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The map label for this gene is uhpC [H]

Identifier: 153949496

GI number: 153949496

Start: 4597810

End: 4599141

Strand: Reverse

Name: uhpC [H]

Synonym: YpsIP31758_4078

Alternate gene names: 153949496

Gene position: 4599141-4597810 (Counterclockwise)

Preceding gene: 153948078

Following gene: 153949762

Centisome position: 97.37

GC content: 47.22

Gene sequence:

>1332_bases
ATGTGGTTTTTCCTCAAAAGTCGCGATAACGTACCGCCAGTAACGGATCAAACACAAATTGATTCATCCTATAAGTATTG
GCGTATCCAATTAATGTGGACGATGTATATCGGCTACGCTGCGTTTTATTTCACTCGTAAAAGTTTCAATTTTATTATGC
CTGCTATGCTCACGGACCTAGGGCTGAGCATGTCTGATGTCGGGATTTTAGGCACGCTGTTTTACATCACTTACGGCTGC
TCTAAATTTGTCTCTGGGATGATCAGCGATCGCTCAAATCCGCGTTATTTTATGGGGATCGGGTTGGTCATGACGGGGAT
TATTAATATCCTGTTTGGCATGAGCTCATCACTTTTGGTCCTTGGCGCCTTGTGGATCCTCAATGCGTTCTTCCAAGGTT
GGGGCTGGCCACCATGTTCTAAAATATTGACCAGTTGGTACTCGCGTTCTGAACGTGGTGGCTGGTGGGCTATTTGGAAC
ACCTCACATAACTTTGGCGGGGCGCTGATCCCCTTGCTCGTCGGGGTGATTACTCTGCACTTTAGCTGGCGCTACGGGAT
GATCATCCCCGGTATTATAGGTGTGGTGATTGGTTTGCTGATGTGTTGGCGTCTGCGAGATAAGCCAAGCACCATGGGCC
TACCAAGTGTGGGTAAATGGCGCAATGATGCGATGGAGCTGATCCAGGAATCCGAAGGCCAGGGGCTGTCTAATAAAGAA
ATTGTGAAGCGTTATGTCTTAACCAATAAATATATTTGGTTGTTAGCCGTTTCCTATGTGCTGGTTTATATCGTTCGAAC
CGCGATTAATGACTGGGGTAACCTCTATCTGACCCAAGAGAAAGGCTATTCGTTGCTGACCGCTAACTCTGCAATTTCAT
TATTTGAAGTGGGTGGATTTATTGGTTCATTGGTCGCAGGTTGGGGTTCTGATAAGTGGTTCCGTGGCAATCGTGGGCCG
ATGAACCTGATTTTTGCTATTGGTATCTTCCTCTCAGTTGCATCACTGTGGACGTTGCCAAGCATCAGTTTTGTTTTACA
GGCAGGCTGCTTCTTTGCGATTGGTTTCTTTATTTTCGGGCCACAAATGCTGATTGGTATGGCTGCTGCTGAGTGCTCTC
ATAAGGATGCCGCTGGCGCTGCAACCGGCTTTGTTGGGCTGTTTGCCTATTTAGGGGCGGCTTTATCGGGTTACCCTATC
GCTCGCATCATGGAAATCTGGCATTGGAATGGTTTCTTTGTGGTTATCTCTGTAGCGGCATGTTTATCTGCTTTCTTCTT
ATTGCCATTCCTGCGAGCGCAATCGCCGCAGTTAAAGCAAGCGACAACCTGA

Upstream 100 bases:

>100_bases
AACTAAGAAATATTCTCGTTGGTAGCGAGAATTCCCCCGTGTGTTTTCATACACATGCAGATGATGATTATTGCACTTAC
AAAATACCCTGAGGCCCGAG

Downstream 100 bases:

>100_bases
TTTGAGCGTGAAGGCGGCCATTTTCACTGCGGGTGATGATTTTAACAGCAGTCATCCGCAGGTTATTAAAAAGTGATTGA
CGCCCCAGAGCTGTAGCAGT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MWFFLKSRDNVPPVTDQTQIDSSYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLTDLGLSMSDVGILGTLFYITYGC
SKFVSGMISDRSNPRYFMGIGLVMTGIINILFGMSSSLLVLGALWILNAFFQGWGWPPCSKILTSWYSRSERGGWWAIWN
TSHNFGGALIPLLVGVITLHFSWRYGMIIPGIIGVVIGLLMCWRLRDKPSTMGLPSVGKWRNDAMELIQESEGQGLSNKE
IVKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLLTANSAISLFEVGGFIGSLVAGWGSDKWFRGNRGP
MNLIFAIGIFLSVASLWTLPSISFVLQAGCFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISVAACLSAFFLLPFLRAQSPQLKQATT

Sequences:

>Translated_443_residues
MWFFLKSRDNVPPVTDQTQIDSSYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLTDLGLSMSDVGILGTLFYITYGC
SKFVSGMISDRSNPRYFMGIGLVMTGIINILFGMSSSLLVLGALWILNAFFQGWGWPPCSKILTSWYSRSERGGWWAIWN
TSHNFGGALIPLLVGVITLHFSWRYGMIIPGIIGVVIGLLMCWRLRDKPSTMGLPSVGKWRNDAMELIQESEGQGLSNKE
IVKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLLTANSAISLFEVGGFIGSLVAGWGSDKWFRGNRGP
MNLIFAIGIFLSVASLWTLPSISFVLQAGCFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISVAACLSAFFLLPFLRAQSPQLKQATT
>Mature_443_residues
MWFFLKSRDNVPPVTDQTQIDSSYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLTDLGLSMSDVGILGTLFYITYGC
SKFVSGMISDRSNPRYFMGIGLVMTGIINILFGMSSSLLVLGALWILNAFFQGWGWPPCSKILTSWYSRSERGGWWAIWN
TSHNFGGALIPLLVGVITLHFSWRYGMIIPGIIGVVIGLLMCWRLRDKPSTMGLPSVGKWRNDAMELIQESEGQGLSNKE
IVKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLLTANSAISLFEVGGFIGSLVAGWGSDKWFRGNRGP
MNLIFAIGIFLSVASLWTLPSISFVLQAGCFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISVAACLSAFFLLPFLRAQSPQLKQATT

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=427, Percent_Identity=35.3629976580796, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI4503847, Length=427, Percent_Identity=35.3629976580796, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI256219483, Length=427, Percent_Identity=35.3629976580796, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI256219543, Length=449, Percent_Identity=34.7438752783964, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI256219564, Length=358, Percent_Identity=34.9162011173184, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI46361976, Length=393, Percent_Identity=21.6284987277354, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI14150047, Length=178, Percent_Identity=24.1573033707865, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI38093649, Length=401, Percent_Identity=24.1895261845387, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI223717983, Length=151, Percent_Identity=27.8145695364238, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87082310, Length=434, Percent_Identity=65.2073732718894, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1788573, Length=429, Percent_Identity=36.1305361305361, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI2367259, Length=419, Percent_Identity=32.6968973747017, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI2367379, Length=374, Percent_Identity=23.7967914438503, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082320, Length=339, Percent_Identity=22.4188790560472, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561094, Length=403, Percent_Identity=22.5806451612903, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17542316, Length=457, Percent_Identity=22.1006564551422, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI133930953, Length=433, Percent_Identity=24.7113163972286, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI133901854, Length=439, Percent_Identity=23.0068337129841, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133901856, Length=439, Percent_Identity=23.0068337129841, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539138, Length=291, Percent_Identity=21.6494845360825, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24656866, Length=423, Percent_Identity=22.2222222222222, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550478, Length=423, Percent_Identity=22.2222222222222, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656861, Length=423, Percent_Identity=22.2222222222222, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49451; Mature: 49451

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFFLKSRDNVPPVTDQTQIDSSYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLTDL
CEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GLSMSDVGILGTLFYITYGCSKFVSGMISDRSNPRYFMGIGLVMTGIINILFGMSSSLLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHH
LGALWILNAFFQGWGWPPCSKILTSWYSRSERGGWWAIWNTSHNFGGALIPLLVGVITLH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
FSWRYGMIIPGIIGVVIGLLMCWRLRDKPSTMGLPSVGKWRNDAMELIQESEGQGLSNKE
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH
IVKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLLTANSAISLFEVGGF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHHH
IGSLVAGWGSDKWFRGNRGPMNLIFAIGIFLSVASLWTLPSISFVLQAGCFFAIGFFIFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPIARIMEIWHWNGFFVVISVAA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
CLSAFFLLPFLRAQSPQLKQATT
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MWFFLKSRDNVPPVTDQTQIDSSYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLTDL
CEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GLSMSDVGILGTLFYITYGCSKFVSGMISDRSNPRYFMGIGLVMTGIINILFGMSSSLLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHH
LGALWILNAFFQGWGWPPCSKILTSWYSRSERGGWWAIWNTSHNFGGALIPLLVGVITLH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
FSWRYGMIIPGIIGVVIGLLMCWRLRDKPSTMGLPSVGKWRNDAMELIQESEGQGLSNKE
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH
IVKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLLTANSAISLFEVGGF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHHH
IGSLVAGWGSDKWFRGNRGPMNLIFAIGIFLSVASLWTLPSISFVLQAGCFFAIGFFIFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPIARIMEIWHWNGFFVVISVAA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
CLSAFFLLPFLRAQSPQLKQATT
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]