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The map label for this gene is ffh [H]

Identifier: 153949054

GI number: 153949054

Start: 3635262

End: 3636623

Strand: Reverse

Name: ffh [H]

Synonym: YpsIP31758_3230

Alternate gene names: 153949054

Gene position: 3636623-3635262 (Counterclockwise)

Preceding gene: 153950479

Following gene: 153949898

Centisome position: 76.99

GC content: 48.46

Gene sequence:

>1362_bases
ATGTTTGAGAACTTAACTGATCGATTGTCGCGCACACTGCGCAATATCAGCGGCCGTGGCCGGCTGACAGAAGAAAATAT
TAAAGAAACGCTACGTGAAGTGCGCATGGCATTACTTGAAGCTGACGTCGCTCTGCCCGTTGTTCGTGACTTTATAAACC
GAGTAAAAGAGCGGGCTGTTGGGCATGAAGTTAATAAAAGTCTGACGCCAGGCCAAGAATTCGTCAAAATAGTTAAAAAT
GAATTGATCAGCGCCATGGGCGAGGTCAATAACGAACTGAATCTGGCTGCACAACCGCCAGCAGTTGTGTTAATGGCTGG
CTTGCAAGGTGCGGGTAAGACCACCAGTGTAGCGAAACTGGGGAAATTTCTTAAAGAAAAACAGAAGAAAAAAGTGCTGG
TCGTGTCTGCTGACGTTTATCGCCCTGCGGCGATCAAACAGTTGGAAACCCTGGCTCAGGGTGTTGGCATTGATTTCTTC
CCGTCTGATGCACAGGAAAAACCGATTGATATTGTGAATCGTGCCCTGCAACAGGCAAAGCTTAAATTTTATGATGTTCT
GATTGTCGATACCGCAGGTCGCTTACACGTTGATGAAGCGATGATGGACGAAATCAAACAGGTTCATGCGGCGATTAAGC
CTGTTGAAACCTTGTTTGTCGTCGATGCGATGACCGGTCAGGATGCGGCGAATACCGCCAAAGCATTCAACGAAGCACTG
CCACTCACCGGTGTCGTGCTGACTAAAGTGGATGGCGATGCGCGCGGTGGTGCGGCTTTATCTATCCGCCATATCACCGG
TAAACCTATTAAATTCCTTGGCGTCGGTGAGAAATCTGATGCACTGGAACCGTTCCATCCAGACCGAATAGCCTCACGTA
TCTTGGGTATGGGCGATGTGCTGTCGCTGATTGAAGATATCGAAAGCAAAGTTGACCGTGCGCAAGCGGAGAAACTGGCA
ACAAAACTGAAAAAAGGCGATGGTTTCGATCTCAATGACTTCCTCGACCAGTTGAAGCAGATGCGCAACATGGGGGGGAT
GGCCAGTATGTTGAGTAAAATGCCAGGGGCAGGTCAGTTGCCAGAAAACGTAAAATCGCAAATGGATGATAAAGTCACGG
TGCGGATGGAGGCGATCATCAATTCTATGACGCTGAAAGAGCGCGCTAAACCTGAAATTATCAAAGGTTCACGTAAGCGC
CGTATCGCAACCGGTTCTGGTGTGCAGGTACAGGATGTTAACCGTTTGCTGAAACAGTTTGATGAAATGCAGCGCATGAT
GAAGAAAATGAAAAACGGCGGTTTGGCCAAAATGATGCGTGGCATGAAAGGTATGATGCCACCCGGGTTCCCAGGTCGCT
AA

Upstream 100 bases:

>100_bases
AACCGTTCTCCGACGTGAGGGCAGAGATCGTTTGCACTTCGTGTTATAATCCCCTAATTGTGTCGCCAGAGCGGCCTGTT
TCCACGTTGAGTATGAGACA

Downstream 100 bases:

>100_bases
AAGCCATCTCACACTGTGGCGTTAACCGGTGTGAAGTGAGTAAAGATTTCCCGCAGAAAATGGCGGTAAACGATGAAAAT
GGTACTCAGTACAAAATGTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR

Sequences:

>Translated_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
>Mature_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=32.8125, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI226371618, Length=350, Percent_Identity=35.1428571428571, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=39.375, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=26.8456375838926, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=26.8456375838926, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=88.962472406181, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=35.0943396226415, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=453, Percent_Identity=30.0220750551876, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=28.6184210526316, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=31.0810810810811, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=26.8370607028754, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=29.7297297297297, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=27.7272727272727, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49781; Mature: 49781

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKNELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAQGVGIDFFPSDAQEKPIDIVNRALQQAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLATKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKRRIATGSGVQVQDVNRLLKQF
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKNELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAQGVGIDFFPSDAQEKPIDIVNRALQQAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLATKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKRRIATGSGVQVQDVNRLLKQF
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]