Click here to switch to the map view.

The map label for this gene is hasA [H]

Identifier: 153949910

GI number: 153949910

Start: 143943

End: 144560

Strand: Direct

Name: hasA [H]

Synonym: YpsIP31758_0131

Alternate gene names: 153949910

Gene position: 143943-144560 (Clockwise)

Preceding gene: 153950786

Following gene: 153947638

Centisome position: 3.05

GC content: 41.75

Gene sequence:

>618_bases
ATGAGTACAACTATTCAATATAACAGTAATTATGCCGATTACAGCATCTCCTCTTATCTTCGGGAATGGGCTAATAACTT
TGGTGATATTGATCAAGCTCCAGCTGAAACAAAAGATCGTGGGAGTTTCTCTGGTTCCTCAACCTTATTTAGCGGTACTC
AATATGCGATTGGTAGCTCGCATGGTAATCCAGAGGGAATGATTGCTGAGGGTAATTTGAAATACTCCTTTATGCCTCAG
CATACTTTCTATGGGCAAATAGACACCCTGCAGTTTGGTAAGGATTTAGCTACTAATGCGGGTGGCCCTAGTGCAGGTAA
ACATCTTGAAAAAATTGATATAACCTTTAACGAACTGGATCTTAGCGGTGAATTTGATTCTGGCAAATCAATGACAGAAA
ACCACCAAGGTGATATGCATAAAGCCATACTTGGTTTGAGGAAAGGTAACGCAGATCCAATGCTGGAAGTGATGAAGGCC
AAAGGCTTTGATGTTGATACTGCTTTTAAAGACCTGTCTATTGCCAGCCAATATCCTGACAGTGGTTATATGTCTGATGC
GCCAATGGTGGATACCGTTGGTGTGATGGATAGCAACGATATGCTGCTAGCCGCTTAA

Upstream 100 bases:

>100_bases
ACTTGAAGTATACGAGAATAATATATTTCACTTATGGAACCGCATGGATTAATAATAATCCATGTTCACCGTAACAATTA
ATAATTAAAAGGAAATTATC

Downstream 100 bases:

>100_bases
GAAAAACAGCCAGAAAATAACTTTCTGGCTGAGTCACTGATACCACCGCTAGGGCTTACTGGCCGGTTTGCTGTAGCGGT
GGTGCAGATTGTAGTTGTCC

Product: hemophore HasA

Products: NA

Alternate protein names: Heme acquisition system protein A [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHGNPEGMIAEGNLKYSFMPQ
HTFYGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKAILGLRKGNADPMLEVMKA
KGFDVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA

Sequences:

>Translated_205_residues
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHGNPEGMIAEGNLKYSFMPQ
HTFYGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKAILGLRKGNADPMLEVMKA
KGFDVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA
>Mature_204_residues
STTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHGNPEGMIAEGNLKYSFMPQH
TFYGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKAILGLRKGNADPMLEVMKAK
GFDVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA

Specific function: Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010495 [H]

Pfam domain/function: PF06438 HasA [H]

EC number: NA

Molecular weight: Translated: 22208; Mature: 22076

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSS
CCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECC
HGNPEGMIAEGNLKYSFMPQHTFYGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELD
CCCCCCEEEECCEEEEEECCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEEEEEEEEEEEE
LSGEFDSGKSMTENHQGDMHKAILGLRKGNADPMLEVMKAKGFDVDTAFKDLSIASQYPD
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SGYMSDAPMVDTVGVMDSNDMLLAA
CCCCCCCCCEEEEEEECCCCEEEEC
>Mature Secondary Structure 
STTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSS
CCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECC
HGNPEGMIAEGNLKYSFMPQHTFYGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELD
CCCCCCEEEECCEEEEEECCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEEEEEEEEEEEE
LSGEFDSGKSMTENHQGDMHKAILGLRKGNADPMLEVMKAKGFDVDTAFKDLSIASQYPD
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SGYMSDAPMVDTVGVMDSNDMLLAA
CCCCCCCCCEEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7937909; 9188703; 9171402; 10360351; 10966573 [H]