Click here to switch to the map view.

The map label for this gene is nhaA

Identifier: 153949836

GI number: 153949836

Start: 3903598

End: 3904782

Strand: Reverse

Name: nhaA

Synonym: YpsIP31758_3464

Alternate gene names: 153949836

Gene position: 3904782-3903598 (Counterclockwise)

Preceding gene: 153950863

Following gene: 153948606

Centisome position: 82.67

GC content: 47.0

Gene sequence:

>1185_bases
GTGACAAATATCATTCGTCAATTTTTACGCCAAGAGGCCGCAGGTGGCCTGATTCTGATTATTGCTGCCGCTATTGCCCT
GTTGATGGCGAACAGTGCCCTACAAGGGATTTATCAATCATTTCTTGATATACCAGTCTCGATAAAAATAGCTTCGCTGG
ATATCAGTAAACCGTTATTGCTGTGGATTAACGATGGTCTAATGGCGGTATTTTTCCTGGTGGTAGGGCTGGAAGTTAAA
CGTGAGTTGATGGAAGGCTCTCTGGCGGGCCGCGATAAAGCAGTTTTTCCCGCGATTGCTGCATTGGGGGGGATGTTAGC
CCCAGCGCTGATTTACTTACTGTTCAATGGTGCTGATGAGGTGACCCGCCAAGGGTGGGCGATCCCAGCAGCGACTGATA
TTGCGTTTGCCTTGGGAGTGATGGCGCTATTAGGTAACCGGGTACCAACCGGGCTGAAGGTCTTTTTACTGGCATTAGCC
ATTATCGATGATCTTGGTGTCATTATTATTATTGCGTTGTTCTATACCCAGCAGGTTTCATTACAATCTTTGGGTATTGC
TGCGGCTGCTATTGCTTTACTGGCGTATATGAACTGGCGTGGTGTAGGGAAAACATCAGCTTATCTGCTGGTCGGCTTGG
TTTTGTGGGTTTGTATTCTTAAATCGGGTGTACATGCGACTTTGGCTGGGGTGATTGTTGGCTTTATGATCCCGCTGCAT
ACCCAAGACCAACGCTCTCCTTCTGAATCGCTGGAGCATGGTTTACATCCGTGGGTTGCCTATTTAATTTTGCCATTGTT
TGCTTTTGCCAATGCGGGGGTCTCTTTACAAGGCGTTTCTCTTTCAGGGCTGACGTCACTGCTGCCGATGGGGATTGCAA
CAGGTCTGTTTATCGGTAAACCGTTGGGAATTTTCACTTTTAGTTGGCTCGCGGTTAAGTTAGGAATTGCTAAACTGCCC
GATGCAATAAATTTTAAGCAAATTTTTGCAGTTTCAGTGTTGTGTGGGATCGGCTTTACTATGTCGATATTTATCGCATC
ACTGGCATTTGAAGGCACAGATATCGCTCTGACGACCTATTCCAAACTAGGGATATTGCTAGGCTCTACCACAGCGGCTG
TTGTGGGTTACAGCTTACTGCGTTTGGTTTTACCCGCTCGGCGGAAGGCTGTTAACGTAAGGTAA

Upstream 100 bases:

>100_bases
CGTGATAAAAATGAATTTTTTCGATCTGATAATTATCTTAAAATTCGTGACTTGATTTGCCGAGCAACCGCTTTCTGTCC
GATGTAAGGAGTTATCCATT

Downstream 100 bases:

>100_bases
TGTACCATCACGTTATTGATTCAGCATTGCTGCCCAAGCGCAGGCAGCAATGCTTGGTGGAATTTAAAGATGGTTTGTCG
TGCATGAGGCCATGTATCTG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLVVGLEVK
RELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALA
IIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLP
DAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR

Sequences:

>Translated_394_residues
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLVVGLEVK
RELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALA
IIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLP
DAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
>Mature_393_residues
TNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLVVGLEVKR
ELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAI
IDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLHT
QDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLPD
AINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=381, Percent_Identity=66.1417322834646, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_YERP3 (A7FME1)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402419.1
- ProteinModelPortal:   A7FME1
- SMR:   A7FME1
- STRING:   A7FME1
- GeneID:   5388403
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3464
- NMPDR:   fig|349747.3.peg.3251
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   LIHWIND
- ProtClustDB:   PRK09561
- BioCyc:   YPSE349747:YPSIP31758_3464-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41687; Mature: 41555

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x231b9dd8)-; HASH(0x22e49484)-; HASH(0x22e4e0f0)-; HASH(0x231ffb4c)-; HASH(0x21dbb5d0)-; HASH(0x203a4de0)-; HASH(0x231c4c90)-; HASH(0x228feb00)-; HASH(0x231c2a34)-; HASH(0x22b2b0e4)-; HASH(0x22e48aa0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMAVFFLVVGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADE
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
VTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGK
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCC
PLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTY
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
SKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
TNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLL
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMAVFFLVVGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADE
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
VTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGK
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCC
PLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTY
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
SKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA