Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 153951683

GI number: 153951683

Start: 685775

End: 688363

Strand: Direct

Name: gyrA [H]

Synonym: JJD26997_0761

Alternate gene names: 153951683

Gene position: 685775-688363 (Clockwise)

Preceding gene: 153951791

Following gene: 153951840

Centisome position: 37.17

GC content: 33.26

Gene sequence:

>2589_bases
ATGGAGAATATTTTTAGCAAAGATTCTGATATTGAACTTGTAGATATAGAAAATTCTATAAAAAGTAGTTATTTAGACTA
TTCTATGAGTGTTATTATAGGTCGTGCTTTGCCTGATGCAAGAGATGGTTTAAAGCCTGTTCATAGAAGAATTTTATATG
CTATGCAAAATGATGAGGCAAAAAGTAGAACAGATTTTGTCAAATCAGCCCGTATAGTGGGTGCTGTTATAGGTCGTTAT
CACCCGCATGGAGATACAGCAGTTTATGATGCTTTAGTTAGAATGGCTCAAGATTTTTCTATGAGATATCCAAGTATTAC
AGGACAAGGTAACTTTGGATCTATAGATGGCGATAGTGCTGCTGCGATGCGTTATACTGAAGCAAAAATGAGTAAACTTT
CTCATGAGCTTTTAAAAGATATAGATAAAGATACGGTCGATTTTGTTCCAAATTATGATGGTTCAGAAAGTGAACCTGAT
GTTTTACCTTCTAGGGTTCCAAATTTATTATTAAATGGTTCAAGTGGTATAGCTGTAGGTATGGCGACAAATATCCCACC
TCATAGTTTAAATGAGTTGATAGATGGACTTTTATATTTGCTTGATAATAAAGATGTAAGCTTAGAAGAGATTATGCAGT
TTATCAAAGGTCCAGATTTTCCAACAGGTGGAATAATTTATGGTAAAAAAGGCATTATAGAAGCTTATCGCACAGGGCGT
GGTCGTGTGAAAGTGCGCGCTAAAACTCATATTGAAAAAAAGACAAATAAAGATGTTATTGTTATAGATGAGCTTCCTTA
TCAAACCAATAAAGCTAGGCTTATAGAGCAGATTGCAGAGCTTGTTAAAGAAAAGCAAATTGAAGGAATATCTGAAGTAA
GAGATGAGAGCAATAAAGAAGGAATCCGTGTTGTTATAGAGCTTAAACGTGAGGCTATGAGTGAAATTGTTTTAAATAAT
CTATTTAAATCTACCACTATGGAAAGTACTTTTGGTGTGATTATGTTAGCAATTCACAATAAAGAACCTAAAATTTTCTC
TTTGCTAGAACTTTTAAATCTTTTCTTAACCCATAGAAAAACAGTTATTATTAGAAGAACGATTTTTGAACTTCAAAAGG
CAAGAGTAAGAGCTCATATTTTAGAAGGTCTTAAAATTGCACTTGATAATATAGATGAAGTGATTGCTTTAATTAAAAAT
AGTTCCGACAATAATACCGCAAGAGATTCTTTGGTAGCTAAATTTGGTCTTAGTGAACTTCAAGCGAATGCTATTTTAGA
TATGAAACTGGGTCGTTTAACAGGACTTGAAAGAGAAAAAATTGAAAATGAACTTGCAGAATTAATGAAAGAAATTGCAA
GACTTGAAGAAATTTTAAAAAGTGAAACTTTGCTTGAAAATTTAATTCGCGATGAATTAAAAGAAATTAGAAGCAAATTT
GATGTACCACGTATTACTCAAATTGAAGATGATTATGATGATATTGATATTGAAGATTTGATTCCTAATGAAAATATGGT
TGTAACTATCACGCATCGTGGTTATATTAAGCGTGTGCCTAGTAAACAATATGAAAAGCAAAAACGAGGCGGAAAAGGAA
AATTAGCCGTTACGACTTATGATGATGATTTTATAGAAAGTTTCTTTACGGCAAATACACATGATACGCTTATGTTTGTA
ACAGATCGTGGACAGCTTTATTGGCTTAAAGTTTATAAAATTCCTGAAGGCTCAAGAACGGCTAAAGGAAAAGCAGTGGT
AAATCTTATCAATTTACAAGCTGAAGAAAAAATCATGGCTATTATTCCAACCACGGATTTTGACGAGAGTAAATCTTTAT
GTTTCTTTACTAAAAATGGTATTGTAAAGCGTACAAATTTGAGTGAATATCAAAATATCAGAAGTATTGGAGTTAGAGCG
ATCAACTTAAATGAAAATGATGAGTTGGTAACTGCTATTATTGTTCAAAGAGATGAAGATGAAATTTTTGCCAGTGGTGG
TGAAGAAAATTTAGAAAATCAAGAAATTGAAAATTTAGATGATGAAAATCTTGAAAATGAAGAAAGTGCAAGTACACAAG
GTAAAATGCTCTTTGCAGTAACCAAAAAAGGTATGTGTATCAAATTCCCGCTTGTTAAAGTGCGTGAAATCGGCCGTGTA
AGTCGTGGGGTGACAGCTATTAAGTTTAAAGAGAAAAATGACGAATTAGTAGGTGCAGTTGTTATAGAAAATGATGAGCA
AGAAATTTTAAGCGTAAGTGCAAAAGGTATAGGAAAACGCACCAATGCTGGAGAATATAGATTGCAAAGTAGAGGTGGTA
AGGGTGTAATTTGCATGAAGCTTACAGAAAAAACTAAAGATCTTATTAGTGTAGTTATAGTAGATGAAACTATGGATTTG
ATGGCTCTTACAAGTTCAGGCAAGATGATACGTGTTGATATGCAAAGCATTAGAAAAGCAGGGCGTAATACGAGTGGCGT
CATCGTGGTTAATGTGGAAAATGACGAGGTGGTTAGCATCGCTAAGTGTCCTAAAGAGGAAAATGATGAGGATGAGTTAA
GCGATGAAAACTTTGGTTTAGATTTGTAA

Upstream 100 bases:

>100_bases
TTAGAAGAAAATAAAATTTCTGTACTTTTTGCTCTTGTTTTAGCTGATGCAAAAGTTTAATATGCTATAATCAAAACTTT
GAACTAATAGAAGGATTTTT

Downstream 100 bases:

>100_bases
TAAGTTTAAAGTTGGAACGCTTATTGCTTTTTATTTTACTAAATTACAATATTTTGAAGGTGTAAAAATGAAAAAAATTT
ATTTTATGCTAGTAATAGCA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDNKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARVRAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSIGVRA
INLNENDELVTAIIVQRDEDEIFASGGEENLENQEIENLDDENLENEESASTQGKMLFAVTKKGMCIKFPLVKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSVSAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL

Sequences:

>Translated_862_residues
MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDNKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARVRAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSIGVRA
INLNENDELVTAIIVQRDEDEIFASGGEENLENQEIENLDDENLENEESASTQGKMLFAVTKKGMCIKFPLVKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSVSAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL
>Mature_862_residues
MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDNKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARVRAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSIGVRA
INLNENDELVTAIIVQRDEDEIFASGGEENLENQEIENLDDENLENEESASTQGKMLFAVTKKGMCIKFPLVKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSVSAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=344, Percent_Identity=26.1627906976744, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI19913408, Length=309, Percent_Identity=25.2427184466019, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=882, Percent_Identity=47.1655328798186, Blast_Score=799, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=661, Percent_Identity=36.3086232980333, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=274, Percent_Identity=27.7372262773723, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=275, Percent_Identity=27.6363636363636, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=172, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=390, Percent_Identity=24.6153846153846, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136538, Length=355, Percent_Identity=24.7887323943662, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96860; Mature: 96860

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCHHCCHHHHHHHHHHHHCCCCH
KSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
AAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEE
MATNIPPHSLNELIDGLLYLLDNKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
EECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCC
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKE
CEEEEEEEHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCH
TVIIRRTIFELQKARVRAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
QANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
HHHHEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTY
CCCCEEECCCCCCCCCHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHCCCCCCEEEEEC
DDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMA
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCHHEEEEEECCCCCCEEE
IIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSIGVRAINLNENDELVTAIIVQRDED
EECCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHCEEEEECCCCCCEEEEEEEECCCC
EIFASGGEENLENQEIENLDDENLENEESASTQGKMLFAVTKKGMCIKFPLVKVREIGRV
HHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHH
SRGVTAIKFKEKNDELVGAVVIENDEQEILSVSAKGIGKRTNAGEYRLQSRGGKGVICMK
HCCEEEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
LTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSI
ECHHHHHHEEEEEECCCCCEEEEECCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCEEEH
AKCPKEENDEDELSDENFGLDL
HHCCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCHHCCHHHHHHHHHHHHCCCCH
KSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
AAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEE
MATNIPPHSLNELIDGLLYLLDNKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
EECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCC
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKE
CEEEEEEEHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCH
TVIIRRTIFELQKARVRAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
QANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
HHHHEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTY
CCCCEEECCCCCCCCCHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHCCCCCCEEEEEC
DDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMA
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCHHEEEEEECCCCCCEEE
IIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSIGVRAINLNENDELVTAIIVQRDED
EECCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHCEEEEECCCCCCEEEEEEEECCCC
EIFASGGEENLENQEIENLDDENLENEESASTQGKMLFAVTKKGMCIKFPLVKVREIGRV
HHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHH
SRGVTAIKFKEKNDELVGAVVIENDEQEILSVSAKGIGKRTNAGEYRLQSRGGKGVICMK
HCCEEEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
LTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSI
ECHHHHHHEEEEEECCCCCEEEEECCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCEEEH
AKCPKEENDEDELSDENFGLDL
HHCCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8384814; 10688204 [H]