| Definition | Campylobacter jejuni subsp. doylei 269.97, complete genome. |
|---|---|
| Accession | NC_009707 |
| Length | 1,845,106 |
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The map label for this gene is gyrB [H]
Identifier: 153951349
GI number: 153951349
Start: 2579
End: 4888
Strand: Direct
Name: gyrB [H]
Synonym: JJD26997_0003
Alternate gene names: 153951349
Gene position: 2579-4888 (Clockwise)
Preceding gene: 153952198
Following gene: 153952179
Centisome position: 0.14
GC content: 33.12
Gene sequence:
>2310_bases ATGCAAGAAAATTACGGTGCGAGTAATATTAAAGTCCTAAAAGGCTTAGAAGCTGTTAGAAAACGCCCAGGTATGTATAT AGGAGATACAAATATAGGTGGACTTCATCACATGATTTATGAAGTTGTGGATAATTCTATCGATGAAGCTATGGCAGGAC ATTGTGATACTATAGATGTAGAAATCACTACTGAAGGAAGCTGTATAGTTAGTGATAATGGTCGTGGTATTCCTGTTGAT ATGCACCCAACTGAAAATATGCCAACTTTAACTGTTGTTTTAACTGTCCTTCATGCAGGGGGAAAATTCGATAAAGATAC TTATAAAGTTTCAGGCGGTTTGCACGGTGTTGGGGTTTCAGTTGTAAATGCACTTTCTAAAAAACTTGTAGCTACAGTTG AAAGAAATAAAGAAATTTATCGCCAAGAATTTTCAGAAGGTAAAGTTATCAGTGAATTTGGTGTGATAGGAAAAAGCAAA AAAACAGGGACAACTATAGAATTTTGGCCTGATGATCAAATTTTTGAAGTGACTGAATTTGATTATGAAATTTTAGCTAA AAGATTTCGCGAACTTGCATACTTAAATCCAAAAATTACTATAAATTTTAAAGATAACCGTGTAGGCAAACATGAAAGTT TTCATTTTGAAGGTGGAATTTCTCAGTTTGTTACAGACTTAAATAAAAAAGAAGCTTTAACTAAAGCAATTTTCTTTAGC GTAGATGAAGAAGATGTGAATGTTGAAGTAGCTTTGCTTTACAATGATACTTATAGTGAAAATTTACTTTCTTTTGTAAA TAATATCAAAACCCCAGATGGTGGAACACACGAAGCTGGTTTTAGAATGGGCTTAACTCGTGTGATAAGTAACTATATAG AAGCAAATGCAAGTGCTAGAGAAAAGGATAATAAAATCACGGGCGAAGATGTGCGTGAAGGTTTGATCGCTGTTGTGAGT GTAAAGGTGCCTGAACCACAATTTGAAGGACAAACCAAAGGAAAACTTGGTTCAACTTATGTACGTCCTATAGTTTCAAA AGCAAGCTTTGAGTATTTGACTAAATATTTTGAAGAAAATCCTGTCGAAGCTAAAGCTATAATGAACAAAGCCTTAATGG CAGCACGTGGTAGAGAAGCAGCAAAAAAAGCTAGAGAATTAACGCGTAAAAAAGAAAGTTTAAGTGTAGGAACTTTACCA GGGAAATTAGCTGATTGTCAAAGTAAAGATCCAAGTGAAAGTGAAATTTATCTTGTGGAAGGGGATTCTGCAGGAGGTTC TGCAAAACAAGGTAGAGAAAGATCTTTCCAAGCTATATTGCCTTTGCGTGGTAAAATTTTAAATGTTGAAAAAGCAAGAC TGGATAAAATTTTAAAATCTGAGCAAATTCAAAATATGATTACCGCTTTTGGTTGTGGTATAGGTGAAGATTTTGATCTT TCAAAACTCAGATATCATAAAATCATCATCATGACAGATGCGGATGTTGATGGATCGCATATACAAACCTTGCTTTTAAC TTTCTTTTTCCGTTTTATGAATGAACTTGTGGCAAATGGACATATTTATCTAGCACAACCGCCTTTATATCTTTATAAAA AAGCTAAAAAGCAAATTTATTTAAAAGATGAAAAAGCTTTGAGCGAATATCTGATAGAAACGGGAATAGAAGGTTTAAAC TATGAAGGTATAGGAATGAATGATTTAAAAGATTATTTAAAAATCGTTGCAGCTTATCGTGCGATTTTAAAAGATCTTGA AAAGCGTTTTAATGTGATTTCTGTGATACGCTATATGATAGAAAATTCAAATTTAGTTAAAGGAAATAATGAAGAATTAT TTAGTGTAATCAAACAATTTTTAGAAACACAAGGACACAATATCTTAAATCATTATATCAACGAAAATGAAATTCGAGCT TTCGTTCAAACTCAAAATGGCTTAGAAGAACTTGTGATCAATGAAGAACTTTTCACTCATCCACTCTATGAAGAAGCAAG TTATATTTTTGATAAGATTAAAGATAGAGGCTTGGAATTTGATAAAGATATTTTAGAAGTTCTTGAAGATGTTGAAACCA ATGCTAAAAAAGGTGCTACTATACAACGCTATAAAGGTTTAGGGGAAATGAATCCTGAGCAACTTTGGGAAACCACAATG GATCCAAGCGTAAGAAGACTTTTAAAAATCACTATTGAAGATGCACAAAGTGCAAATGATACCTTTAATCTCTTTATGGG TGATGAGGTCGAACCAAGACGCGATTATATCCAAGTACACGCTAAAGATGTAAAACATTTGGATGTGTAA
Upstream 100 bases:
>100_bases AGTGAACCTAATTCAGCATTTATAGTCAAATCTCAGGGACTATCAATGATTATCATGCCTATGATTTTATAACAAAAACA AGTAAAAATAAAGGAAAAAT
Downstream 100 bases:
>100_bases AAATTTTATTTAGTATTAAAGGGGTTTTGTGTAACAAATCAACCCCTTTAATGTGTTACAGCTTCACTTACTCCTACACC GCTTTGAGCTCTAAAATCTT
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 769; Mature: 769
Protein sequence:
>769_residues MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDVEITTEGSCIVSDNGRGIPVD MHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVSVVNALSKKLVATVERNKEIYRQEFSEGKVISEFGVIGKSK KTGTTIEFWPDDQIFEVTEFDYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFS VDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAREKDNKITGEDVREGLIAVVS VKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEENPVEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLP GKLADCQSKDPSESEIYLVEGDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDL SKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIYLKDEKALSEYLIETGIEGLN YEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMIENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRA FVQTQNGLEELVINEELFTHPLYEEASYIFDKIKDRGLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTM DPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQVHAKDVKHLDV
Sequences:
>Translated_769_residues MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDVEITTEGSCIVSDNGRGIPVD MHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVSVVNALSKKLVATVERNKEIYRQEFSEGKVISEFGVIGKSK KTGTTIEFWPDDQIFEVTEFDYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFS VDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAREKDNKITGEDVREGLIAVVS VKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEENPVEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLP GKLADCQSKDPSESEIYLVEGDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDL SKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIYLKDEKALSEYLIETGIEGLN YEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMIENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRA FVQTQNGLEELVINEELFTHPLYEEASYIFDKIKDRGLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTM DPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQVHAKDVKHLDV >Mature_769_residues MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDVEITTEGSCIVSDNGRGIPVD MHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVSVVNALSKKLVATVERNKEIYRQEFSEGKVISEFGVIGKSK KTGTTIEFWPDDQIFEVTEFDYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFS VDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAREKDNKITGEDVREGLIAVVS VKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEENPVEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLP GKLADCQSKDPSESEIYLVEGDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDL SKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIYLKDEKALSEYLIETGIEGLN YEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMIENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRA FVQTQNGLEELVINEELFTHPLYEEASYIFDKIKDRGLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTM DPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQVHAKDVKHLDV
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=574, Percent_Identity=26.4808362369338, Blast_Score=131, Evalue=2e-30, Organism=Homo sapiens, GI19913406, Length=562, Percent_Identity=27.4021352313167, Blast_Score=122, Evalue=1e-27, Organism=Escherichia coli, GI48994957, Length=816, Percent_Identity=48.406862745098, Blast_Score=710, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=547, Percent_Identity=40.5850091407678, Blast_Score=394, Evalue=1e-110, Organism=Caenorhabditis elegans, GI212645845, Length=503, Percent_Identity=26.6401590457256, Blast_Score=126, Evalue=4e-29, Organism=Caenorhabditis elegans, GI17535065, Length=553, Percent_Identity=24.4122965641953, Blast_Score=123, Evalue=4e-28, Organism=Saccharomyces cerevisiae, GI6324241, Length=552, Percent_Identity=28.804347826087, Blast_Score=128, Evalue=4e-30, Organism=Drosophila melanogaster, GI17136538, Length=511, Percent_Identity=28.1800391389432, Blast_Score=137, Evalue=3e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 - InterPro: IPR006171 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 86705; Mature: 86705
Theoretical pI: Translated: 5.31; Mature: 5.31
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDV CCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE EITTEGSCIVSDNGRGIPVDMHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVS EEEECCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH VVNALSKKLVATVERNKEIYRQEFSEGKVISEFGVIGKSKKTGTTIEFWPDDQIFEVTEF HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCEEEECCCCCEEEHHHC DYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFS CHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEE VDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAR ECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH EKDNKITGEDVREGLIAVVSVKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEEN HCCCCCCHHHHHCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC PVEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLPGKLADCQSKDPSESEIYLVE CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE GDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDL CCCCCCCCCCCHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC SKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIY CCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHEE LKDEKALSEYLIETGIEGLNYEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMI ECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRAFVQTQNGLEELVINEELFTH CCCCEECCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHCHHHHHC PLYEEASYIFDKIKDRGLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTM CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCC DPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQVHAKDVKHLDV CHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC >Mature Secondary Structure MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDV CCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE EITTEGSCIVSDNGRGIPVDMHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVS EEEECCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH VVNALSKKLVATVERNKEIYRQEFSEGKVISEFGVIGKSKKTGTTIEFWPDDQIFEVTEF HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCEEEECCCCCEEEHHHC DYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFS CHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEE VDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAR ECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH EKDNKITGEDVREGLIAVVSVKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEEN HCCCCCCHHHHHCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC PVEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLPGKLADCQSKDPSESEIYLVE CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE GDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDL CCCCCCCCCCCHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC SKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIY CCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHEE LKDEKALSEYLIETGIEGLNYEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMI ECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRAFVQTQNGLEELVINEELFTH CCCCEECCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHCHHHHHC PLYEEASYIFDKIKDRGLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTM CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCC DPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQVHAKDVKHLDV CHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10688204 [H]