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The map label for this gene is rdgB [C]

Identifier: 153948234

GI number: 153948234

Start: 1005738

End: 1006331

Strand: Reverse

Name: rdgB [C]

Synonym: YpsIP31758_0826

Alternate gene names: 153948234

Gene position: 1006331-1005738 (Counterclockwise)

Preceding gene: 153948675

Following gene: 153949486

Centisome position: 21.31

GC content: 53.2

Gene sequence:

>594_bases
ATGCAAAAAATAGTATTAGCCACCGGCAACCCCGGCAAAGTACGTGAACTGGCAAACCTGCTGGCCGACTTTGGTTTGGA
TGTCGTCGCACAAACCGAACTGGGTGTTGAGTCTGCAGAAGAGACGGGCTTAACCTTTATTGAAAACGCCATTTTAAAAG
CCCGCCATGCAGCGCAAACCACCGGTTTACCGGCCATCGCCGATGATTCAGGCTTAGCAGTAGACGCGTTAGGCGGCGCT
CCGGGGATTTATTCCGCACGCTATGCCGGTACTGATGCCAGTGACCAAGAGAATCTGGAAAAGCTGTTGGCCGCATTGCA
AAATGTCCCCGAGGAAAAACGCGGTGCTCAGTTCCATTGCGTATTGGTCTATATGCGTCATGCTGAAGATCCAACACCGC
TGGTGTTCCATGGCCAATGGCCAGGGGTAATTGCTCACCAACCTGCTGGGGCTGCTGGGTTTGGCTATGACCCTATTTTC
TATGTACCCGCGCTGGGTAAAACCGCAGCGGAACTGACACGTGAAGAAAAGCACGCGGTATCCCATCGTGGTCAGGCCCT
GAAATTGATGCTGGATGCGCTGCGCGATGCTTAA

Upstream 100 bases:

>100_bases
AGTTGATATTCCTCCGCGAGAATTGGGTTATTGGTTGTCAGCCCAACAGACTGTGCTCAATACCGATAGCCGTCAGCCCA
TAAAAATTCAGGATTCATCG

Downstream 100 bases:

>100_bases
ATTACCCCCGCTCAGTCTCTACATCCATATCCCTTGGTGCGTCCAGAAATGCCCTTATTGTGATTTCAACTCACATGCGT
TGAAAGGCGATGTCCCTCAT

Product: deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLAALQNVPEEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Sequences:

>Translated_197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLAALQNVPEEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA
>Mature_197_residues
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGA
PGIYSARYAGTDASDQENLEKLLAALQNVPEEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIF
YVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=189, Percent_Identity=33.8624338624339, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=79.0816326530612, Blast_Score=332, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17556833, Length=197, Percent_Identity=28.9340101522843, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19920712, Length=190, Percent_Identity=33.6842105263158, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 20892; Mature: 20892

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQT
CCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHCHHHHHHHHHHHHHHHHH
TGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLAALQNVPEEKRGAQFHC
CCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHCCEEEE
VLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAV
EEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
SHRGQALKLMLDALRDA
HHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQT
CCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHCHHHHHHHHHHHHHHHHH
TGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLAALQNVPEEKRGAQFHC
CCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHCCEEEE
VLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAV
EEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
SHRGQALKLMLDALRDA
HHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]