Click here to switch to the map view.

The map label for this gene is cusR [H]

Identifier: 153952622

GI number: 153952622

Start: 1417348

End: 1418019

Strand: Direct

Name: cusR [H]

Synonym: JJD26997_1603

Alternate gene names: 153952622

Gene position: 1417348-1418019 (Clockwise)

Preceding gene: 153951642

Following gene: 153951285

Centisome position: 76.82

GC content: 31.4

Gene sequence:

>672_bases
ATGAGAATTTTAGTTATAGAAGATGAGATTAGCCTAAATAAAACAATTATAGACAATCTTAATGAATTTGGTTATCAAAC
CGATTCTTCTGAAAATTTTAAAGATGGAGAATACTTTATCGGCATTAGACATTATGATTTAGTTTTAGCAAACTGGACTT
TACCTGATGGAGATGGAGCAGAACTTGTTAACACTGTTAAGCATAAATCTCCAAGAACTTCAGTTATGATTATATCTTCA
AAAACAGATAAAGAAACAGAAATCAAAGCTTTGAAAGCTGGAGCTGATGATTTTGTTAAAAAACCTTTAGATTTTGATAT
TCTACTCGCAAGAATTGAAGCAAGACTAAGACTTGGCGGAACCAATGTTATTAAAATTGAAAACTTAGTTATTGATCCAG
ATGAGGAAAAAATTACTTATAAAGGTCAAGATATAGAACTTAAAGGAAAACCTTTTGAAGTTTTAACGCACTTAGCAAGA
CATTCAGATCAAATTGTATCCAAAGAACAACTTTTAGATGCCATCTGGGAAGAACCTGAGCTAGTAACTCCAAATGTTAT
CGAAGTAGCTATCAATCAAATTCGTCAAAAAATGGATAAACCATTAAACATATCTACCATAGAAACAGTTCGTCGTAGAG
GATACCGTTTCTGCTTCCCTAAAAAATCTTAA

Upstream 100 bases:

>100_bases
TTAAATTGAAAAAAAAATATTAATTTTTTTTAAAGATATCTAAACATTTACTTAAGCTATGATATAATTCTTTAAATTTT
TCTTAATAAGGATAGAACAA

Downstream 100 bases:

>100_bases
CAATTTTGCACCTCCGGTGCAAAAAATTTATCTTTATTTCTATGTTTTATATTTTATTTAAGTTTGGTTATTGTATAAAC
TAAAATTATTTTTTAAATTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILVIEDEISLNKTIIDNLNEFGYQTDSSENFKDGEYFIGIRHYDLVLANWTLPDGDGAELVNTVKHKSPRTSVMIISS
KTDKETEIKALKAGADDFVKKPLDFDILLARIEARLRLGGTNVIKIENLVIDPDEEKITYKGQDIELKGKPFEVLTHLAR
HSDQIVSKEQLLDAIWEEPELVTPNVIEVAINQIRQKMDKPLNISTIETVRRRGYRFCFPKKS

Sequences:

>Translated_223_residues
MRILVIEDEISLNKTIIDNLNEFGYQTDSSENFKDGEYFIGIRHYDLVLANWTLPDGDGAELVNTVKHKSPRTSVMIISS
KTDKETEIKALKAGADDFVKKPLDFDILLARIEARLRLGGTNVIKIENLVIDPDEEKITYKGQDIELKGKPFEVLTHLAR
HSDQIVSKEQLLDAIWEEPELVTPNVIEVAINQIRQKMDKPLNISTIETVRRRGYRFCFPKKS
>Mature_223_residues
MRILVIEDEISLNKTIIDNLNEFGYQTDSSENFKDGEYFIGIRHYDLVLANWTLPDGDGAELVNTVKHKSPRTSVMIISS
KTDKETEIKALKAGADDFVKKPLDFDILLARIEARLRLGGTNVIKIENLVIDPDEEKITYKGQDIELKGKPFEVLTHLAR
HSDQIVSKEQLLDAIWEEPELVTPNVIEVAINQIRQKMDKPLNISTIETVRRRGYRFCFPKKS

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=27.8026905829596, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=29.4642857142857, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=25.9090909090909, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=29.3577981651376, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=28.9592760180996, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=25.1121076233184, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=25.6756756756757, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367329, Length=174, Percent_Identity=27.0114942528736, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=25, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=24.2152466367713, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787229, Length=217, Percent_Identity=23.5023041474654, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=32.4561403508772, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25510; Mature: 25510

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVIEDEISLNKTIIDNLNEFGYQTDSSENFKDGEYFIGIRHYDLVLANWTLPDGDGA
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCHH
ELVNTVKHKSPRTSVMIISSKTDKETEIKALKAGADDFVKKPLDFDILLARIEARLRLGG
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHEECC
TNVIKIENLVIDPDEEKITYKGQDIELKGKPFEVLTHLARHSDQIVSKEQLLDAIWEEPE
CCEEEEEEEEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVTPNVIEVAINQIRQKMDKPLNISTIETVRRRGYRFCFPKKS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCC
>Mature Secondary Structure
MRILVIEDEISLNKTIIDNLNEFGYQTDSSENFKDGEYFIGIRHYDLVLANWTLPDGDGA
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCHH
ELVNTVKHKSPRTSVMIISSKTDKETEIKALKAGADDFVKKPLDFDILLARIEARLRLGG
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHEECC
TNVIKIENLVIDPDEEKITYKGQDIELKGKPFEVLTHLARHSDQIVSKEQLLDAIWEEPE
CCEEEEEEEEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVTPNVIEVAINQIRQKMDKPLNISTIETVRRRGYRFCFPKKS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]