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The map label for this gene is yclK [H]

Identifier: 153937775

GI number: 153937775

Start: 680319

End: 681389

Strand: Direct

Name: yclK [H]

Synonym: CLC_0663

Alternate gene names: 153937775

Gene position: 680319-681389 (Clockwise)

Preceding gene: 153936647

Following gene: 153934731

Centisome position: 18.09

GC content: 24.84

Gene sequence:

>1071_bases
ATGGATGGTAAAGCCGTAGTAGATTTGAAATATAGATATAATGGAGTAGATGCAATACTAACTTATCCTATATATATAGA
TAATGAATATGTGGGGATCATAAGCATAGTAAAGAATTATGACTCGAAATATAGGGATTATAAAAATACTATAAATATTA
TAAATATTATAGAACTTGGAACATTTATAGTTATATTTATATTTTTATTTTTAAGAACAAATAAAATTACTAAACCAATT
ACAGAATTAACAGATGCAATAAAAAAACTAGGATATGGTGATTATAATATTTCAATTGCTGAACATGGAAAAGATGAGGT
AGCAATATTAGCAAGAGAATTTATAAATATGAGAGATAAAATAAAAGAACAAATAGAAACTATTGAATCAGAAAAGAACA
AAGTTTATAAATTAGAAAAAGGAAGAAAGGAATTTTTTAATAGTGTAACCCATGAATTAAAAACACCATTGACAGCTATA
TCAGGATATGCTGAGTTACTACTTACAGGAATGGTCAAGGATAAAGACTTTGATAAAAGAGCTATTGAAAGAATATATTC
AGAAAGTGACAGGCTTCATAAGTTAGTATTAGATCTTATAGAGGTATCTAAAGGTATGTGTGTTATCAAAGAAGAACTTA
ATTATGTTGACATGAAAGAGCTTATTATTCAAAGTTGTAGTGATATGAATATAAAGGCTAATAAATATTCCTTAAAAATA
ATACAAAATATAAGTGAAGGAACAGTTAAGGTACAACAGGATAAAATTAGGCAAGTACTAATCAATATAATTGATAATGC
AATAAAATATTCCTATGGGGGAAATGAGATATATGTTAATTCTTACGTATCAGACAATAAATATATTATTGAAGTAATAA
ATAATAGTAATCCAATCCCAGATGAAATATTTAATAGTATATTTGAACCTTTTATAAAATCTAATAATGATAATAAAGAT
AGTAGAGGACTTGGTTTATATTTATGTAATGAAATAGTTAAAGAGCATGACGGTGAAATAACCATAGAAAATGGCTCTCT
AATAAAAGTAAAAATTCATTTAATAATTTAA

Upstream 100 bases:

>100_bases
ATGAATGCAAATGTGATATAAGAGATATAAATTATATATTGATAGAAGGAAATGTTCCAGAGGAATTCAGAAGCATAACA
AAAAAAGTAAAAAAGTAGCA

Downstream 100 bases:

>100_bases
AAATATGAAAAGCGCACTAATCTTCATGATATAGGTGCTTTTTATTTTTATTATTAATTTCTATATTAATTTGAAAAAAT
TTAATTTTAATAATTAATTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPI
TELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKEQIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAI
SGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKI
IQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKD
SRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII

Sequences:

>Translated_356_residues
MDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPI
TELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKEQIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAI
SGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKI
IQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKD
SRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
>Mature_356_residues
MDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPI
TELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKEQIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAI
SGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKI
IQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKD
SRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=24.2957746478873, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=24.3333333333333, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790861, Length=339, Percent_Identity=23.8938053097345, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=240, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=307, Percent_Identity=22.1498371335505, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=285, Percent_Identity=25.2631578947368, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=21.7910447761194, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=283, Percent_Identity=20.4946996466431, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=24.6808510638298, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788549, Length=204, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40987; Mature: 40987

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELG
CCCCEEEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIVIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
IKEQIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKR
HHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHH
AIERIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKI
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHCCCCCCEECCCEEEHH
IQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIP
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCH
DEIFNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEC
>Mature Secondary Structure
MDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELG
CCCCEEEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIVIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
IKEQIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKR
HHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHH
AIERIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKI
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHCCCCCCEECCCEEEHH
IQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIP
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCH
DEIFNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]