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The map label for this gene is dmsA [H]

Identifier: 153947792

GI number: 153947792

Start: 3668496

End: 3670946

Strand: Reverse

Name: dmsA [H]

Synonym: YpsIP31758_3261

Alternate gene names: 153947792

Gene position: 3670946-3668496 (Counterclockwise)

Preceding gene: 153948202

Following gene: 153947293

Centisome position: 77.72

GC content: 52.92

Gene sequence:

>2451_bases
ATGAAAGAGACCAACGAATCCCGGCTGTTAACGACAGGTGTCACCCGCCGAAAACTGGTCCAAACCACGCTTGTCGGCGG
ACTGGCTATGGCAACCGGGGCGTTTTCGTTACCGTTCTCCCGTACCGCACGAGCCGTTCAATCCGCATTCAACCCCACCT
CAGCCAACGACGGTAAAGTGATCTGGAGCGCCTGCACCGTTAACTGCGGCAGCCGCTGCCCGCTGCGTATGCATGTGGCT
GAGGGCGAAATCAAATATGTCGAAACGGATAACACCGGTGATGATAATTTTGAGGGGCTACACCAGGTACGCGCCTGTCT
GCGAGGGCGGTCTATGCGCCGCCGGGTCTATAACCCAGACCGCTTAAAATACCCGATGAAACGAATCGGTGCCCGTGGTG
AAGGGAAATTCAAACGTATCTCGTGGGAAGAGGCATTCGAGACTATCGCTGGCAGCATGCAGAATATTATCAAGGAATAT
GGCAATGAAGCCATTTACCTGAACTACGGTACCGGCACGATAGGCGGCACCATGACCCGCTCTTGGCCGCCGGGCGCGAC
GCTCTTGGCTCGCTTGATGAATTGCTGCGGTGGCTACCTCAACCAGTATGGTGATTACAGTACCGCACAGATTGCCGCGG
GACTCAATTATACCTACGGTGGCTGGGCTGACGGTAACAGCCCGTCCGATATCGAAAACAGTAAGCTGGTGGTGTTGTTC
GGTAATAACCCGGCTGAAACCCGGATGAGTGGCGGTGGGGTCACCTATTATCTGGAACAGGCGCGCGAGAAATCCAATGC
CAAAATGATCGTGATTGATCCCCGTTATACCGACACCGCCGCAGGCCGTGAAGATGAATGGATCCCGCTACGACCGGGCA
CTGATGCCGCATTGGCCTCTGCGTTAGCCTATGTGATGATCACTGAAAATCTGGTGGATCAACCCTTCCTCGACCAATAT
TGCGTTGGTTATGACGAGAAAACTCTGCCAGAAGGCGCACCCGAAAATAGCCACTACAAAGCTTATATTTTAGGGCAGGG
CGCAGATAAAACCGCCAAAACCCCACAATGGGCTGCGGCTATCACCGGTATTCCCGCTGCAAAAATCATTACGCTAGGCC
GTGAAATAGGGTCGGTGAAGCCGGCTTATATTTCCCAAGGTTGGGGGCCACAACGTCATTCCAACGGCGAAAACACCAGC
CGGGCCATTGCCATGTTGGCAATCTTGACCGGTAATGTCGGCATTAATGGCGGTAACTCCGGTGCTCGCGAAGGTTCCTA
CAGTTTGCCGTTTGTCCGTATGCCTACCTTTGAAAACCCAGTCAAAACCAGTATCTCTATGTTCTTGTGGACCGATGCCA
TTGAGCGTGGGCCTGAAATGACCGCCACCCGTGATGGGGTTCAGGGGAAAGATAAGCTGGATGTCCCGATCAAATTTATT
TGGAACTACGCCAGTAACTGTTTGGTGAATCAGCATTCTGAAATCAACCGTACCCATGACATTCTGCAAGACGATAAGAA
ATGCGAAATGATTGTGGTCATTGATAACCACATGACCTCGTCGGCTGAATATGCCGATATTATCCTGCCAGACTGTACCG
CCTCCGAGCAGATGGACTTCTGTCTGGATGCCTCCAGCGGCAATATGGCCTATGTCATTTTTGCTGATCAGGTGATTAAA
CCGCGTTTTGAGTGCAAAAATATTTATGACATCACCAGTGGATTGGCAAGACACATGGGGGTCGAGCAGAAGTTTACCGA
AGGGCGAACGCAAGAAGAGTGGATGCGCCACCTCTACCAGCAATCGCAAGCTGCAATCCCTGAACTGCCTTCTTTCGAGG
ATTTCCGCGCTCAGGGCATGTTTAAAAAACGTGACCCGGCAGGCCATCACGTTGCCTATCACGATTTCCGCACCGATCCG
GTTGCTAACCCACTGAGTACCCCATCAGGCAAAATTGAGATCTATTCTGCGGCGCTGGCCGAGATTGCCGCGACTTGGGA
ACTGCAAAAAGATGATGTTATCGATCCGTTGCCCGTATATGCCGCCGGTTTTGAAAGCCATGTTGATCCACTGATCGAAC
AGTATCCGTTGCAATTAACCGGCTTCCACTACAAGGCCAGAACCCACTCCACCTACGGTAATGTAGATGTGTTGAAAGCC
TCCTGTCTTCAGGAGATGTGGATTAACCCGATGGATGCCGAACGGCGAGGGATCAGCAATGGCGATATGGTGCGGATCTT
CAATGGCCGTGGTGAAGTACAGATTAATGCCAAAGTCACTCCGCGCATGATGCCGGGGGTTGTCGCTTTGGGTGAGGGGG
CGTGGTACAGCCCCGATGCGAAGCGTATTGATCGGGCGGGCAGTATCAACGTATTGACCACCCAGCGCCCCTCCCCGTTG
GCGAAAGGGAACCCATCCCACACCAACCTCGTTCAAGTCGCCAAGGCATAA

Upstream 100 bases:

>100_bases
CCCCAATCTCCTGCTGATCTGCTCATTTTTTTTGAATTATTCGGGCGCCATCCGCACTGGGTGACTCTCATTTTCTGGAA
TGCAACTAAGTGGGAATCTT

Downstream 100 bases:

>100_bases
GGAGCTGACTGATGACAACGCAATATGGTTTTTACATCGACTCCAGCCGTTGTACGGGGTGTAAAACGTGCGAGCTGGCT
TGCAAAGACTTTAAAAATCT

Product: anaerobic dimethyl sulfoxide reductase, A subunit

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSAFNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA

Sequences:

>Translated_816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSAFNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA
>Mature_816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSAFNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=816, Percent_Identity=81.4950980392157, Blast_Score=1401, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=810, Percent_Identity=66.1728395061728, Blast_Score=1133, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=819, Percent_Identity=63.1257631257631, Blast_Score=1092, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.6688567674113, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI145693196, Length=755, Percent_Identity=30.4635761589404, Blast_Score=280, Evalue=4e-76,
Organism=Escherichia coli, GI87081994, Length=745, Percent_Identity=31.2751677852349, Blast_Score=276, Evalue=4e-75,
Organism=Escherichia coli, GI3868721, Length=761, Percent_Identity=25.4927726675427, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI3868720, Length=472, Percent_Identity=27.7542372881356, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1787477, Length=302, Percent_Identity=27.8145695364238, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1787741, Length=308, Percent_Identity=26.9480519480519, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI3868719, Length=479, Percent_Identity=25.2609603340292, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788534, Length=811, Percent_Identity=22.8113440197287, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89952; Mature: 89952

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSAFNPTSANDGKV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IWSACTVNCGSRCPLRMHVAEGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPD
EEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCH
RLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEYGNEAIYLNYGTGTIGGTMTR
HHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALAS
CCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHH
ALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAA
HHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNVGINGGNS
HCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
CCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
WNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDF
HHHHHHHEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCE
CLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQ
EEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
QSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIEIYSAALA
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHHH
EIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
HHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHH
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDA
HHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCCH
KRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSAFNPTSANDGKV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IWSACTVNCGSRCPLRMHVAEGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPD
EEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCH
RLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEYGNEAIYLNYGTGTIGGTMTR
HHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALAS
CCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHH
ALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAA
HHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNVGINGGNS
HCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
CCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
WNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDF
HHHHHHHEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCE
CLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQ
EEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
QSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIEIYSAALA
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHHH
EIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
HHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHH
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDA
HHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCCH
KRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]