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The map label for this gene is manC [H]

Identifier: 153949150

GI number: 153949150

Start: 3421157

End: 3422563

Strand: Reverse

Name: manC [H]

Synonym: YpsIP31758_3039

Alternate gene names: 153949150

Gene position: 3422563-3421157 (Counterclockwise)

Preceding gene: 153950766

Following gene: 153949638

Centisome position: 72.46

GC content: 42.0

Gene sequence:

>1407_bases
ATGCTATTACCTGTAATTATGGCTGGAGGTGCTGGTAGCCGTTTGTGGCCATTATCCCGAGCTCTTTATCCTAAACAATT
TCTAGCGCTAACGTCAGATTTGACGATGCTACAAGAAACCCTATTGCGTCTGGACGGTCTTCCCCACCTTGCACCATTAG
TGATTTGTAACGAAGAACATCGCTTTATTATCGCAGAACAGTTGCGTCAGAAAAATCTGGTGCATAGCGGAATAGTCTTG
GAACCTGTTGGGCGCAATACCGCGCCAGCTATAGCATTGTCTGCCTTACGAGCAACAATGAGTGGGGATGATCCTCTATT
ATTGGTATTAGCAGCCGATCACGTGATTCAGGATAAACTTGCATTTATTCGTGCCGTCCAACGTGCTGAACCGCTTGCTG
AAGCGGGAAAATTGGTTACTTTTGGAATCGTGCCAAAGAGTCCGGAAACAGGATATGGATATATTCGCCAAGGGAAGCAA
GTCGTAGATGGCGCTTATCAGGTTGCTGCTTTTGTTGAGAAGCCAGATCTGATTACTGCAGAGCGGTATTTGGCTTCGGG
TGACTATTATTGGAATAGCGGTATGTTTGTATTTAAAGCATCTCGCTATCTACAGGAATTAGATCTACATCGTCCGGATA
TTTTGGCTGCCTGCAAGCAAGCCATTGCTGGTCAACATACTGATTTAGATTTTATTCGTCTCAATGAAGAAGCTTTCTCT
AGTTGCCCTGATGAATCTATCGACTATGCTGTGATGGAAAAAACTAGCGATGCCGTTGTAGTGCCACTGGATGCACAGTG
GAATGATGTTGGGTGCTGGTCAGCGCTTTGGGAAATTAATACTAAAGATGACCATGGTAATGTTATTCGTGGTGATGTAT
TAATAGAAGATACTAATAATAGCTACGTTTATTCTCAAAATAGGCTCATTGCAACTGTAGGCATTAATGATTTGGTTATT
GTTGAAACTAAAGATGCCATTTTAGTTGCTCATAAAGATAAAGTACAAAATGTTAAAGGGATCGTTGGACAGCTTAAGCT
TGAATCTCGATGTGAATATCTACAGCACCGGGAAGTCTATCGCCCTTGGGGTTCGCATGATGCTATTGCTGAAGGTGTTC
GCTACCATGTCCAACATGTAACGGTGAAACCAGGTCAACGTATTGCTACTCAAATTCATTATCACAGAGCGGAACATTGG
ATTGTGGTTTCTGGCATTGCCAAAGTACATTATGGAAAAGAAACTTATTTGGTTAATGAGAATGAATCCACTTATATTCC
CGTCGGCATTGCTCATTCTATTGAAAATCCAGGTCAGATCCCTCTGGAAATAATAGAGGTTCATACTGGTAATTACATTT
CAGAAGATGATGTGGAACGAATCGATGATTTAGGTGTAGGGTATTAA

Upstream 100 bases:

>100_bases
TAAGTAAAAAATATTATCGGGTTTCTATTTATTATTCGTTATCTGATGATTATATTTATTTGCATATCATCTCTATTTTA
AAAATAGGAAATAATTGCTC

Downstream 100 bases:

>100_bases
TTATGAAGATAAGTATTATTACTGCTACATATAATAGTGAGAGAACAATTTCGGATACCCTATCTTCTTTGGAGAAACAA
ACCTATCTGGATGTTGAGTA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MLLPVIMAGGAGSRLWPLSRALYPKQFLALTSDLTMLQETLLRLDGLPHLAPLVICNEEHRFIIAEQLRQKNLVHSGIVL
EPVGRNTAPAIALSALRATMSGDDPLLLVLAADHVIQDKLAFIRAVQRAEPLAEAGKLVTFGIVPKSPETGYGYIRQGKQ
VVDGAYQVAAFVEKPDLITAERYLASGDYYWNSGMFVFKASRYLQELDLHRPDILAACKQAIAGQHTDLDFIRLNEEAFS
SCPDESIDYAVMEKTSDAVVVPLDAQWNDVGCWSALWEINTKDDHGNVIRGDVLIEDTNNSYVYSQNRLIATVGINDLVI
VETKDAILVAHKDKVQNVKGIVGQLKLESRCEYLQHREVYRPWGSHDAIAEGVRYHVQHVTVKPGQRIATQIHYHRAEHW
IVVSGIAKVHYGKETYLVNENESTYIPVGIAHSIENPGQIPLEIIEVHTGNYISEDDVERIDDLGVGY

Sequences:

>Translated_468_residues
MLLPVIMAGGAGSRLWPLSRALYPKQFLALTSDLTMLQETLLRLDGLPHLAPLVICNEEHRFIIAEQLRQKNLVHSGIVL
EPVGRNTAPAIALSALRATMSGDDPLLLVLAADHVIQDKLAFIRAVQRAEPLAEAGKLVTFGIVPKSPETGYGYIRQGKQ
VVDGAYQVAAFVEKPDLITAERYLASGDYYWNSGMFVFKASRYLQELDLHRPDILAACKQAIAGQHTDLDFIRLNEEAFS
SCPDESIDYAVMEKTSDAVVVPLDAQWNDVGCWSALWEINTKDDHGNVIRGDVLIEDTNNSYVYSQNRLIATVGINDLVI
VETKDAILVAHKDKVQNVKGIVGQLKLESRCEYLQHREVYRPWGSHDAIAEGVRYHVQHVTVKPGQRIATQIHYHRAEHW
IVVSGIAKVHYGKETYLVNENESTYIPVGIAHSIENPGQIPLEIIEVHTGNYISEDDVERIDDLGVGY
>Mature_468_residues
MLLPVIMAGGAGSRLWPLSRALYPKQFLALTSDLTMLQETLLRLDGLPHLAPLVICNEEHRFIIAEQLRQKNLVHSGIVL
EPVGRNTAPAIALSALRATMSGDDPLLLVLAADHVIQDKLAFIRAVQRAEPLAEAGKLVTFGIVPKSPETGYGYIRQGKQ
VVDGAYQVAAFVEKPDLITAERYLASGDYYWNSGMFVFKASRYLQELDLHRPDILAACKQAIAGQHTDLDFIRLNEEAFS
SCPDESIDYAVMEKTSDAVVVPLDAQWNDVGCWSALWEINTKDDHGNVIRGDVLIEDTNNSYVYSQNRLIATVGINDLVI
VETKDAILVAHKDKVQNVKGIVGQLKLESRCEYLQHREVYRPWGSHDAIAEGVRYHVQHVTVKPGQRIATQIHYHRAEHW
IVVSGIAKVHYGKETYLVNENESTYIPVGIAHSIENPGQIPLEIIEVHTGNYISEDDVERIDDLGVGY

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=469, Percent_Identity=60.7675906183369, Blast_Score=574, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 52127; Mature: 52127

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPVIMAGGAGSRLWPLSRALYPKQFLALTSDLTMLQETLLRLDGLPHLAPLVICNEEH
CCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
RFIIAEQLRQKNLVHSGIVLEPVGRNTAPAIALSALRATMSGDDPLLLVLAADHVIQDKL
CEEHHHHHHHHCHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
AFIRAVQRAEPLAEAGKLVTFGIVPKSPETGYGYIRQGKQVVDGAYQVAAFVEKPDLITA
HHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEH
ERYLASGDYYWNSGMFVFKASRYLQELDLHRPDILAACKQAIAGQHTDLDFIRLNEEAFS
HHHHCCCCEEECCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECHHHHH
SCPDESIDYAVMEKTSDAVVVPLDAQWNDVGCWSALWEINTKDDHGNVIRGDVLIEDTNN
CCCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEECCC
SYVYSQNRLIATVGINDLVIVETKDAILVAHKDKVQNVKGIVGQLKLESRCEYLQHREVY
CEEEECCCEEEEECCCEEEEEEECCEEEEEECHHHHHHHHHHHHEEHHHHHHHHHHHHHH
RPWGSHDAIAEGVRYHVQHVTVKPGQRIATQIHYHRAEHWIVVSGIAKVHYGKETYLVNE
CCCCCHHHHHHHHHEEEEEEEECCCHHHHHHHHEECCCCEEEEEEEEEEEECCEEEEEEC
NESTYIPVGIAHSIENPGQIPLEIIEVHTGNYISEDDVERIDDLGVGY
CCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLPVIMAGGAGSRLWPLSRALYPKQFLALTSDLTMLQETLLRLDGLPHLAPLVICNEEH
CCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
RFIIAEQLRQKNLVHSGIVLEPVGRNTAPAIALSALRATMSGDDPLLLVLAADHVIQDKL
CEEHHHHHHHHCHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
AFIRAVQRAEPLAEAGKLVTFGIVPKSPETGYGYIRQGKQVVDGAYQVAAFVEKPDLITA
HHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEH
ERYLASGDYYWNSGMFVFKASRYLQELDLHRPDILAACKQAIAGQHTDLDFIRLNEEAFS
HHHHCCCCEEECCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECHHHHH
SCPDESIDYAVMEKTSDAVVVPLDAQWNDVGCWSALWEINTKDDHGNVIRGDVLIEDTNN
CCCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEECCC
SYVYSQNRLIATVGINDLVIVETKDAILVAHKDKVQNVKGIVGQLKLESRCEYLQHREVY
CEEEECCCEEEEECCCEEEEEEECCEEEEEECHHHHHHHHHHHHEEHHHHHHHHHHHHHH
RPWGSHDAIAEGVRYHVQHVTVKPGQRIATQIHYHRAEHWIVVSGIAKVHYGKETYLVNE
CCCCCHHHHHHHHHEEEEEEEECCCHHHHHHHHEECCCCEEEEEEEEEEEECCEEEEEEC
NESTYIPVGIAHSIENPGQIPLEIIEVHTGNYISEDDVERIDDLGVGY
CCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]