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The map label for this gene is ndk

Identifier: 153947813

GI number: 153947813

Start: 1393004

End: 1393432

Strand: Direct

Name: ndk

Synonym: YpsIP31758_1182

Alternate gene names: 153947813

Gene position: 1393004-1393432 (Clockwise)

Preceding gene: 153947358

Following gene: 153948736

Centisome position: 29.49

GC content: 48.48

Gene sequence:

>429_bases
ATGGCTTTAGAACGTACTTTCTCGATTATCAAACCAAACGCTGTTGCCAATAACAACATCGGTGCCATTTATGCGCGTTT
TGAAAGTGCTGGTTTCAACATCATCGCCGCAAAGATGTTGCACCTGACTAAAGAACAGGCCGAAGGTTTTTACGCTGAAC
ATAAAGGCCGCCCGTTCTTCGATGGTTTGGTTGAGTTTATGACCTCTGGCCCCATTATGGTTCAGGTTCTGGAAGGCGAA
AATGCAGTACAGCGCCATCGCGATATCATGGGGGCGACTAACCCAGATAATGCGCTGGCCGGTACGCTACGTGCTGATTT
TGCCGACAGCTTCACCGCGAATGCGGTACATGGCTCTGATGCTGTTGAATCTGCTCAACGCGAAATCGCGTATTTCTTTG
CGGCAGATGAAATTTTTCCCCGTAGCTAA

Upstream 100 bases:

>100_bases
CATCATTTTAGTGTAAAGGAACGGGCTGCCAGCCAAGTAAATACGCTTATCAGAGCAGGTTCCGAGTCCGGTTAATATTA
GATATCCAATAGAGGTTATT

Downstream 100 bases:

>100_bases
TGCGTTAATTTAAGCGACTAGTGGGTTGATTCAATGCAGGAAAGTGGGGGGATTTAATCAACTGAAACAATAAAGTTGCC
CAGACCCGTTTCCATTCATG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIMVQVLEGE
NAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS

Sequences:

>Translated_142_residues
MALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIMVQVLEGE
NAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS
>Mature_141_residues
ALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIMVQVLEGEN
AVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.8529411764706, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.9117647058824, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.9117647058824, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.037037037037, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=41.9117647058824, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=34.0740740740741, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=34.0740740740741, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=33.8129496402878, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=35.7664233576642, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=77.4647887323944, Blast_Score=233, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=44.4444444444444, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=43.7037037037037, Blast_Score=131, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=47.4074074074074, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=38.0597014925373, Blast_Score=93, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_YERP3 (A7FFY5)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400163.1
- ProteinModelPortal:   A7FFY5
- SMR:   A7FFY5
- STRING:   A7FFY5
- GeneID:   5385871
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1182
- NMPDR:   fig|349747.3.peg.1364
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   YPSE349747:YPSIP31758_1182-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15531; Mature: 15399

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFF
CCCCCCHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHH
DGLVEFMTSGPIMVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
AVESAQREIAYFFAADEIFPRS
HHHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure 
ALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFF
CCCCCHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHH
DGLVEFMTSGPIMVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
AVESAQREIAYFFAADEIFPRS
HHHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA