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The map label for this gene is copR [H]

Identifier: 153947115

GI number: 153947115

Start: 2393996

End: 2394688

Strand: Direct

Name: copR [H]

Synonym: YpsIP31758_2084

Alternate gene names: 153947115

Gene position: 2393996-2394688 (Clockwise)

Preceding gene: 153950433

Following gene: 153948780

Centisome position: 50.68

GC content: 52.24

Gene sequence:

>693_bases
ATGCGGCTATTGTTGGTAGAAGATGAGGAGAAGACATCTTCGTATATCAATCGCGCCCTCAGCGAGTTGGGCTTTACCGT
CGATGTAGCGGCCACCGGGATCGACGGATTATATCTGGCTCTTGAGTATGATTACGATACGATTGTGCTCGATGTCATGT
TGCCCGGCATGGATGGTTACAGCGTTCTCGAAGGCCTACGCGCCAGCAAACAAACTCCGGTTCTGATGTTATCCGCCCGT
GGCTCGGTTGATGAACGAGTTAAGGGCCTGCGTCACGGTGCCGACGATTATTTGCCTAAGCCTTTTTCGCTGATTGAACT
GGTTGCGCGTATCCAGGCGTTGTTGAGGCGGCGTCCCAGTGATGGTGTAGATGTCAGCCAATTGCACATTAATGATCTAC
ATCTCGACCTGCTGGCAAGGCGTGTCACGCGAGCCGGTGAACGTCTTGAACTCACCGCCAAAGAGTTCGCCCTGTTAAGC
CTGTTAGCCAGACATCAGGGGGAAATTCTGTCAAAAATGATGATTGCAGAGCAGGTCTGGGACATGAATTTTGACAGCGA
TGCCAATGTCGTTGAGGTGGCGATAAAACGCCTGCGGGCGAAAATAGATACGCCCTACCCGGTCAAACTGCTGCATACAG
TGCGAGGCATGGGGTATGTCCTTGAAACTCGCCCCGAACGCCAGACTAAATAG

Upstream 100 bases:

>100_bases
CAAAAATGTCAGGAAAATGTCAGCCTGGTGTTGGTCATGAACAGCTAAGATAGGTGAAATGCGATTTTTGTTGCCCTGAC
GGGTAAAGGGAGAGACGAAC

Downstream 100 bases:

>100_bases
AGAGAGTGATCATGATTAAGCGTTCTATCTCTGGGCGGCTGGCGCTAATGTTTGCCTTGGCCTCCATACTGATAGTTTCG
GCTCTCGGTATTGTACTGCG

Product: DNA-binding heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPERQTK

Sequences:

>Translated_230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPERQTK
>Mature_230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPERQTK

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=52.8384279475983, Blast_Score=251, Evalue=3e-68,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=52.0547945205479, Blast_Score=237, Evalue=4e-64,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=43.2432432432432, Blast_Score=163, Evalue=8e-42,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=37.4449339207048, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.8854625550661, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.0044052863436, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=34.4036697247706, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.034632034632, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=30.1801801801802, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=28, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=38.6138613861386, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=30.6306306306306, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25889; Mature: 25889

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGY
CEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCEEEEEEEECCCCHH
SVLEGLRASKQTPVLMLSARGSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLSLLARHQGEILSKMMIAEQVW
CCCCHHEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPERQTK
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGY
CEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCEEEEEEEECCCCHH
SVLEGLRASKQTPVLMLSARGSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLSLLARHQGEILSKMMIAEQVW
CCCCHHEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPERQTK
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]