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The map label for this gene is pyrG [H]

Identifier: 153951536

GI number: 153951536

Start: 34406

End: 36037

Strand: Direct

Name: pyrG [H]

Synonym: JJD26997_0029

Alternate gene names: 153951536

Gene position: 34406-36037 (Clockwise)

Preceding gene: 153952334

Following gene: 153952383

Centisome position: 1.86

GC content: 34.99

Gene sequence:

>1632_bases
ATGAAACAAACAAAATATATTTTTGTAACAGGTGGAGTTTTAAGTTCTTTAGGCAAAGGAATAGCCGCTGCTTCTATTGC
AACACTTTTAAAAAATTCAGGACTTAAAGCGAGTATTTTAAAAGCTGATCCTTATATCAATGTCGATCCAGGCACTATGA
GTCCTTTTGAACATGGAGAAGTTTTTGTAACCGATGATGGAGCAGAAACGGATCTTGATTTGGGGCATTATGAGCGTTTT
TTGGATGAGAGTTTATCTCAAGATAATAATTTCACTACAGGACGTGTTTATCAAAGTGTGATTGAAAAAGAAAGGCGTGG
AGAATATCTTGGTAAAACCATTCAAGTTATCCCGCATATAGTAGGAGAAATCAAAGATCGCATTAAAAAAGCAGGAGAGG
GCAAAGATATACTCATCGTTGAAATAGGCGGAACTGTTGGGGATATAGAAGGCTTGCCTTTTTTAGAAGCCATTCGTGCT
TTGCGTTTGGAAGTGGGTAAAAATAATGCTATGAATATTCATCTTACTCTAGTACCTTTTATCAAGGCTGCAGGGGAGTT
AAAAACAAAGCCAACTCAACATAGTGTAGGCGAGTTAAGACGCATAGGTATTAGTCCTGATATGATTATTTGTCGTAGTG
AAAAAGCTCTTGATAGGGATTTAAAAGATAAAATCGCTATTTCTTGTGGGGTGGAAAAAAATTGCGTGATAGAAAGTGTT
GATGCGGCTAGTATTTATCAAATTCCACTTAATTTTTTAAAGCAAGATATTTTAAATCCTATTGCTGAAATTTTGGATTT
GAAAAATTTAAAACCTAATATGGAAAATTGGGACTCTTTGGTAAAAAGAGTTATAGCTCCAAGCAATGAAGTTAAAATCG
CTTTTGTGGGTAAATATGTGGATTTAAAAGAAAGCTATAAAAGCCTTACTGAAGCTATTATACACGCAGGTGCAGCCCTA
GATACTAAAGTGGAGTTAAAATGGGTAGATAGTGAAAAACTTGAAAATATGGAAAGTGCTGAAGTATTTAAAGATGTGAG
TGGAATTTTAGTTGCGGGGGGATTTGGATATCGTGGTGTAGAAGGTAAGATAAAAGCTATTCAATACGCCAGAGAAAATA
AAATTCCTTTTTTAGGAATTTGTTTGGGTATGCAGCTTGCTTTGGTGGAATTTGCTAGAAATGTATTAAAACTTAAAGAT
GCAAATTCAAGTGAATTTGATGAGAAATGTGAAAATCCTGTGGTTTATTTGATTGATGAATTTATGGATACAAATGGAGA
AAAACAAATTCGTACTGCAAAAACTCCTTTAGGCGGAACTATGCGTTTAGGGGCTTATAAATGTGATATCAAGGAAAAAT
CCCTTTTGGCTAAGGTTTATAATGAAGCAAAGAGTGTCAAAGAACGCCATCGCCATCGCTATGAAGCAAATCCAAAATAT
AGAGTAGATTTTGAAAAACACGGTTTGATTGTAAGTGGTGAAAGCAAAGGATTGATCGAAGCAGTTGAGCTTAACTGTCA
TCCTTTTTTCTTGGCTGTGCAGTTTCATCCAGAATTTACATCAAGACTTGAGCATGTTAATCCTGTGATTTGCGGTTTTA
TCAAGGCAGCTATAAACTATGAAGATAATTAA

Upstream 100 bases:

>100_bases
AAAATATTTTTTGTAATTCTTGCATTTTTTACTTAAAATTCTAATGAAATAAAAAGTTTTATCAAGCTATAATTAGATAA
AAAAATAAGGCTTATTATCA

Downstream 100 bases:

>100_bases
TAAAAATGAAATTAAAAAAATTTTGGCTTCACGCTTTGAAAAAGATTTGCATACCAAACTTTGTGATCTGCCTTTGCCAT
GCTGTTTAAAGGATGCATAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKASILKADPYINVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERF
LDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHIVGEIKDRIKKAGEGKDILIVEIGGTVGDIEGLPFLEAIRA
LRLEVGKNNAMNIHLTLVPFIKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIAISCGVEKNCVIESV
DAASIYQIPLNFLKQDILNPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYVDLKESYKSLTEAIIHAGAAL
DTKVELKWVDSEKLENMESAEVFKDVSGILVAGGFGYRGVEGKIKAIQYARENKIPFLGICLGMQLALVEFARNVLKLKD
ANSSEFDEKCENPVVYLIDEFMDTNGEKQIRTAKTPLGGTMRLGAYKCDIKEKSLLAKVYNEAKSVKERHRHRYEANPKY
RVDFEKHGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHVNPVICGFIKAAINYEDN

Sequences:

>Translated_543_residues
MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKASILKADPYINVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERF
LDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHIVGEIKDRIKKAGEGKDILIVEIGGTVGDIEGLPFLEAIRA
LRLEVGKNNAMNIHLTLVPFIKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIAISCGVEKNCVIESV
DAASIYQIPLNFLKQDILNPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYVDLKESYKSLTEAIIHAGAAL
DTKVELKWVDSEKLENMESAEVFKDVSGILVAGGFGYRGVEGKIKAIQYARENKIPFLGICLGMQLALVEFARNVLKLKD
ANSSEFDEKCENPVVYLIDEFMDTNGEKQIRTAKTPLGGTMRLGAYKCDIKEKSLLAKVYNEAKSVKERHRHRYEANPKY
RVDFEKHGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHVNPVICGFIKAAINYEDN
>Mature_543_residues
MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKASILKADPYINVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERF
LDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHIVGEIKDRIKKAGEGKDILIVEIGGTVGDIEGLPFLEAIRA
LRLEVGKNNAMNIHLTLVPFIKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIAISCGVEKNCVIESV
DAASIYQIPLNFLKQDILNPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYVDLKESYKSLTEAIIHAGAAL
DTKVELKWVDSEKLENMESAEVFKDVSGILVAGGFGYRGVEGKIKAIQYARENKIPFLGICLGMQLALVEFARNVLKLKD
ANSSEFDEKCENPVVYLIDEFMDTNGEKQIRTAKTPLGGTMRLGAYKCDIKEKSLLAKVYNEAKSVKERHRHRYEANPKY
RVDFEKHGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHVNPVICGFIKAAINYEDN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=558, Percent_Identity=45.8781362007168, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI28559085, Length=560, Percent_Identity=45.3571428571429, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI28559083, Length=560, Percent_Identity=45.3571428571429, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI221316689, Length=560, Percent_Identity=45.3571428571429, Blast_Score=476, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=540, Percent_Identity=52.962962962963, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=611, Percent_Identity=40.0981996726678, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=572, Percent_Identity=43.8811188811189, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=42.6315789473684, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=47.0483005366726, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=45.4365079365079, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60302; Mature: 60302

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKASILKADPYINVDPGTMSPFEHGE
CCCCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCE
VFVTDDGAETDLDLGHYERFLDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHI
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEIKDRIKKAGEGKDILIVEIGGTVGDIEGLPFLEAIRALRLEVGKNNAMNIHLTLVPF
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEHH
IKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIAISCGVEKNCVIESV
HHHCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHCCCHHHHEEEECCCCCCCEEECC
DAASIYQIPLNFLKQDILNPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCH
DLKESYKSLTEAIIHAGAALDTKVELKWVDSEKLENMESAEVFKDVSGILVAGGFGYRGV
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCEEEECCCCCCCC
EGKIKAIQYARENKIPFLGICLGMQLALVEFARNVLKLKDANSSEFDEKCENPVVYLIDE
CCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEHH
FMDTNGEKQIRTAKTPLGGTMRLGAYKCDIKEKSLLAKVYNEAKSVKERHRHRYEANPKY
HHCCCCCCEEEECCCCCCCCEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
RVDFEKHGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHVNPVICGFIKAAINY
EEEHHHCCEEEECCCCCCEEEEEECCCEEEEEEEECCHHHHHHHHCCHHHHHHHHHHHCC
EDN
CCC
>Mature Secondary Structure
MKQTKYIFVTGGVLSSLGKGIAAASIATLLKNSGLKASILKADPYINVDPGTMSPFEHGE
CCCCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCE
VFVTDDGAETDLDLGHYERFLDESLSQDNNFTTGRVYQSVIEKERRGEYLGKTIQVIPHI
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEIKDRIKKAGEGKDILIVEIGGTVGDIEGLPFLEAIRALRLEVGKNNAMNIHLTLVPF
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEHH
IKAAGELKTKPTQHSVGELRRIGISPDMIICRSEKALDRDLKDKIAISCGVEKNCVIESV
HHHCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHCCCHHHHEEEECCCCCCCEEECC
DAASIYQIPLNFLKQDILNPIAEILDLKNLKPNMENWDSLVKRVIAPSNEVKIAFVGKYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCH
DLKESYKSLTEAIIHAGAALDTKVELKWVDSEKLENMESAEVFKDVSGILVAGGFGYRGV
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCEEEECCCCCCCC
EGKIKAIQYARENKIPFLGICLGMQLALVEFARNVLKLKDANSSEFDEKCENPVVYLIDE
CCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEHH
FMDTNGEKQIRTAKTPLGGTMRLGAYKCDIKEKSLLAKVYNEAKSVKERHRHRYEANPKY
HHCCCCCCEEEECCCCCCCCEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
RVDFEKHGLIVSGESKGLIEAVELNCHPFFLAVQFHPEFTSRLEHVNPVICGFIKAAINY
EEEHHHCCEEEECCCCCCEEEEEECCCEEEEEEEECCHHHHHHHHCCHHHHHHHHHHHCC
EDN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA