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The map label for this gene is hns [H]

Identifier: 153947038

GI number: 153947038

Start: 2268426

End: 2268833

Strand: Direct

Name: hns [H]

Synonym: YpsIP31758_1966

Alternate gene names: 153947038

Gene position: 2268426-2268833 (Clockwise)

Preceding gene: 153948652

Following gene: 153950321

Centisome position: 48.03

GC content: 43.87

Gene sequence:

>408_bases
ATGAGCGAAGCGTTAAAAATTCTTAACAACATCCGTACTCTACGTGCTCAAGCGCGCGAATGCACTCTTGAAACACTAGA
AGAAATGCTTGAGAAGCTTGAAGTGGTCGTTAATGAACGCCGCGAAGAAGAATCTCAATCACAAGCAGAAATTGAAGAGC
GTGCACGTAAATTGCAACAATACCGTGAAATGCTTATTGCTGACGGTATTGATCCAAATGAACTGCTACAAGCTTCAGCT
GCTGCTAAAGCTGCTGGTAAAGCAAAACGTGCTGCACGTCCTGCTAAATATCAGTATAAAGATGAGAATGGCGAACTGAA
AACTTGGACAGGCCAAGGCCGTACTCCTGCAGTGATTAAGAAGGCCATTGAAGAGCAAGGCAAATCACTGGATGACTTCC
TGTTGTAA

Upstream 100 bases:

>100_bases
AATTCTAGTATGCTAATCAAATTGGCTATTGCAGAAATTAAAATAGCACTCTATTATTATCCAGACGCCCCCCCACCAAT
TATAATTTGAGACTAGGACA

Downstream 100 bases:

>100_bases
TAGTTTTATTTCTTTAGCTATTACTATCGAAACACCCTCCTATTAATAGGAGGGTGTTTTTTGTGCCCAGAAAACCCCCA
GCTAGGCTGGGGGTTCAGTA

Product: global DNA-binding transcriptional dual regulator H-NS

Products: NA

Alternate protein names: Histone-like protein HLP-II [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESQSQAEIEERARKLQQYREMLIADGIDPNELLQASA
AAKAAGKAKRAARPAKYQYKDENGELKTWTGQGRTPAVIKKAIEEQGKSLDDFLL

Sequences:

>Translated_135_residues
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESQSQAEIEERARKLQQYREMLIADGIDPNELLQASA
AAKAAGKAKRAARPAKYQYKDENGELKTWTGQGRTPAVIKKAIEEQGKSLDDFLL
>Mature_134_residues
SEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESQSQAEIEERARKLQQYREMLIADGIDPNELLQASAA
AKAAGKAKRAARPAKYQYKDENGELKTWTGQGRTPAVIKKAIEEQGKSLDDFLL

Specific function: H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its abilit

COG id: COG2916

COG function: function code R; DNA-binding protein H-NS

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone-like protein H-NS family [H]

Homologues:

Organism=Escherichia coli, GI1787489, Length=135, Percent_Identity=85.9259259259259, Blast_Score=209, Evalue=5e-56,
Organism=Escherichia coli, GI1789023, Length=136, Percent_Identity=61.7647058823529, Blast_Score=137, Evalue=3e-34,

Paralogues:

None

Copy number: 820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1780 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 1020 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 4632 Molecules/Cell In: Gr

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001801 [H]

Pfam domain/function: PF00816 Histone_HNS [H]

EC number: NA

Molecular weight: Translated: 15317; Mature: 15185

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESQSQAEIEERARKLQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLIADGIDPNELLQASAAAKAAGKAKRAARPAKYQYKDENGELKTWTGQGRTPAVIK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCHHHHH
KAIEEQGKSLDDFLL
HHHHHHCCCHHHHCC
>Mature Secondary Structure 
SEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESQSQAEIEERARKLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLIADGIDPNELLQASAAAKAAGKAKRAARPAKYQYKDENGELKTWTGQGRTPAVIK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCHHHHH
KAIEEQGKSLDDFLL
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2494066 [H]