Click here to switch to the map view.

The map label for this gene is tyrB [H]

Identifier: 153948630

GI number: 153948630

Start: 4240329

End: 4241522

Strand: Reverse

Name: tyrB [H]

Synonym: YpsIP31758_3763

Alternate gene names: 153948630

Gene position: 4241522-4240329 (Counterclockwise)

Preceding gene: 153948196

Following gene: 153946919

Centisome position: 89.8

GC content: 50.42

Gene sequence:

>1194_bases
GTGTTCCAGAATGTTGACGCCTACGCAGGTGACCCCATCCTTTCACTGATGGAAAGTTTTAAAGCCGATAACCGGGCACA
TAAGGTGAATCTGAGTATTGGGCTTTATTACAATGAACAAGGTGAAATCCCGCAAATGCAGGCTGTGGATGCTGCCGAAG
CGCAATTGAGTACTCAACCTCATGGGACACCGGTTTATTTACCGATGGAAGGTCTGCAATCTTACCGTACTGCTATCCAG
CAATTATTATTTGGTCACGACCATCTAATGCTGGTTCAGCAACGGGTGGCGACAATACAGACGGTGGGCGGTTCTGGTGC
GTTGAAAGTCGGGGCTGATTTCCTTAATCACTATTTCCCTGATTCACAGGTGTGGGTCAGCGATCCTACCTGGGAAAACC
ACGTGGCTATTTTTAGCGGCGCAGGTTTTAAAGTGAACACCTATCCGTATTTCGACAATGATAAGCTGGCGGTGAAGTTT
GACCCGATGCTGGCAACCTTGCAGCAATTGCCCGCCAGAAGCATCGTGTTGTTACATCCTTGCTGCCACAATCCAACCGG
TTCTGATCTGACCAATGCCCAATGGGATCGCCTCATTGATGTGGTAAAAGAGCGTGAACTGATCCCGTTCCTGGATATAG
CGTACCAAGGCTTTGGGGCAGGGCTGAATGAAGATGCTTATGCTATCCGCGCTATGGCCGCAGCTGGATTGCCATGCCTC
ATCAGCAACTCCTTCTCAAAAATCTTCTCGCTCTATAACGAGCGGGTCGGTGGTTTATCTGTGGTGTGTGAAAGTGACGA
GGCCGCAGGGCGTGTATTGGGCCAATTGAAAGCGACAGTGCGCCGTAACTATTCCAGCCCGCCAAACTTTGGTGCGCAGG
TCGTTTCGAAAGTCCTAAATGATACGGTATTGCGCGCGCAATGGCAGGCAGAGGTGGAACAGATGCGCCTACGGATCCTT
GATATGCGCCACACGCTGGTGGAAGCCTTAAAAGCCTCGTTACCAGAGCGCAATTTTGATTATCTGTTGCAACAACGCGG
CATGTTCAGCTACACCGGCTTTAGTGAGGCACAGGTAGATCGCTTACGTGAAGAGTTTGGTGTGTATCTGATTGCGAGCG
GAAGAATGTGTATGGCGGGAGTCAATCACCAGAATGTTGAGCAGGTTGCGGTTGCTTTTGCGGCGGTACAGTAA

Upstream 100 bases:

>100_bases
CTTACTCATGTAAGCCCTAGGAGGGCCGCTCCGTTGCCGCCTTTCTGCAACTCGGATGATTGCAGGTATAGAATTATTAT
CAATTTAGGAGAGCAGCACC

Downstream 100 bases:

>100_bases
TGTTCAGCCTTTAACCGCGGGCAAACGGGTGGCCACAATAAAATAAGCAGGCAGTAAGATATTGATATCGCCCATGGAAG
GGCCGCTATATTTTTACGGC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHLMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Sequences:

>Translated_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHLMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
>Mature_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHLMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=397, Percent_Identity=38.5390428211587, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI4504067, Length=387, Percent_Identity=39.2764857881137, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI117414139, Length=378, Percent_Identity=27.7777777777778, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=76.2626262626263, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=42.9292929292929, Blast_Score=347, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=37.3737373737374, Blast_Score=297, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI25147133, Length=387, Percent_Identity=38.5012919896641, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17569539, Length=368, Percent_Identity=39.1304347826087, Blast_Score=273, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=31.2020460358056, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=35.9848484848485, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=35.377358490566, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=404, Percent_Identity=36.6336633663366, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=33.0188679245283, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI19922362, Length=385, Percent_Identity=40, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24654046, Length=385, Percent_Identity=40, Blast_Score=297, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=37.7833753148615, Blast_Score=287, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=37.7833753148615, Blast_Score=287, Evalue=7e-78,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.1443298969072, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44076; Mature: 44076

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHLMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHLMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]