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The map label for this gene is sdaC [H]

Identifier: 153950091

GI number: 153950091

Start: 3009265

End: 3010566

Strand: Direct

Name: sdaC [H]

Synonym: YpsIP31758_2656

Alternate gene names: 153950091

Gene position: 3009265-3010566 (Clockwise)

Preceding gene: 153950539

Following gene: 153949137

Centisome position: 63.71

GC content: 47.39

Gene sequence:

>1302_bases
ATGGACACTACGCAAACAAGCACTCTTGCCTCGGCAAGAAAAATCTCATCAAGTACATGGCGCAAAAGTGACACCATGTG
GATGTTGGGTCTGTACGGTACAGCGATTGGCGCAGGTGTACTCTTTTTGCCCATCAACGCCGGTATTGGTGGCCTGCTAC
CACTGATTGTTATGGCTATCATTGCTTTCCCAATGACCTACTACGCTCACCGTGGCCTGTGCCGATTCGTGTTATCCGGT
AAAAATCCAGGTGAAGATATTACTGAGGTGGTTGAAGAACATTTCGGTGTAGGCGCAGGTAAACTGATTACCCTGCTTTA
CTTCTTCGCTATCTACCCCATTCTCTTGGTGTACAGCGTAGCAATTACCAATACCGTGGATAGTTTCATTACACATCAGA
TGCACCTGCCATCACCACCACGCGCCATTTTGTCCCTGATTCTGATTGTGGGCCTGATGGCTATCGTGCGCTTTGGTGAA
CAGACCATCGTCAAAGCCATGAGCATCTTGGTATTCCCGTTTGTTGCCGTATTGATGATGTTGGCGATATACCTGATCCC
AAACTGGTCAGGTGCAATATTCGAAAACGTATCCATGGACGGTAACGGCACAGGTAGCGGCCTGTGGATGACAATGTGGC
TAATCATTCCCGTCATGGTGTTCTCTTTCAACCACTCACCGATCATCTCAGCCTTTGCTGTAGCAAAGCGCGAAGAGTAC
GGGGTGGATGCAGAGAAAAAATGTTCACGCATTTTGAGCTTTGCCCACATCATGATGGTTATCACCGTCATGTTCTTCGT
CTTCAGTTGCGTACTGAGCCTGTCTCCTGCGGATCTGATGGATGCAAAAAACCAAAACATCTCCATTTTGTCTTATCTGG
CAAACCATTTTAATACGCCAGTAATTGCCTATATGGCACCGGTTATTGCTTTTATTGCCATCACTAAATCATTCCTGGGC
CACTATCTGGGCGCCCGTGAAGGTTTTAACGGTATGGTCATTAAGTCTCTGCGTAGTAGAGGCAAAACCATTGAGCAGAA
CAAACTGAACCGCATTACTGCGTTGTTCATGTTAGTCACCACCTGGGCTGTCGCGACCTTAAACCCAAGTATCTTGGGGA
TGATCGAAACATTGGGCGGCCCTATCATCGCGATGCTCCTGTTCCTGATGCCGATGTATGCCATTCATAAAGTCCCGGCC
ATGCGTAAATACAGCGGCCAGATCAGTAACGTATTCGTGGTACTCATGGGCTTGATCGCCATCTCTGGGATCTTATTCAA
CTTAAGCAACTTGTTTAATTAG

Upstream 100 bases:

>100_bases
TGACTGAATGCTTACCTGATGATGTCATTCAATAATGCATTCCAGGTCTCTAAATTTCGGTTATTCATTTTAAATTAACG
TGTTCACAATGGAGATTTTC

Downstream 100 bases:

>100_bases
TCGATGGTTTGATTAGTAGATGGCTTGATTAACTGATCGTTTGATTAACCGCTCCAGGCTGGCCACTTCCACGGCCAGCC
TGTTATTTTTCTTCTTTTTT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGLCRFVLSG
KNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQMHLPSPPRAILSLILIVGLMAIVRFGE
QTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFAVAKREEY
GVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIAITKSFLG
HYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPA
MRKYSGQISNVFVVLMGLIAISGILFNLSNLFN

Sequences:

>Translated_433_residues
MDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGLCRFVLSG
KNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQMHLPSPPRAILSLILIVGLMAIVRFGE
QTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFAVAKREEY
GVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIAITKSFLG
HYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPA
MRKYSGQISNVFVVLMGLIAISGILFNLSNLFN
>Mature_433_residues
MDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGLCRFVLSG
KNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQMHLPSPPRAILSLILIVGLMAIVRFGE
QTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFAVAKREEY
GVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIAITKSFLG
HYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPA
MRKYSGQISNVFVVLMGLIAISGILFNLSNLFN

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=82.983682983683, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=48.9841986455982, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789211, Length=415, Percent_Identity=37.8313253012048, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI145693183, Length=436, Percent_Identity=28.2110091743119, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789961, Length=394, Percent_Identity=26.3959390862944, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 47514; Mature: 47514

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAI
CCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
IAFPMTYYAHRGLCRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AITNTVDSFITHQMHLPSPPRAILSLILIVGLMAIVRFGEQTIVKAMSILVFPFVAVLMM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFAVAKREEY
HHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCC
VIAYMAPVIAFIAITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMRKYSGQISNVFVVLMGLIA
HHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
ISGILFNLSNLFN
HHHHHHHHHHHCC
>Mature Secondary Structure
MDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAI
CCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
IAFPMTYYAHRGLCRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AITNTVDSFITHQMHLPSPPRAILSLILIVGLMAIVRFGEQTIVKAMSILVFPFVAVLMM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFAVAKREEY
HHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCC
VIAYMAPVIAFIAITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMRKYSGQISNVFVVLMGLIA
HHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
ISGILFNLSNLFN
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]