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The map label for this gene is btuC

Identifier: 153948990

GI number: 153948990

Start: 1989343

End: 1990350

Strand: Direct

Name: btuC

Synonym: YpsIP31758_1720

Alternate gene names: 153948990

Gene position: 1989343-1990350 (Clockwise)

Preceding gene: 153946895

Following gene: 153949548

Centisome position: 42.12

GC content: 48.61

Gene sequence:

>1008_bases
ATGCAGACAAGTCAGTTATTTACCGCACTTCAACAACGGCAGCGGCAGCGCGACTATCGTTATCTTACTGGGCTGGTTGT
CATGCTTTTGTTCGCGCTACTCATCAGTTTATGTGCGGGTGATGTCTGGATTTGGCCAGAGCACTGGTTCAGTGAAAGTG
GCAAATTATTTGTTTGGCAACTACGTTTGCCCCGATCTATGGCTGTAATTATGGTTGGTGCCAGTCTGGCCGTGTCGGGT
GCTGTGATGCAGGCACTGTTTGAAAATCCGTTAGCTGAACCGGGTCTACTTGGCGTGGCAAATGGCGCAGGTGTTGCATT
GGTGACGGCCGTATTATTAGGTCATGGATTATTGCCAATTTGGGTTCTGAGCACGTGTGCTATTATTGGCGCATTGTTGA
TGACATCTATTCTGTTAAGTTTCACCCGTCGCCGTTTATTAACTAATGCCCAGCTATTATTGGTCGGTGTAGCCTTAGGT
ATTATTTGCAGTGCAATGATGACTTGGGCCGTCTATTTCAGCACCAGTTTGGATTTACGTCAGCTCATGTATTGGATGAT
GGGGGGGTTCAGCGGTGTTGACTGGCGTCAGCAAAGTTTGGTGCTGGCTCTCTTGCCTACCGTCATATGGCTTTGCTGCC
AAGGCCGTGTCCTGAACTTCATGTCACTCGGTGAGCAGCAGGCCAGGCAATTGGGGGTGTCGCTTCATTTATGGCGGAAT
TTATTAGTACTGGCGATCGGATTACTGGTCGGCATTAGTGTTGCACTCGCGGGTGTCATCAGTTTTATTGGCTTGGTTAT
TCCTCATATTTTACGGTTAACCGGTTTAACTGATCAGCGCCGGCTATTAGCGGGCTGTGCATTCGCCGGCGGGGGGGTAT
TATTATTAGCTGATGTTGTCGCTCGCACGGTATTATCTTCGGCAGAGCTACCGATTGGTGTGGTTACCGCAACATTAGGA
TCGCCATTATTTATCTGGTTACTGATACGGGTGAAAGGAGTAAAGTGA

Upstream 100 bases:

>100_bases
CGCTCTAACCCCCTAATATCAGTGCCTGAGAATGGGCAGTAGGCCCTTGTATGTTTACCCGACCTATTCGGGTAAGTCTT
GGGTAATGGCCGAGGGTGTA

Downstream 100 bases:

>100_bases
TTTGTCTTCTTATAAATGCCGCGGTGATTTTACCGGTTTATTATCATTACTGAATAAGGATCCAACCTGATGAGTCACCC
AATTTACGCCATTTCAGTGC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSG
AVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALG
IICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRN
LLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLG
SPLFIWLLIRVKGVK

Sequences:

>Translated_335_residues
MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSG
AVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALG
IICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRN
LLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLG
SPLFIWLLIRVKGVK
>Mature_335_residues
MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSG
AVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALG
IICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRN
LLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLG
SPLFIWLLIRVKGVK

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily

Homologues:

Organism=Escherichia coli, GI1788004, Length=325, Percent_Identity=68, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790740, Length=293, Percent_Identity=36.518771331058, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=33.6879432624113, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1786347, Length=324, Percent_Identity=30.2469135802469, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786805, Length=282, Percent_Identity=35.4609929078014, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786804, Length=290, Percent_Identity=32.4137931034483, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BTUC_YERP3 (A7FHG9)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400697.1
- ProteinModelPortal:   A7FHG9
- SMR:   A7FHG9
- STRING:   A7FHG9
- GeneID:   5384829
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1720
- eggNOG:   COG4139
- HOGENOM:   HBG700016
- OMA:   CAGDQWI
- ProtClustDB:   PRK03784
- BioCyc:   YPSE349747:YPSIP31758_1720-MONOMER
- HAMAP:   MF_01004
- InterPro:   IPR000522

Pfam domain/function: PF01032 FecCD

EC number: NA

Molecular weight: Translated: 36332; Mature: 36332

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f3b74a4)-; HASH(0x200b5bcc)-; HASH(0x200b0854)-; HASH(0x200acf70)-; HASH(0x200b5b00)-; HASH(0x20083080)-; HASH(0x1fc26284)-; HASH(0x1fff42d8)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHCCCCCEEEEE
LRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPI
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCHHHH
WVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
QLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRN
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCHHHHHHHH
LLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
ARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCH
>Mature Secondary Structure
MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHCCCCCEEEEE
LRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPI
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCHHHH
WVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
QLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRN
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCHHHHHHHH
LLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
ARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA