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The map label for this gene is icd [H]

Identifier: 153937746

GI number: 153937746

Start: 485619

End: 486617

Strand: Direct

Name: icd [H]

Synonym: CLC_0485

Alternate gene names: 153937746

Gene position: 485619-486617 (Clockwise)

Preceding gene: 153937020

Following gene: 153936994

Centisome position: 12.91

GC content: 32.23

Gene sequence:

>999_bases
ATGAAACACAATATAACTTTAATACCAGGAGATGGTATAGGACCAGAAGTAACTGAAGCTGCAAGGAAAGTTATAGATGC
AGTAGGAGCAGATATTAATTGGCATGTAGTAGAGGCGGGGGAAAAAGTTTTAGACAAATATAAAACCCCCCTTCCAGACT
ATGTTTTAGATAGTATAAAGGGGACTAAAGTAGCATTGAAGGGTCCAGTAACTACTCCTGTAGGAAAGGGATTTAGAAGT
GTTAATGTTACTTTAAGAAAAAGCTTAAATTTATATGCAAATATAAGACCTGTAAAGAGTTATAAAGGAATAAAATCTAG
ATATGAAAATGTGGATTTAATAATTGTGAGGGAAAACACAGAAGATTTATATGCGGGAATTGAACATATGATAGGTGATG
ATATAGCAGAAAGTATAAAGGTAATTACTAAAAAGGCTAGTGATAGAATAGTAGATTATGCTTTTGATATGGCAAGAAAA
GAAAATAGAAATAAGGTAACTGCAGTGCATAAAGCTAACATAATGAAATTATCAGATGGATTATTTTTAAATTGTGCAAA
GGAAGTTGCTAGTAAAAATAAGGATATTGATTTTGAAGATGTAATAGTAGATGCTATGGCCATGAAATTAGTTTTAAATC
CAGAAAAATATGATGTTTTAGTAATGCCTAATTTATATGGTGATATTTTATCAGACATGGCAGCAGGTTTAGTTGGGGGA
TTAGGATTACTTCCAGGAGCTAATATAGGATATGAAGGAGCTGTGTTTGAAGCAGCCCATGGTGCAGCACCTGATATTGC
AGGAAAAAATAAAGCTAATCCAACAGCTTGTATATTAAGTGGTGCCATGATGCTAAACTATATTGGTGAAAATGAAAAAG
CTAAAAAAATAGAAAATGCTATAGAAAAAGTATTTGTAGAAGGAAAATACCTTACAGAAGATTTAGGCGGAAGTTCTACA
ACAGAAGAATTTACAAAGGCAATTATAGAGAATCTTTAA

Upstream 100 bases:

>100_bases
ATAGACAAAAGAAGATGATTTTAAAGGGCGGATTATTAAATTTAATAAAAAGTTCTCAACAATAGCTACAAAAATTTAGT
TAAGTTTTCGGAGGGATATG

Downstream 100 bases:

>100_bases
ATTAGTATATAATTTTTAATTTGCTACTACTTTTCAATTAGATGTATAAATTTCAGGTCCCCTTTTATAATTACATTCAA
GTTTTTCTTATGATTTTAAG

Product: isocitrate/isopropylmalate family dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPDYVLDSIKGTKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKYLTEDLGGSST
TEEFTKAIIENL

Sequences:

>Translated_332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPDYVLDSIKGTKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKYLTEDLGGSST
TEEFTKAIIENL
>Mature_332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPDYVLDSIKGTKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKYLTEDLGGSST
TEEFTKAIIENL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=336, Percent_Identity=48.5119047619048, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=44.8377581120944, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI4758582, Length=334, Percent_Identity=42.5149700598802, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=44.5427728613569, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI28178838, Length=303, Percent_Identity=44.2244224422442, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI28178819, Length=200, Percent_Identity=50.5, Blast_Score=184, Evalue=8e-47,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=38.560411311054, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI87081683, Length=331, Percent_Identity=35.0453172205438, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788101, Length=361, Percent_Identity=32.409972299169, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71986051, Length=323, Percent_Identity=49.2260061919505, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI25144293, Length=336, Percent_Identity=41.0714285714286, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17505779, Length=333, Percent_Identity=41.1411411411411, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17550882, Length=338, Percent_Identity=39.9408284023669, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324709, Length=335, Percent_Identity=47.7611940298507, Blast_Score=329, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324291, Length=334, Percent_Identity=45.8083832335329, Blast_Score=290, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322097, Length=349, Percent_Identity=42.1203438395415, Blast_Score=248, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6319830, Length=358, Percent_Identity=32.6815642458101, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24643270, Length=328, Percent_Identity=53.9634146341463, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24643268, Length=328, Percent_Identity=53.9634146341463, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24661184, Length=334, Percent_Identity=48.502994011976, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI281362242, Length=337, Percent_Identity=44.8071216617211, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24648872, Length=337, Percent_Identity=44.8071216617211, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI161078637, Length=333, Percent_Identity=39.6396396396396, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161078635, Length=333, Percent_Identity=39.6396396396396, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI161078633, Length=333, Percent_Identity=39.6396396396396, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24650122, Length=333, Percent_Identity=39.6396396396396, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI161078639, Length=328, Percent_Identity=39.6341463414634, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI20130355, Length=333, Percent_Identity=35.4354354354354, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45550436, Length=247, Percent_Identity=25.9109311740891, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 36030; Mature: 36030

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPDYVLDSIK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHCCC
GTKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENT
CCEEEEECCCCCCCCCCCCEEEEEEEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECCC
EDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCC
LFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHH
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENA
HHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
IEKVFVEGKYLTEDLGGSSTTEEFTKAIIENL
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPDYVLDSIK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHCCC
GTKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENT
CCEEEEECCCCCCCCCCCCEEEEEEEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECCC
EDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCC
LFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHH
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENA
HHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
IEKVFVEGKYLTEDLGGSSTTEEFTKAIIENL
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]