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The map label for this gene is pcp

Identifier: 153949977

GI number: 153949977

Start: 1321864

End: 1322511

Strand: Direct

Name: pcp

Synonym: YpsIP31758_1120

Alternate gene names: 153949977

Gene position: 1321864-1322511 (Clockwise)

Preceding gene: 153950669

Following gene: 153948936

Centisome position: 27.99

GC content: 50.0

Gene sequence:

>648_bases
ATGAGACGTGTATTAATTACCGGGTTCGAACCTTTTGGTGGGGAGCGGATCAATCCTTCCTGGGAAGTGGTCAAACAAAT
GAATGATTTAATGATGGGTGGCGTCAGAATTGTGGCGCGCCAGCTACCCTGCGCATTCGGTGAGGCACTGACCGCCCTGA
ACACCGCGATAGATGATGTCCAGCCCGTATTGGTACTTGCTATCGGTCAGGCGGGAGGCCGTGCGGACATTACCATTGAA
CGGGTGGCGATTAACGTTGATGACGCGCGTATCCCAGACAATTTGGGTAATCAGCCCGTTGATCAGCCTATTATTCAAGA
GGGACCTGCGGCATATTTCACCCGCCTACCGATCAAAGCCATGGTTCAGGGGATACGAGAAGCGGGGATACCGGCATCAG
TTTCTCAAACTGCGGGTACCTATGTGTGTAACCATGTTATGTATGGTTTATTGCATCGGTTAAATCAGTTTAATAATGAG
GTCAAGGGCGGTTTTATTCATATCCCTTATTTGCCAGAACAGGCAGTTGATCACCCCGGTGCGCCCAGTATGTCGGCACA
ATCAGTGTTGGTCGCGTTAGAATTGGCTATCTCTATCGCATTGCAGATTGAGCATGATTTGCATATCACGGGGGGACCAG
TTCACTGA

Upstream 100 bases:

>100_bases
CAAAAATGCGGTCATCAAAGCGCAAATCCCAACCGGGGTAGCTCTGTTGATTGTTAACGTATTTTTACTGTATTTCCTGA
TGTTTCTCTAAGGAGAGGCG

Downstream 100 bases:

>100_bases
TCTTCCAATAACCTCACGGCGGCCGAAGGTGGCGTGAGGTTACAGACAACGTCCTGGCTTAAGAGGTGGGGTTGTGATCT
GAACGGTGATTTACTCCACC

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDVQPVLVLAIGQAGGRADITIE
RVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKAMVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNE
VKGGFIHIPYLPEQAVDHPGAPSMSAQSVLVALELAISIALQIEHDLHITGGPVH

Sequences:

>Translated_215_residues
MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDVQPVLVLAIGQAGGRADITIE
RVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKAMVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNE
VKGGFIHIPYLPEQAVDHPGAPSMSAQSVLVALELAISIALQIEHDLHITGGPVH
>Mature_215_residues
MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDVQPVLVLAIGQAGGRADITIE
RVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKAMVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNE
VKGGFIHIPYLPEQAVDHPGAPSMSAQSVLVALELAISIALQIEHDLHITGGPVH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=171, Percent_Identity=25.7309941520468, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_YERP3 (A7FFS3)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400101.1
- ProteinModelPortal:   A7FFS3
- SMR:   A7FFS3
- STRING:   A7FFS3
- GeneID:   5386439
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1120
- NMPDR:   fig|349747.3.peg.1426
- eggNOG:   COG2039
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   YPSE349747:YPSIP31758_1120-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23168; Mature: 23168

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 167-167

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDV
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QPVLVLAIGQAGGRADITIERVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKA
CEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHCCHHH
MVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNEVKGGFIHIPYLPEQAVDHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCCHHHCCCCC
APSMSAQSVLVALELAISIALQIEHDLHITGGPVH
CCCCHHHHHHHHHHHHHHHEEEEECCEEECCCCCC
>Mature Secondary Structure
MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDV
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QPVLVLAIGQAGGRADITIERVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKA
CEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHCCHHH
MVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNEVKGGFIHIPYLPEQAVDHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCCHHHCCCCC
APSMSAQSVLVALELAISIALQIEHDLHITGGPVH
CCCCHHHHHHHHHHHHHHHEEEEECCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA