAVAASLAVLDIIAEEKLCERALILGAKLVEILEKAQMSNAAIVGIRARGS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
MVAVEFNDPVSGKPSPELTLAYQRKALEEGLLLLSCGVHSNVIRFLYPLTIPDKQFKQAM
EEEEEECCCCCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHH
NILTRLLAS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]