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The map label for this gene is tyrR [H]

Identifier: 153949439

GI number: 153949439

Start: 2070492

End: 2072069

Strand: Direct

Name: tyrR [H]

Synonym: YpsIP31758_1794

Alternate gene names: 153949439

Gene position: 2070492-2072069 (Clockwise)

Preceding gene: 153950068

Following gene: 153946953

Centisome position: 43.84

GC content: 48.54

Gene sequence:

>1578_bases
ATGCGCTTGGAAGTTTTTTGCGAAGACCGGCTCGGTCTCACCAGAGAGTTGCTTGATCTCTTGGTATTACGCAGCATTGA
TTTACGGGGGATCGAAATTGATCCTATTGGTCGCATTTACCTGAATTTTTCCAGTCTGGATTTCAGTATATTCAGTGCAC
TAATGATGGAGATTCGGCGTATTGATGGGGTAACAGATGTCCGTACTGTTTCCTTTATGCCATCAGAGCGCGAACACCGT
TCGTTGCGAGCGCTGCTGGAATCTATGCCAGAACCGGTATTCTCTATTGATTTAAAAGGGAACCTTGAGCTGTCTAACCC
CGCAGCCCGGGCGCTATTCTCCCTCAGTGAAGAAAAAATTCGCCATAAAACGGCGGGCAGCCTGCTGGGTGGCTATAATT
TTTCACGCTGGTTTGAAGGCGGCGATACGGCCCCTCATACTGAACGGGTATTGATCAATAATCAGGATTACCTGATGGAG
ATTACACCGATTAATCTCGAAGACGAAAACCAGAAAAAACAAACCGTTGGCGCGGTTGTGATGTTGAAATCAACCGCACG
CATGGGGCAGCAACTGCAAACTTTATCGGTCAATGATGATACCGAGTTTAGACAGATAGTGGCGGCCAGCACGAAGATGC
GCCAGGTTTTGGCTCAAGCCCGAAAATTAGCCATGCTTGATGCGCCGTTATTGCTGGTGGGGGATACAGGGACCGGTAAA
GATCTGCTGGCTCGTGCCTGTCACTTGCGCAGTCCTCGGGGGAAAATGCCATTTCTTGGTCTGAATTGTGCTTCACTGCC
AGATGAAGTGGTCGAGAGTGAATTATTCGGTTATGCGGCTGGCGCGTACCCAAACGCTATTGAAGGCAAAAAGGGCTTCT
TCGAACAGGCAAATGGGGGTTCGGTCCTATTGGATGAAATTGGTGAAATGTCACCTCGTATGCAAATCAAACTGTTGCGT
TTCCTTAATGACGGAACATTCCGCCGTGTAGGCGAAGAACATGAAGTGCATGTTGATGTGCGTGTCATTTGCGCCACCCA
AAAAAATCTGGTGGAGTTGGTGCAACGTGGGGAATTCCGTGAAGACTTATATTATCGGCTGAATGTCCTGACCATCACAT
TACCGCCATTGCGTGAGCGTCAGACCGATATCATGCCATTGACTGAGTTGTTTGTAGCGCGATTCTCTGATGAGCAAGGT
GTGCCGCGGCCAAAATTGTCACCAGAGTTGGCCAGTTTCCTGACTCACTACGGTTGGCCGGGTAATGTGCGTCAGCTTAA
AAATGCGATTTATCGTGCGCTCACTCAGTTGGAGGGGGCCGAATTAAGGCCACAGGATATCATCCTGCCGGAGTTTGAAA
TTGAAGCCACGTTGGGTGATGAAGTCCTTGATGGTTCACTTGATGACATCAGTAAGCGGTTCGAACGTTCTGTGCTGACT
CGCCTTTATCGTAATTATCCCAGCACCCGTAAACTGGCTAAACGGCTAGGTGTTTCGCATACTGCGATCGCCAATAAATT
ACGGGAGTATGGTTTAAGCAGTAAACGGCCCGCCAGTGATGAAAATGAAGAAGAATAA

Upstream 100 bases:

>100_bases
CTGTCAACTTTTGCTGACAGACTGCTTCATCAGTAAGAGGGGACAGGGTATTATCATCGCCAGTGATTCCGCACCTGTCA
TATATATAAGGTCAATACTG

Downstream 100 bases:

>100_bases
AGCGCAAAACGGCCAGTAATCAAACATAAAAAAGAGTAATAAAAAACGGCTGTACCCGAGTGGGGCAGCCGTTTTGAGTC
ACGATACAGCATTGACTAAA

Product: TyrR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSIFSALMMEIRRIDGVTDVRTVSFMPSEREHR
SLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLGGYNFSRWFEGGDTAPHTERVLINNQDYLME
ITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAASTKMRQVLAQARKLAMLDAPLLLVGDTGTGK
DLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGKKGFFEQANGGSVLLDEIGEMSPRMQIKLLR
FLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVLTITLPPLRERQTDIMPLTELFVARFSDEQG
VPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILPEFEIEATLGDEVLDGSLDDISKRFERSVLT
RLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE

Sequences:

>Translated_525_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSIFSALMMEIRRIDGVTDVRTVSFMPSEREHR
SLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLGGYNFSRWFEGGDTAPHTERVLINNQDYLME
ITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAASTKMRQVLAQARKLAMLDAPLLLVGDTGTGK
DLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGKKGFFEQANGGSVLLDEIGEMSPRMQIKLLR
FLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVLTITLPPLRERQTDIMPLTELFVARFSDEQG
VPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILPEFEIEATLGDEVLDGSLDDISKRFERSVLT
RLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE
>Mature_525_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSIFSALMMEIRRIDGVTDVRTVSFMPSEREHR
SLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLGGYNFSRWFEGGDTAPHTERVLINNQDYLME
ITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAASTKMRQVLAQARKLAMLDAPLLLVGDTGTGK
DLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGKKGFFEQANGGSVLLDEIGEMSPRMQIKLLR
FLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVLTITLPPLRERQTDIMPLTELFVARFSDEQG
VPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILPEFEIEATLGDEVLDGSLDDISKRFERSVLT
RLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=517, Percent_Identity=70.7930367504836, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=362, Percent_Identity=37.5690607734807, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1790299, Length=345, Percent_Identity=38.8405797101449, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=37.7483443708609, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=35.258358662614, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=37.6854599406528, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=38.801261829653, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1788905, Length=244, Percent_Identity=41.8032786885246, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=34.9112426035503, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI87081872, Length=249, Percent_Identity=39.3574297188755, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1786524, Length=275, Percent_Identity=40.3636363636364, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=36.6666666666667, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI87081858, Length=448, Percent_Identity=24.7767857142857, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59301; Mature: 59301

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSIFSALMMEIRR
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHH
IDGVTDVRTVSFMPSEREHRSLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKI
HCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHHHHHHHH
RHKTAGSLLGGYNFSRWFEGGDTAPHTERVLINNQDYLMEITPINLEDENQKKQTVGAVV
HHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHH
MLKSTARMGQQLQTLSVNDDTEFRQIVAASTKMRQVLAQARKLAMLDAPLLLVGDTGTGK
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCH
DLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGKKGFFEQANGG
HHHHHHHHCCCCCCCCCEECCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SVLLDEIGEMSPRMQIKLLRFLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFR
EEHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCCEEEEEEEEEECCHHHHHHHHHCCCHH
EDLYYRLNVLTITLPPLRERQTDIMPLTELFVARFSDEQGVPRPKLSPELASFLTHYGWP
HHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
GNVRQLKNAIYRALTQLEGAELRPQDIILPEFEIEATLGDEVLDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHHH
RLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSIFSALMMEIRR
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHH
IDGVTDVRTVSFMPSEREHRSLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKI
HCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHHHHHHHH
RHKTAGSLLGGYNFSRWFEGGDTAPHTERVLINNQDYLMEITPINLEDENQKKQTVGAVV
HHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHH
MLKSTARMGQQLQTLSVNDDTEFRQIVAASTKMRQVLAQARKLAMLDAPLLLVGDTGTGK
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCH
DLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGKKGFFEQANGG
HHHHHHHHCCCCCCCCCEECCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SVLLDEIGEMSPRMQIKLLRFLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFR
EEHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCCEEEEEEEEEECCHHHHHHHHHCCCHH
EDLYYRLNVLTITLPPLRERQTDIMPLTELFVARFSDEQGVPRPKLSPELASFLTHYGWP
HHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
GNVRQLKNAIYRALTQLEGAELRPQDIILPEFEIEATLGDEVLDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHHH
RLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]