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The map label for this gene is ggt [H]

Identifier: 153948785

GI number: 153948785

Start: 3518608

End: 3520371

Strand: Direct

Name: ggt [H]

Synonym: YpsIP31758_3128

Alternate gene names: 153948785

Gene position: 3518608-3520371 (Clockwise)

Preceding gene: 153948130

Following gene: 153949199

Centisome position: 74.49

GC content: 50.28

Gene sequence:

>1764_bases
ATGTTTTTAACGAAATGGAATAAGCCATTAGCAGTATTAGCTTTACTGGTAAGTGGCACGCTGCATGCTGCCTCCACACC
TGCGGTAGAAACGAAAAATGGCATGGTTGTGACCTCCCAATATCTGGCTTCACAGGTTGGGGCAGATATTTTAAAAATGG
GCGGTAATGCTGTTGATGCCGCAGTAGCGGTAGGATATGCCCAGGCAGTAGTCAATCCTTGCTGTGGCAATATTGGCGGA
GGTGGTTTTATGACCATTCATCTTGCCGATGGAACCGATACATTTATTAACTTTCGTGAAACCGCCCCTTCCACGGCTAA
TGCTGATATGTACTTGGATAAAGACGGTAACGTTACCAAGGATGCCAGTTTGTATGGCTATCTGGCGGTAGGTGTACCTG
GCACGGTATTGGGCATGGATAGTGCGCAAAAGAAATACGGCAAATTAACCCGTCAGCAAGTCATGGCACCGGCTATCCGT
TTGGCCCGTGACGGCTTTATCCTGACTCGCGCCGATACCGATATTCTGGACACCACCGTCAAACGTTTCCGTCAGGATCC
TGAGTCTGCACGTATCTTCCTGCGTAAAGATGGAGAGGCACTACAACCGGGCGATCGTCTGGTTCAGGCCGATCTCGCGG
ATACGTTAAGTGCGATTTCAGAAAAAGGGCCGGATGCGTTCTATCAAGGTAAAATACCGCAAGCTGTGGAAGCAGCGGCT
AAAAAGGGAGGCGGGATACTGACTGCCGCCGATTTCGCCGATTATAAAATCACCGAAACCGCACCGATTACCTGTAGTTA
TCGCGGTTATAAATTCGTTTCAGCCCCACCGCCGAGTTCCGGTGGCGTCACATTATGTGAAACGCTAAATGTTTTGGAGG
GCTATAACCTCAAAAGTATGGGCTTTAACTCCGCTGACTATATCCATACGCTAACGGAGGCAATGCGCCACGCCTATATG
GACCGCAATACCTTCCTCGGTGATCCAGAGTTTGTTAAAAATCCGCTTGACCGCCTACTGAGCAAAAGCTACGCCGCCGA
TATCCGTAAACAGATCGTCGCCAACAAAGCAACACCATCAGTAGAAGTACAACCGGGTATGCAACCTCACGAAAAACCGG
AGACGACACACTACTCCATCGTCGATCATGAGGGTAATGCCGTTTCTACCACGTATACCGTTAATGGGCGCTTTGGAGCG
GTGGTCATTGCTCCTGGTACTGGCTTCTTCCTCAATAATGAAATGGATGATTTTACAGTTAAAGTTGGTGAACAAAATCT
GTATGGATTGGTACAAGGTGCAACCAACGCTATCGCCCCCAGTAAGCGCCCACTATCGTCAATGAGCCCGACACTAGTGA
CCAAAGATGGAAAAACATTTATGGTCTTGGGTTCACCGGGTGGCTCACGGATTATCAGCATCACGCTGCAAACCGCCCTG
AACGTCATTGACCACGGTATGGCCCCGCAAGAAGCGGTTGATGCACCACGTATTCACCATCAGTGGCTACCCGATGAAGT
CTATTATGAGCAACGCGGTGTCTCAGCGGACAGTCTCAATATCCTGAAGAATATGGGGTATAAGATGGTTGAACAGAGCC
CTTGGGGCGCAGCGGAGTTGATTTTAGTCGGCCTGGCCGGTGTTGAGGGCGTCAGCCCGGCTAACTCGGGTAATGATTCT
GCTGTCTCCGGCAAAGTCCGTGAGGGCTACCTGTACGGTGCCAATGATGTCCGTCGCCCCGCAGGGGCTGCTATTGGCTA
CTAA

Upstream 100 bases:

>100_bases
ACAAATTTTTTATATTCCACATACAAAGCAGCGTTTTTAGTGCTGCCAGACAACGATGACCGGGTAACTCCCGGCAGGCA
GGAGCACAATAGGAGTTCGT

Downstream 100 bases:

>100_bases
TCAATCTAATGACTACTAATCAATCTAATGACTACTAATCAATCTAATGGCTACTAATCAATCTAATGGTTGTTAATTAA
GATTAAGCCATGGGTCGTTA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVETKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPSKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKNMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY

Sequences:

>Translated_587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVETKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPSKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKNMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY
>Mature_587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVETKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPSKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKNMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=478, Percent_Identity=34.5188284518828, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI73915090, Length=478, Percent_Identity=34.5188284518828, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI73915096, Length=478, Percent_Identity=34.5188284518828, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI73915094, Length=478, Percent_Identity=34.5188284518828, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI113429324, Length=479, Percent_Identity=33.1941544885177, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI113429326, Length=484, Percent_Identity=32.6446280991736, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=30.3675048355899, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI153266885, Length=477, Percent_Identity=29.559748427673, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI153266901, Length=478, Percent_Identity=29.4979079497908, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI153266907, Length=476, Percent_Identity=28.1512605042017, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI30581157, Length=177, Percent_Identity=38.4180790960452, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI30581155, Length=177, Percent_Identity=38.4180790960452, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=32.7586206896552, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=29.8850574712644, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=48.5714285714286, Blast_Score=523, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI212646519, Length=482, Percent_Identity=35.0622406639004, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI72000294, Length=482, Percent_Identity=35.0622406639004, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17506189, Length=499, Percent_Identity=32.6653306613226, Blast_Score=238, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=508, Percent_Identity=33.6614173228346, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193208245, Length=505, Percent_Identity=32.8712871287129, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193208247, Length=505, Percent_Identity=32.8712871287129, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17564448, Length=431, Percent_Identity=27.3781902552204, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI72001497, Length=378, Percent_Identity=25.1322751322751, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=246, Percent_Identity=26.0162601626016, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=512, Percent_Identity=30.2734375, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI161077880, Length=510, Percent_Identity=31.1764705882353, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45551474, Length=510, Percent_Identity=31.1764705882353, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24642670, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642666, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161077878, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161077496, Length=510, Percent_Identity=31.7647058823529, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI18859893, Length=536, Percent_Identity=30.9701492537313, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI18859741, Length=517, Percent_Identity=28.4332688588008, Blast_Score=192, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62568; Mature: 62568

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLTKWNKPLAVLALLVSGTLHAASTPAVETKNGMVVTSQYLASQVGADILKMGGNAVDA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCC
DASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLARDGFILTRADTDILDTTV
CCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
KRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSM
HCCCCEEEECCCCCEEEECCCCEEEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCCC
GFNSADYIHTLTEAMRHAYMDRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVIAPGTGFFLNNEMDDFTV
EEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEQNLYGLVQGATNAIAPSKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
EECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKNMGYKMVEQSPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHEECCCCCCHHHE
ILVGLAGVEGVSPANSGNDSAVSGKVREGYLYGANDVRRPAGAAIGY
EEEEECCCCCCCCCCCCCCCCCCCCEECCEEECCCHHCCCCCCCCCC
>Mature Secondary Structure
MFLTKWNKPLAVLALLVSGTLHAASTPAVETKNGMVVTSQYLASQVGADILKMGGNAVDA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCC
DASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLARDGFILTRADTDILDTTV
CCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
KRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSM
HCCCCEEEECCCCCEEEECCCCEEEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCCC
GFNSADYIHTLTEAMRHAYMDRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVIAPGTGFFLNNEMDDFTV
EEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEQNLYGLVQGATNAIAPSKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
EECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKNMGYKMVEQSPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHEECCCCCCHHHE
ILVGLAGVEGVSPANSGNDSAVSGKVREGYLYGANDVRRPAGAAIGY
EEEEECCCCCCCCCCCCCCCCCCCCEECCEEECCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]