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The map label for this gene is msrA [H]

Identifier: 153951089

GI number: 153951089

Start: 1204440

End: 1204937

Strand: Direct

Name: msrA [H]

Synonym: JJD26997_1362

Alternate gene names: 153951089

Gene position: 1204440-1204937 (Clockwise)

Preceding gene: 153951591

Following gene: 153951181

Centisome position: 65.28

GC content: 32.13

Gene sequence:

>498_bases
ATGAAAAATATCGTTTTAGGTGGCGGTTGTTTTTGGTGTGTTGAGGCCGTATTTGAACGCCTAAAAGGTGTAATCGATAC
TGAAGTTGGATATAGCGGAGGAAATCCAAATCCTAGCTACGAAAGCGTGTGCAATGGCGATGGTAATATAGAAGTTGTCA
AAATAAATTACGATGAAAAACAAATCCCTCTTCTTGAAATCTTAACACTCTTTTTTAAAATTCATGATCCAACAAGTATA
GATAAACAAGGTGCAGATATTGGCATACAATATCGCTCAATAATCTTTTACGAAAATGAAGAAGATAAAATTTTAGCTCA
AAATTTCATCGAAAAACAGCAAAAAATATTTAGTAAAAAAATAGTTACTCAAATTTCAAGATTGCAAACTTACTACAAAG
CCGAAAACTATCATCAACATTATTTTATGAATCATCCCGATCAAGGATATTGTCAAGCTGTAATAGCTCCAAAACTGCAA
AAAATACAATCAGACTAA

Upstream 100 bases:

>100_bases
AAAGATGAAAAAGTTGCAATTGAAATTTTAGAAAAGGCAATCAAAAACTACAAATAATTTAGCTCTTTAAAGGGCTAAAC
TCAAGGAAGGAAAACTCGCA

Downstream 100 bases:

>100_bases
TTTCATCTTTTTAAGTTTAAAAAAATTTCAACTTTATTCACAGCCTTTTCACGCTGTGATTTTCTTTTCAAAGTACTTAA
AAATAGAACTTTAAGCTTTA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEKQIPLLEILTLFFKIHDPTSI
DKQGADIGIQYRSIIFYENEEDKILAQNFIEKQQKIFSKKIVTQISRLQTYYKAENYHQHYFMNHPDQGYCQAVIAPKLQ
KIQSD

Sequences:

>Translated_165_residues
MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEKQIPLLEILTLFFKIHDPTSI
DKQGADIGIQYRSIIFYENEEDKILAQNFIEKQQKIFSKKIVTQISRLQTYYKAENYHQHYFMNHPDQGYCQAVIAPKLQ
KIQSD
>Mature_165_residues
MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEKQIPLLEILTLFFKIHDPTSI
DKQGADIGIQYRSIIFYENEEDKILAQNFIEKQQKIFSKKIVTQISRLQTYYKAENYHQHYFMNHPDQGYCQAVIAPKLQ
KIQSD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=41.8300653594771, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=41.8300653594771, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=38.562091503268, Blast_Score=111, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=34.4827586206897, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=38.3647798742138, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=34.375, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45553131, Length=156, Percent_Identity=34.6153846153846, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664631, Length=159, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18948; Mature: 18948

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEK
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCC
QIPLLEILTLFFKIHDPTSIDKQGADIGIQYRSIIFYENEEDKILAQNFIEKQQKIFSKK
CCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IVTQISRLQTYYKAENYHQHYFMNHPDQGYCQAVIAPKLQKIQSD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEK
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCC
QIPLLEILTLFFKIHDPTSIDKQGADIGIQYRSIIFYENEEDKILAQNFIEKQQKIFSKK
CCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IVTQISRLQTYYKAENYHQHYFMNHPDQGYCQAVIAPKLQKIQSD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA