Click here to switch to the map view.

The map label for this gene is mhpE [C]

Identifier: 153951234

GI number: 153951234

Start: 657232

End: 658224

Strand: Direct

Name: mhpE [C]

Synonym: JJD26997_0727

Alternate gene names: 153951234

Gene position: 657232-658224 (Clockwise)

Preceding gene: 153952102

Following gene: 153952142

Centisome position: 35.62

GC content: 30.92

Gene sequence:

>993_bases
ATGAATATACAAATTTTAGATTGCACTCTAAGAGATGGTTCTCACATTAATAATGGTAAATTTGGCAAAGAAAAAATTAG
GCAAATTATAACAGGACTTATTGAGGCAAATATTGATATTATCGAGGTTGGATTATTGCAAAATCATCAATGTGGAGTTG
ATTTTAGCATTTTTAATTCTATCGATTTTGTTGATCAATGTTTAAGTACCATTGAAAAGAAAAATTCCAAATTTTCTTTA
ATGCTAAGAACAGATCGCGTTGATTTTAATAAGCTCGCCAAAAGCCCCAAGGTAGATTTCATAAGAATAGCCCTCTACCA
AGAACATCTTAACGACATCAAACGCTATGGCGAAAAAGCCAAAGAGCTGGGCTATGAAATTATTTTTAATCCCATAGCCA
TAACAAAATATAGCCCAAATGAAATTCAATTTTTAATCAAAACTCTTGAAGAACTAAAGCCTTATGGAATTTCCCTAGTG
GATACTTTTGGCTCTTTTACTCTAAATGAATTTGAAAAAGTATTAAAAATTTTTGACGAAAATTTAAGCCCAAACATTAC
ACTTGGCATTCATCTACACCAAAACTTAAACCTAGCTCCTAGTTTAGCCGCAAAAGCGACAAAGCTCATCATAAACCGCG
ATCTAATCATTGATAGTTCCCTTAGCGGTATGGGTAGAGTTCCGGGCAATTTACAAAGTGAGCTTTTTGCAAATTATCTC
AATCAAAATTTTAATCATCAATATAACATAGAAAAATTACTCTCCCTTACCGCTTTAATTGAAGAATTTGAAATACTTAA
TCGCTGGGGATATAATCCTATTTATATGTATTCAGCCTCTTTAAACATCGATAGAACCTATCCTGAATTTTTTGAAAAAA
TGGGCTTTTGCATTGAAAATAATTTAAATTTACAAAAAATTTGTAAAGAAAAAGGAATAGGGAGCAAATTTAACGAAGAG
GAAGCACAAAAAATCATTAATTCTTATAATTAA

Upstream 100 bases:

>100_bases
TTCCCTTTAAGGAACTAATCCACAAAAAAGATTCTTTTGAGATTAAAGATAAAGAAAGTTTTATATTTTTCAAAAATATG
TTAGATAAAAAGGAGAGAAA

Downstream 100 bases:

>100_bases
GTAAATTAGGATATTTCAATAAAATATCCTAATTTCGCCTCTCAATCCCCGTGCGTTGGTAAATGCTCAGGCTCGATTTC
GTTATTTTTGATAAATTCCT

Product: hypothetical protein

Products: NA

Alternate protein names: HOA 3; 4-hydroxy-2-keto-pentanoic acid aldolase 3; 4-hydroxy-2-oxopentanoate aldolase 3 [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCGVDFSIFNSIDFVDQCLSTIEKKNSKFSL
MLRTDRVDFNKLAKSPKVDFIRIALYQEHLNDIKRYGEKAKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLV
DTFGSFTLNEFEKVLKIFDENLSPNITLGIHLHQNLNLAPSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANYL
NQNFNHQYNIEKLLSLTALIEEFEILNRWGYNPIYMYSASLNIDRTYPEFFEKMGFCIENNLNLQKICKEKGIGSKFNEE
EAQKIINSYN

Sequences:

>Translated_330_residues
MNIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCGVDFSIFNSIDFVDQCLSTIEKKNSKFSL
MLRTDRVDFNKLAKSPKVDFIRIALYQEHLNDIKRYGEKAKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLV
DTFGSFTLNEFEKVLKIFDENLSPNITLGIHLHQNLNLAPSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANYL
NQNFNHQYNIEKLLSLTALIEEFEILNRWGYNPIYMYSASLNIDRTYPEFFEKMGFCIENNLNLQKICKEKGIGSKFNEE
EAQKIINSYN
>Mature_330_residues
MNIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCGVDFSIFNSIDFVDQCLSTIEKKNSKFSL
MLRTDRVDFNKLAKSPKVDFIRIALYQEHLNDIKRYGEKAKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLV
DTFGSFTLNEFEKVLKIFDENLSPNITLGIHLHQNLNLAPSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANYL
NQNFNHQYNIEKLLSLTALIEEFEILNRWGYNPIYMYSASLNIDRTYPEFFEKMGFCIENNLNLQKICKEKGIGSKFNEE
EAQKIINSYN

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=222, Percent_Identity=23.8738738738739, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 37882; Mature: 37882

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCGVDFSIFNS
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
IDFVDQCLSTIEKKNSKFSLMLRTDRVDFNKLAKSPKVDFIRIALYQEHLNDIKRYGEKA
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
KELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLVDTFGSFTLNEFEKVLKIFDE
HHCCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCC
NLSPNITLGIHLHQNLNLAPSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANYL
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHEECCEEEECCCCCCCCCCCCHHHHHHHHHH
NQNFNHQYNIEKLLSLTALIEEFEILNRWGYNPIYMYSASLNIDRTYPEFFEKMGFCIEN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHCCCHHCC
NLNLQKICKEKGIGSKFNEEEAQKIINSYN
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCGVDFSIFNS
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
IDFVDQCLSTIEKKNSKFSLMLRTDRVDFNKLAKSPKVDFIRIALYQEHLNDIKRYGEKA
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
KELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLVDTFGSFTLNEFEKVLKIFDE
HHCCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCC
NLSPNITLGIHLHQNLNLAPSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANYL
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHEECCEEEECCCCCCCCCCCCHHHHHHHHHH
NQNFNHQYNIEKLLSLTALIEEFEILNRWGYNPIYMYSASLNIDRTYPEFFEKMGFCIEN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHCCCHHCC
NLNLQKICKEKGIGSKFNEEEAQKIINSYN
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA