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The map label for this gene is thrB [H]

Identifier: 153951476

GI number: 153951476

Start: 141981

End: 142859

Strand: Direct

Name: thrB [H]

Synonym: JJD26997_0147

Alternate gene names: 153951476

Gene position: 141981-142859 (Clockwise)

Preceding gene: 153952600

Following gene: 153952023

Centisome position: 7.7

GC content: 31.74

Gene sequence:

>879_bases
TTGAAAATTTTAGTTCCCGCTACGAGTGCGAATTTAGGGCCAGGTTTTGATTGTTTAGGACTTAGTTTAAAGCTTTTTAA
TGAAACTCAAATCCAAAAATCAGGTGTTTTTAGCATTAGTATTGGAGGTGAGGGCAGTGATAATATTTTTCTTAAAAAAA
ACAATATATTTGTAAATATTTTTTATGAAATTTATGAAAAACTAAGCGGAAAAAAAGATAATTTTCGTTTTATTTTTCAA
AATAACATTCCTCTTTCAAGAGGGTTAGGAAGCTCTTCAGCTGTGATTGTTGGAGCTATTGCCAGTGCTTATTATATGAG
TGGATTTAAGGTAGAAAAAAAACGTATTTTAGATGAAGCTTTAATTTATGAAAACCATCCAGATAATATCGCTCCAGCCA
CCCTTGGTGGTTTTGTGTGTTCTTTGGTTGAAAAAAATAAAGTTTATAGTATCAAAAAAGAGATCGATAAAGATTTAGCT
GCTGTGGTTGTGATCCCAAATTTGGCAATGAGCACGGAACAATCACGTCAAGCTTTGGCCAAAAATTTAAGTTTTAATGA
TGCGGTTTTCAACCTTTCCCATGCTTCATTTTTAACCGCTTGTTTTTTGGAGAAAAAATATGAATTTTTAAAATTTGCAA
GTCAAGATAAGCTCCATGAAATCAATCGTATGAAAAACTTACCCGAGCTTTTTGAAGTGCAAAAATTTGCCTTAGAAAAT
AAAGCTTTAATGAGCACGCTTTCAGGTTCGGGATCGAGCTTTTTTTCTTTAGCTTTTAAAGATGATGCTTTGGCTTTAGC
GAAGAAAATGCAAACAAAATTTAAAGATTTTAGTGTGCAATATTTAGAATTTGATGATAATGGCTTTGAAATTTGCTAA

Upstream 100 bases:

>100_bases
ATATCCCAGCAGAGTTTTTTTTACCAAAAAATTTACAAGAGCTTAAACTAAATAATGATAATCTTCCCTTTTATTTTTTA
GATGCAATTTAGGATGAAAT

Downstream 100 bases:

>100_bases
AAAATATAAAAAAAAGATATAATTTTGAAAAAACATATACCAATTAGAATGTGCATAGTGTGTAAAAACCGCTTTGATCA
AAATGTGTTATTTAGATTTA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNIFYEIYEKLSGKKDNFRFIFQ
NNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKKRILDEALIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLA
AVVVIPNLAMSTEQSRQALAKNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQKFALEN
KALMSTLSGSGSSFFSLAFKDDALALAKKMQTKFKDFSVQYLEFDDNGFEIC

Sequences:

>Translated_292_residues
MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNIFYEIYEKLSGKKDNFRFIFQ
NNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKKRILDEALIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLA
AVVVIPNLAMSTEQSRQALAKNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQKFALEN
KALMSTLSGSGSSFFSLAFKDDALALAKKMQTKFKDFSVQYLEFDDNGFEIC
>Mature_292_residues
MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNIFYEIYEKLSGKKDNFRFIFQ
NNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKKRILDEALIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLA
AVVVIPNLAMSTEQSRQALAKNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQKFALEN
KALMSTLSGSGSSFFSLAFKDDALALAKKMQTKFKDFSVQYLEFDDNGFEIC

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=280, Percent_Identity=27.1428571428571, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321814, Length=320, Percent_Identity=28.4375, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32503; Mature: 32503

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNI
CEEEEECCCCCCCCCCHHHCCEEEECCCHHHHHCCEEEEEECCCCCCCEEEEECCEEEEE
FYEIYEKLSGKKDNFRFIFQNNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKKRILDEA
HHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLAAVVVIPNLAMSTEQSRQALA
HHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
KNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQKFALEN
HCCCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
KALMSTLSGSGSSFFSLAFKDDALALAKKMQTKFKDFSVQYLEFDDNGFEIC
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNI
CEEEEECCCCCCCCCCHHHCCEEEECCCHHHHHCCEEEEEECCCCCCCEEEEECCEEEEE
FYEIYEKLSGKKDNFRFIFQNNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKKRILDEA
HHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLAAVVVIPNLAMSTEQSRQALA
HHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
KNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQKFALEN
HCCCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
KALMSTLSGSGSSFFSLAFKDDALALAKKMQTKFKDFSVQYLEFDDNGFEIC
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA