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The map label for this gene is hldE [H]

Identifier: 153952428

GI number: 153952428

Start: 520381

End: 521766

Strand: Direct

Name: hldE [H]

Synonym: JJD26997_0578

Alternate gene names: 153952428

Gene position: 520381-521766 (Clockwise)

Preceding gene: 153951617

Following gene: 153951000

Centisome position: 28.2

GC content: 34.27

Gene sequence:

>1386_bases
ATGCTTGAGTTTTTAAGCCAGCAAAAACCTAAAATTTTAATTATAGGGGATTTTATGGTGGATAATTACACTTGGTGTGA
TTGTTCGCGTATCAGTCCTGAAGCCCCTGTTTTGGTAGCTAAAACTCTTAAAGAAGATAAAAGATTAGGCGGGGCTGCGA
ATGTTTATGCAAATTTAAAAAGTTTAGGTGCTGATGTTTTTGCACTTGGTGTTGTGGGTGATGATGAGAGTGGGAAATTT
TTACAAGAAAATTTAAAAGGAGAATTTTTGATCCAAAAAGGACGCAAAACCCCTTTTAAAAACCGCATTATGGCACACAA
TCAGCAGGTTTTAAGACTAGATGAAGAAGATACAAGTGAGATTTTGCTTGAAAATGAGCTTATTGCTTTGTTTGATGAAA
AGATTAAAGATTTTAAGGCTGTGGTTTTAAGTGACTATGCTAAGGGTATTTTAACGCCCAAGGTTTGCAAAGCTTTGATA
AAAAAAGCTAAGGCTTTAAATATCCCTGTTTTAGTTGATCCTAAAGGCAGTGATTTTAGTAAATATAGCGGTGCAACCTT
ACTTACGCCTAATAAAAAAGAAGCTTTAGAGGCTTTGAAATTTGAAAATTTAGAGGGTGAAAATTTAGAAAAAGGGATTA
AAAAATTAAAAGAAGATTTTGCTTTGCGTTATTCTATCATCACTCTTTCAGAAGCGGGGATTGCACTTTTTGATAAGAGT
TTAAAAATCGCTCCTGCTAAAGCCTTAGAGGTTTATGATGTAACAGGAGCTGGCGATAGTGTGATTGCGGTTTTGGCTTT
TTGTCTGGCAAATGGGGTTGAAATTTTTAAAGCTTGCGAACTTGCCAATGAAGCCGCAGCTGTTGTGGTGGGTAAAATAG
GTAGCGTGAGTGTGAGTTTTGATGAGATTAAGAGTTTTAATCGTGTGGATTTTGAGAAAAAAATCAAAAGCAAAGAAGAA
CTTTTAACACTCTTAAAACAAAAGGATAAAAAGATCGTTTTTACAAATGGTTGTTTTGATATAGTGCATTTTGGGCATAT
AAAATACCTTGAAAAAGCTAAAAGATTGGGCGATGTTTTGATTGTGGGTTTAAACTCAGATGCGAGTGTGAAAAAACTCA
AAGGCGAGAGTCGTCCTGTAAATTCAGAGTTTCAAAGAGCTTGTATGTTGGCAGCTTTTTATTTTGTAGATTTTGTAGTG
ATTTTTGATGAAGATACGCCTTTGGAACTTATAAGCTTTTTAAAGCCTGATATTTTGGTTAAAGGAGCTGATTATAAAGA
TAAAATTGTTGTGGGTGCGGATATTGTTTCAAAGGTTGAATTAATCGACTTTGAAGAAGGATTTAGTACAAGCAAGATCA
TAGAAAAAATAAAGGATAAAAAATGA

Upstream 100 bases:

>100_bases
AAACTAGATCAAACTTGGGATTATCAGCCAAAATTTAGTCTTGAAGAGGGGATAAAAGATTATTTAGGCGAGATAAAAAG
ACTTTTCGAAAAGGAAGTAA

Downstream 100 bases:

>100_bases
TAAATTTAGTAGAAAAAGAATGGCAAGAACATCAAAAAATAGCTCAAGCCAGTGAAATTTTAAAAGGACAAATCGCTAAA
GTAGGCGAACTTTTGTGCGA

Product: D,D-heptose 1-phosphate adenosyltransferase/7-phosphate kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDESGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDTSEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKALI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDKS
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANGVEIFKACELANEAAAVVVGKIGSVSVSFDEIKSFNRVDFEKKIKSKEE
LLTLLKQKDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKKLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKIVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK

Sequences:

>Translated_461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDESGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDTSEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKALI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDKS
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANGVEIFKACELANEAAAVVVGKIGSVSVSFDEIKSFNRVDFEKKIKSKEE
LLTLLKQKDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKKLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKIVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK
>Mature_461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDESGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDTSEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKALI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDKS
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANGVEIFKACELANEAAAVVVGKIGSVSVSFDEIKSFNRVDFEKKIKSKEE
LLTLLKQKDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKKLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKIVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=470, Percent_Identity=43.1914893617021, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI193203447, Length=82, Percent_Identity=41.4634146341463, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509873, Length=82, Percent_Identity=41.4634146341463, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921220, Length=137, Percent_Identity=37.956204379562, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550973, Length=137, Percent_Identity=37.956204379562, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550974, Length=137, Percent_Identity=37.956204379562, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550975, Length=137, Percent_Identity=37.956204379562, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51042; Mature: 51042

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLK
CCCCCCCCCCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SLGADVFALGVVGDDESGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDTSE
HCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHH
ILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKALIKKAKALNIPVLVDPKGSDFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
KYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDKS
CCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCEEECCC
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANGVEIFKACELANEAAAVVVGKIGSVSVSF
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEEEH
DEIKSFNRVDFEKKIKSKEELLTLLKQKDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVL
HHHHCCCCCCHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEE
IVGLNSDASVKKLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILV
EEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEE
KGADYKDKIVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK
ECCCCCCCEEECHHHHHHEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLK
CCCCCCCCCCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SLGADVFALGVVGDDESGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDTSE
HCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHH
ILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKALIKKAKALNIPVLVDPKGSDFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
KYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDKS
CCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCEEECCC
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANGVEIFKACELANEAAAVVVGKIGSVSVSF
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEEEH
DEIKSFNRVDFEKKIKSKEELLTLLKQKDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVL
HHHHCCCCCCHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEE
IVGLNSDASVKKLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILV
EEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEE
KGADYKDKIVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK
ECCCCCCCEEECHHHHHHEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA