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The map label for this gene is dld [H]

Identifier: 153950446

GI number: 153950446

Start: 3168430

End: 3170142

Strand: Direct

Name: dld [H]

Synonym: YpsIP31758_2805

Alternate gene names: 153950446

Gene position: 3168430-3170142 (Clockwise)

Preceding gene: 153947856

Following gene: 153946824

Centisome position: 67.08

GC content: 45.53

Gene sequence:

>1713_bases
ATGAGCCAGTTCAATAATGAAAAAATCCAGCTCTTGCTGACTCAATTACAGCATATAGTGGGTACACGCTATTTACTGAC
CGGTGAACGGCAGACTGAACGCTACCGAACCGGTTTCCGCTCCGGTAAAGGGGTGGCCCTCGCCGTGGTATTTCCGTCAA
CACTACTGCAACAATGGCAGTTACTGCAGGCTTGTGTGGCTGCTGATACCATCATTATCATGCAAGCCGCCAATACTGGG
CTGACAGAAGGCTCGACGCCAAGTGGTGATGATTATGATCGCCCTATCGTCATCTTGAATACCTTACGTCTTAACAACAT
TCAGCTATTGGATGATGGCAAACAAGTTATAGGATTCCCTGGAAGCACACTGAATCAATTAGAAAAACGCTTAAAACCTT
ATGGTCGCGAACCCCATTCGGTTATTGGCTCCTCCTGTATTGGTGCCTCGGTCGTAGGCGGTATTTGCAATAATTCAGGC
GGTTCATTGGTCCAAAGAGGCCCGGCATACACCGAAATGGCTCTGTATGCACAAATTGATGCACAAGGTGAGTTGCAGTT
AATTAATCATTTAGGCATCAGCTTGGGAAATACACCAGAAGAGATTCTACAACGTTTGGAACAAGGCCAATATGGTGCTG
AAGATATCGAACAGACCGGGCAGCAAACCTCAGATAGTGAATATGCGACGCGGGTAAGAGATATTGATGCAACGACCCCT
TCGCGTTTTAACGCCGACCCCAGACGTTTATTTGAAGCCTCCGGCTGTGCCGGTAAATTGGCAATATTTGCCGTGCGGCT
GGATACCTTCCCCAGTGAGAAACAACAACAAGTTTTTTATATCGGCACCAACCAAACCCAGGTATTGACTGAGTTACGTC
GTATTATTCTCCGCGACTTTAAACATTTACCTATCGCGGGTGAATATCTGCACCGTGATATTTTTGATATTGCGGAAACC
TATGGCAAAGATACGTTTGTGATGATTAACAGCATGGGCACCAATAACATGCCCCGATTCTTCACGTTAAAAGGTAAAAT
TGATGCTCGCCTCAATAAAATTCTGCATTTAGTCGATCACCTGACCGATCGTGTAATGCAAGGCTTTAGTCAGATATTGC
CTAACCATTTACCTAAGCGCCTTAAGACTTACCGTAATCAATATGAACATCATCTGCTGCTCAAAATGTCAGGCGATGGT
ATTACCGAAGCGCAACAACATCTACGCGCCTTTTTTGCCACTGCGGAAGGTAACTTTATTGCCTGCACGGCTGATGAAGG
TAAAAAGGCTTTTCTACACCGTTTTGCGGCGGCAGGTGCGGCAGTGCGCTATCACGCGGTCCACGCCGATCAAGTGGAAG
ATATTTTGGCACTGGATATCGCCCTGCGCCGTAATGAAAAACAGTGGTTTGAAACCTTACCACCAGAAATAGAAAAATGT
CTGATCGCGAAGCTCTATTATGGACATTTTCTGTGCCACGTCTTTCATCAAGACTATATCGTTAAGAAAGGGGTTGATGT
AAAAGCGCTAAAAGAAAAAATGTTATCGCTCCTCAATGACAAAGGTGCGGAATACCCCGCAGAACATAATGTCGGCCACC
TCTATCTGGCAAAACCCGCATTAAAAGATTTTTATCAACAGATCGACCCAACCAACAGTTTTAATCCGGGGATTGGTAAA
ACCTCAAAACGTAAGCGTTGGCAGCAAGACTGA

Upstream 100 bases:

>100_bases
AATCAACGTCGATATATTAAACGGTTAAGGGAGTAAAAGGTTGATGTAGTAAAAAGCTAATGCAGTAAAAGGCTAATGTC
ACTAACAGGGAACCACATTG

Downstream 100 bases:

>100_bases
CGCTATTAGCCAGAAATAGCACCATTAGGCTTAGGCATTATCTGAAAGCAAACAATTAGTCACTAAAGCGGAATTTGCCT
CTGCTAGCAAATTCCGCTTC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTG
LTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSG
GSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATTP
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAET
YGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKILHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDG
ITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGK
TSKRKRWQQD

Sequences:

>Translated_570_residues
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTG
LTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSG
GSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATTP
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAET
YGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKILHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDG
ITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGK
TSKRKRWQQD
>Mature_569_residues
SQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTGL
TEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGG
SLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATTPS
RFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAETY
GKDTFVMINSMGTNNMPRFFTLKGKIDARLNKILHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGI
TEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKCL
IAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGKT
SKRKRWQQD

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=569, Percent_Identity=65.0263620386643, Blast_Score=801, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64088; Mature: 63957

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQ
CCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHH
LLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFP
HHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEECC
GSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQID
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEEC
AQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATTP
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDF
CCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
KHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKILHLVDH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHH
LTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
ACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
EEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHH
LKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
SQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQ
CCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHH
LLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFP
HHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEECC
GSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQID
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEEC
AQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATTP
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDF
CCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
KHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKILHLVDH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHH
LTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
ACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
EEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHH
LKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]