Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 153951886

GI number: 153951886

Start: 1439738

End: 1440151

Strand: Direct

Name: ndk [H]

Synonym: JJD26997_1626

Alternate gene names: 153951886

Gene position: 1439738-1440151 (Clockwise)

Preceding gene: 153951895

Following gene: 153951797

Centisome position: 78.03

GC content: 31.4

Gene sequence:

>414_bases
ATGGAAAAAACTTTATCTATAATTAAACCTGATGCTGTTAAAAAAGGTGTTATAGGAAAAATTTTAGATCGTTTTGAAAG
CAATGGATTAAGAATCGCTGCAATGAAAAAAGTTCAACTTAGTAAAGAACAAGCTGAAAATTTTTATGCTGTTCATAAAG
AAAGACCTTTTTTTAAAGATTTGGTTGAATTTATGATTAGCGGTCCTGTTGTTGTTTCTGTACTAGAAGGGGAAGGTGCT
GTATTGAAAAATAGAGATTTAATGGGGGCGACAAATCCTAAAGAAGCTAAAGCAGGGACAATTAGAGCTGATTTTGCTGA
GAGTATTGATGCTAATGCTGTTCATGGAAGCGATAGCTTAGAAAATGCGAAAATAGAAATTGAATTTTTCTTTAAACCAA
ATGAAATTTACTAA

Upstream 100 bases:

>100_bases
AAAAGCTAGAGATTCCTAGCTTTTTCTTTTAATTTAACTTTCTTTAAACAAATTTAAGTATAATTTTAAGCTTTATTAAA
ATAAGGAGTTATTACAAAAG

Downstream 100 bases:

>100_bases
ATGAAAATCCCTTTTTCTAAGATTAATACAAAGGAATATCCTTTTAAACTTAATCTTGAAAATATGATTTTTGAGGGAAA
TTTAGTAAAAATAAATCCTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIEFFFKPNEIY

Sequences:

>Translated_137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIEFFFKPNEIY
>Mature_137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIEFFFKPNEIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=46.3235294117647, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=46.3235294117647, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=46.3235294117647, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=46.3235294117647, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.1851851851852, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=38.5185185185185, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=36.231884057971, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=36.231884057971, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=37.3134328358209, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI148839372, Length=127, Percent_Identity=37.007874015748, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=58.0882352941177, Blast_Score=165, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=44.4444444444444, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.2222222222222, Blast_Score=124, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=45.1851851851852, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=36.5671641791045, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=31.3868613138686, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15188; Mature: 15188

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHEEEECCCCCHHHH
LVEFMISGPVVVSVLEGEGAVLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCC
ENAKIEIEFFFKPNEIY
CCCEEEEEEEECCCCCC
>Mature Secondary Structure
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHEEEECCCCCHHHH
LVEFMISGPVVVSVLEGEGAVLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCC
ENAKIEIEFFFKPNEIY
CCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA