Click here to switch to the map view.

The map label for this gene is hemN [C]

Identifier: 153949384

GI number: 153949384

Start: 4282149

End: 4283462

Strand: Direct

Name: hemN [C]

Synonym: YpsIP31758_3797

Alternate gene names: 153949384

Gene position: 4282149-4283462 (Clockwise)

Preceding gene: 153949441

Following gene: 284988614

Centisome position: 90.66

GC content: 51.14

Gene sequence:

>1314_bases
ATGAATATTGATCTGATGCCGTATTATGCCCAACCAGGGCCACTGCCATTTCCCAAACGTTGGGCTACGATGCCGTGGCG
TGACAGCCGGCCATTACCCGCAGAGTCACTCCAGGATAGCTGGCAGTCACTATTACAAAAAGCGCTTCCTCGCAATAAGC
GTTTACTTTACTTACACATTCCATTCTGTGCTACCCACTGTACTTTCTGTGGTTTCTACCAGAACCCGCTGCAATCCGGT
AGCACCGAACGCTATACCGATTACCTCTTGCGAGAGCTGAGCATGGAAGCCGATAGCCCACTGCTACAAGGGGGGCCAAT
TCATGCGGTCTACTTCGGTGGCGGTACACCAAGTGCACTTTCCGCACAACAATTACACAGTATTATCAGCCAATTACGCA
AGAGTTTACCGCTAGCTCCCGATTGTGAGATCACCGTTGAAGGGCGAATTTTTAATTTTGATGATGAGAGAATTGATGCC
TGTCTGGAAGCAGGGGCTAACCGTTTCTCTATCGGGGTTCAAACGTTTAACACCCGCATTCGTCAACGAATGGGCCGCAA
AGCTGACCGCGATCAGGCGATTCGTTTTCTGACTGATTTGGCGACCCGTGATCGGGCTGCTGTTGTTTGTGATCTAATGT
TCGGTTTACCGCATCAAACTCCCGAAATCTGGCAGGAAGATTTAGCCATCGTGCGTCAGCTCCCGCTGGATGGGGTTGAT
CTGTATGCTCTCAATTTGTTGCCGACCACACCGCTGGCTAAATCGGTAGAAAATAACCGGGTGGAACTGCCGACACTGGC
ACAACAATGCGACTTTTACTGCAGCGGGGCAGATAGCCTCGCACAGGCGGGTTGGCATCAGTTAAGCAACAGCCACTGGG
CGCGGACCACCCGTGAGCGCAATCTGTATAACCTGTTAATCAAGCAAGGGGCCGATTGCCTCGCATTGGGCAGTGGTGCA
GGGGGCTCCTTGCAAGGGCACGCTTACATGCAGCACCGTAGTCTGGATAACTACTATCGGTTAATCGATAGTGGGCAGAA
ACCGTTAATGATGATGACGCAAGCCAGCGGCGAACATCCGTGGCGGGCTAAATTACAAAGTGGTATTGAAGTTGGGCGTC
TGGACCTGAGCGAGTTAATTGCCGATCCGTACCCTCTCATGCCATTGATATCCCAGTGGTATCAAAGCAATCTACTGAAA
GATAACAGTTTCTGCCTGCGCCTAACCGACAGCGGGCGTTTTTGGGCCAGCAATATCATGCAGGCACTGCAAAATATTAT
TCCTTCACTCATCACAGCGGAAAGCCACTCATGA

Upstream 100 bases:

>100_bases
TCGCCATTTACTGATACAGGTCAAGATACTTCACATTAGCTATTGATCGAATGCTTATGATTATCATTTAATTTCGCACC
TGTGGTTTAGTGAGCTTGCT

Downstream 100 bases:

>100_bases
ATACGTCATCGTCTATAAATACATCGTCCTCTATGAATAGATCGTCCTCTATGAATAGATCGCCACTGGCTGAATTCCTT
GCCACCCAACCGGATGGCAC

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNIDLMPYYAQPGPLPFPKRWATMPWRDSRPLPAESLQDSWQSLLQKALPRNKRLLYLHIPFCATHCTFCGFYQNPLQSG
STERYTDYLLRELSMEADSPLLQGGPIHAVYFGGGTPSALSAQQLHSIISQLRKSLPLAPDCEITVEGRIFNFDDERIDA
CLEAGANRFSIGVQTFNTRIRQRMGRKADRDQAIRFLTDLATRDRAAVVCDLMFGLPHQTPEIWQEDLAIVRQLPLDGVD
LYALNLLPTTPLAKSVENNRVELPTLAQQCDFYCSGADSLAQAGWHQLSNSHWARTTRERNLYNLLIKQGADCLALGSGA
GGSLQGHAYMQHRSLDNYYRLIDSGQKPLMMMTQASGEHPWRAKLQSGIEVGRLDLSELIADPYPLMPLISQWYQSNLLK
DNSFCLRLTDSGRFWASNIMQALQNIIPSLITAESHS

Sequences:

>Translated_437_residues
MNIDLMPYYAQPGPLPFPKRWATMPWRDSRPLPAESLQDSWQSLLQKALPRNKRLLYLHIPFCATHCTFCGFYQNPLQSG
STERYTDYLLRELSMEADSPLLQGGPIHAVYFGGGTPSALSAQQLHSIISQLRKSLPLAPDCEITVEGRIFNFDDERIDA
CLEAGANRFSIGVQTFNTRIRQRMGRKADRDQAIRFLTDLATRDRAAVVCDLMFGLPHQTPEIWQEDLAIVRQLPLDGVD
LYALNLLPTTPLAKSVENNRVELPTLAQQCDFYCSGADSLAQAGWHQLSNSHWARTTRERNLYNLLIKQGADCLALGSGA
GGSLQGHAYMQHRSLDNYYRLIDSGQKPLMMMTQASGEHPWRAKLQSGIEVGRLDLSELIADPYPLMPLISQWYQSNLLK
DNSFCLRLTDSGRFWASNIMQALQNIIPSLITAESHS
>Mature_437_residues
MNIDLMPYYAQPGPLPFPKRWATMPWRDSRPLPAESLQDSWQSLLQKALPRNKRLLYLHIPFCATHCTFCGFYQNPLQSG
STERYTDYLLRELSMEADSPLLQGGPIHAVYFGGGTPSALSAQQLHSIISQLRKSLPLAPDCEITVEGRIFNFDDERIDA
CLEAGANRFSIGVQTFNTRIRQRMGRKADRDQAIRFLTDLATRDRAAVVCDLMFGLPHQTPEIWQEDLAIVRQLPLDGVD
LYALNLLPTTPLAKSVENNRVELPTLAQQCDFYCSGADSLAQAGWHQLSNSHWARTTRERNLYNLLIKQGADCLALGSGA
GGSLQGHAYMQHRSLDNYYRLIDSGQKPLMMMTQASGEHPWRAKLQSGIEVGRLDLSELIADPYPLMPLISQWYQSNLLK
DNSFCLRLTDSGRFWASNIMQALQNIIPSLITAESHS

Specific function: Anaerobic Transformation Of Coproporphyrinogen-III Into Protoporphyrinogen-IX. [C]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=310, Percent_Identity=28.3870967741935, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082341, Length=336, Percent_Identity=28.8690476190476, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789325, Length=270, Percent_Identity=30.7407407407407, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 49214; Mature: 49214

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDLMPYYAQPGPLPFPKRWATMPWRDSRPLPAESLQDSWQSLLQKALPRNKRLLYLHI
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
PFCATHCTFCGFYQNPLQSGSTERYTDYLLRELSMEADSPLLQGGPIHAVYFGGGTPSAL
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
SAQQLHSIISQLRKSLPLAPDCEITVEGRIFNFDDERIDACLEAGANRFSIGVQTFNTRI
CHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCHHHHHHHHHCCCCEEEEHHHHHHHHH
RQRMGRKADRDQAIRFLTDLATRDRAAVVCDLMFGLPHQTPEIWQEDLAIVRQLPLDGVD
HHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
LYALNLLPTTPLAKSVENNRVELPTLAQQCDFYCSGADSLAQAGWHQLSNSHWARTTRER
EEEEECCCCCHHHHHHCCCCCCCHHHHHHCCCEECCHHHHHHHHHHHHCCCHHHHHHHHH
NLYNLLIKQGADCLALGSGAGGSLQGHAYMQHRSLDNYYRLIDSGQKPLMMMTQASGEHP
HHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCC
WRAKLQSGIEVGRLDLSELIADPYPLMPLISQWYQSNLLKDNSFCLRLTDSGRFWASNIM
HHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHH
QALQNIIPSLITAESHS
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIDLMPYYAQPGPLPFPKRWATMPWRDSRPLPAESLQDSWQSLLQKALPRNKRLLYLHI
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
PFCATHCTFCGFYQNPLQSGSTERYTDYLLRELSMEADSPLLQGGPIHAVYFGGGTPSAL
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
SAQQLHSIISQLRKSLPLAPDCEITVEGRIFNFDDERIDACLEAGANRFSIGVQTFNTRI
CHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCHHHHHHHHHCCCCEEEEHHHHHHHHH
RQRMGRKADRDQAIRFLTDLATRDRAAVVCDLMFGLPHQTPEIWQEDLAIVRQLPLDGVD
HHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
LYALNLLPTTPLAKSVENNRVELPTLAQQCDFYCSGADSLAQAGWHQLSNSHWARTTRER
EEEEECCCCCHHHHHHCCCCCCCHHHHHHCCCEECCHHHHHHHHHHHHCCCHHHHHHHHH
NLYNLLIKQGADCLALGSGAGGSLQGHAYMQHRSLDNYYRLIDSGQKPLMMMTQASGEHP
HHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCC
WRAKLQSGIEVGRLDLSELIADPYPLMPLISQWYQSNLLKDNSFCLRLTDSGRFWASNIM
HHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHH
QALQNIIPSLITAESHS
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]