Click here to switch to the map view.

The map label for this gene is hisA [H]

Identifier: 153951118

GI number: 153951118

Start: 1726870

End: 1727604

Strand: Direct

Name: hisA [H]

Synonym: JJD26997_1956

Alternate gene names: 153951118

Gene position: 1726870-1727604 (Clockwise)

Preceding gene: 153951018

Following gene: 153952109

Centisome position: 93.59

GC content: 33.88

Gene sequence:

>735_bases
ATGACTCAAATCATACCCGCACTTGATCTTATAGATGGCGAAGTAGTGCGTCTTGTAAAAGGGGATTATAAACAAAAAAA
AGTATATAAATACAATCCCTTAAAGAAATTTAAAGAATACGAAAAAGCAGGAGCGAAAGAACTTCATCTTGTAGATCTTA
CAGGTGCAAAAGATCCTAGCAAAAGACAACTTGTTTTGATAGAAAAATTAGCCAAAGAAGTCAGTGTCAATTTACAAGTA
GGTGGAGGCATACGCTCTAAAGAAGAAGTTAAAGCTTTGCTTGATTGTGGAGTAAAAAGAGTAGTGATAGGATCTATGGC
GATTAAAGATGCGACTTTATGTCTTGAAATTTTAAAAAAATTTGGTAGCGAAGCTATAGTTTTAGCCTTAGATACGATTT
TAAAAGAAGATTATGTTGTGGCTGTAAATGCTTGGCAAGAAGCAAGTGATAAAAAGCTTATGGAAGTTTTAGATTTTTAT
AGCAATAAAGGCTTAAAACACATACTTTGCACAGATATTTCAAAAGATGGCACCATGCAAGGAGTAAATGTAAGACTTTA
CAAACTTATCCATGAAATTTTTCCTAAGATTTGCATTCAGGCAAGTGGTGGAGTAGCGAGCTTAAAAGACCTTGAAAACT
TAAAAGGAATTTGTAGTGGGGTTATCGTAGGAAAAGCTTTATTAGACGGAGTTTTTAGTGTAGAAGAAGGGATAAGATGC
TTACAAAACGCATAA

Upstream 100 bases:

>100_bases
CAAGTGTAATGAAAGATAATTTTTACGGGGTGCAATTTCACCCTGAAAGAAGTAGTGAAGCGGGGGAAATTTTAATTTCA
AATTTTATTAAGGATATAGG

Downstream 100 bases:

>100_bases
TTGCATGTTTAGATGTCAAAGATGGCAGAGTAGTAAAAGGAACACAATTTAAAAACCATAAAGATATGGGAGATATCATA
GAACTTGCTAGGTATTATTC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQLVLIEKLAKEVSVNLQV
GGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFY
SNKGLKHILCTDISKDGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
LQNA

Sequences:

>Translated_244_residues
MTQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQLVLIEKLAKEVSVNLQV
GGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFY
SNKGLKHILCTDISKDGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
LQNA
>Mature_243_residues
TQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQLVLIEKLAKEVSVNLQVG
GGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYS
NKGLKHILCTDISKDGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRCL
QNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=51.2295081967213, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1788336, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26819; Mature: 26688

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPS
CCCCCCHHHHCCHHHHHHHHCCCHHCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
KRQLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKK
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQ
HCCCEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
CCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQNA
HHCC
>Mature Secondary Structure 
TQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPS
CCCCCHHHHCCHHHHHHHHCCCHHCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
KRQLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKK
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQ
HCCCEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
CCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQNA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA