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The map label for this gene is mfnA [H]

Identifier: 153937549

GI number: 153937549

Start: 2989295

End: 2990548

Strand: Direct

Name: mfnA [H]

Synonym: CLC_2824

Alternate gene names: 153937549

Gene position: 2989295-2990548 (Clockwise)

Preceding gene: 153936214

Following gene: 153936509

Centisome position: 79.49

GC content: 29.35

Gene sequence:

>1254_bases
ATGAAGTTTTGGAGAAAATATACTCACCAAGAAATGGATGAAAAAATAACTAAATCTTTAGAGAAAACTTTAAACTATGA
CAACACTAAAACTATAGGAATACCAGGAACTAAATTGGATGATACTGTTTTTTATGACGATCATAGTTTTGTAAAGCACT
CACCATATCTAAGAACATTTATACAAAATCCAAATCATATAGGGTGCCACACATATGATAAAGCAGATATATTATTCGGA
GGAACCTTTGATATAGAAAGAGAACTCATTCAATTATTAGCAATTGATGTTCTTAATGGAAATGATGAAGAATTCGATGG
ATATGTAACTCAGGGAGGAACCGAAGCTAATATACAAGCTATGTGGGTTTATAGAAATTATTTTAAAAAAGAAAGAAAAG
CAAAACATGACGAAATAGCTATAATCACATCTGCTGATACTCATTATTCAGCATATAAGGGATCTGATTTATTAAATATA
GATATAATAAAGGTTCCAGTAGATTTTTATAGCCGTAAAATTCAAGAGGACACTTTAGATAGCATTGTTAAAGAAGCTAA
AGAAATTGGGAAAAAATATTTTATAGTAATATCTAATATGGGGACTACAATGTTTGGCTCCGTAGATGATCCGGATTTAT
ATGCTAATATTTTTGATAAATATAATTTAGAATATAAAATTCATGTTGACGGAGCTTTCGGTGGATTCATATATCCTATA
AATAATAAAGAGTGTAAAACGGATTTTTCTAATAAAAATGTAAGCTCTATAACATTAGATGGTCATAAAATGTTGCAAGC
ACCCTATGGTACGGGAATTTTCGTGTGCAGGAAAAATTTAATACACAATACTCTTACAAAGGAAGCAACTTATATAGAGA
ATTTAGATGTTACACTAAGTGGTAGCCGTTCAGGTTCTAATGCTGTAGCTATATGGATGGTACTTGCTAGCTATGGACCA
TATGGATGGATGGAAAAGATAAATAAATTAAGAAATAGAACTAAATGGTTATGTAAGCAATTGAATGATATGGGAATTAA
ATATTACAAAGAGGACAGTATGAACATAGTAACTATAGAAGAACAATATGTTAATAAAGAAATAGCAGAAAAATACTTCC
TAGTACCAGAAGTTCATAACCCTACAAATAAATGGTATAAGATAGTCGTTATGGAACATGTTGAATTAGATATATTAAAT
TCCTTAGTATATGATTTAAGAAAATTCAATAAAGAACACTTAAAAGCAATGTAA

Upstream 100 bases:

>100_bases
CAAATTATATGTTATTATTATTTTGGAAAGTTTTTGAACTAAGAATACACTTGACAATCTCAATGTCGTGTTAAACATAA
CTAATAAGGGGGATTAATAA

Downstream 100 bases:

>100_bases
ATAATAAATAAGTTAAAAGGATACCAATAATATTTAAAGTGAACCCTTTGCCAAAGACATGAGAAAAAAAGTATGGCTAA
GACACCATTAAAAGCTGATT

Product: decarboxylase family protein

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKFWRKYTHQEMDEKITKSLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFG
GTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHDEIAIITSADTHYSAYKGSDLLNI
DIIKVPVDFYSRKIQEDTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPI
NNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVCRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGP
YGWMEKINKLRNRTKWLCKQLNDMGIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNKWYKIVVMEHVELDILN
SLVYDLRKFNKEHLKAM

Sequences:

>Translated_417_residues
MKFWRKYTHQEMDEKITKSLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFG
GTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHDEIAIITSADTHYSAYKGSDLLNI
DIIKVPVDFYSRKIQEDTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPI
NNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVCRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGP
YGWMEKINKLRNRTKWLCKQLNDMGIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNKWYKIVVMEHVELDILN
SLVYDLRKFNKEHLKAM
>Mature_417_residues
MKFWRKYTHQEMDEKITKSLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFG
GTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHDEIAIITSADTHYSAYKGSDLLNI
DIIKVPVDFYSRKIQEDTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPI
NNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVCRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGP
YGWMEKINKLRNRTKWLCKQLNDMGIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNKWYKIVVMEHVELDILN
SLVYDLRKFNKEHLKAM

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=297, Percent_Identity=25.5892255892256, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI197383062, Length=263, Percent_Identity=26.2357414448669, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI197276620, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4503875, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557272, Length=350, Percent_Identity=26.5714285714286, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17543922, Length=413, Percent_Identity=26.1501210653753, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25148342, Length=307, Percent_Identity=22.8013029315961, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555682, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71993058, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993062, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355963, Length=290, Percent_Identity=25.1724137931034, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24654344, Length=290, Percent_Identity=25.1724137931034, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356415, Length=285, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 48339; Mature: 48339

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFWRKYTHQEMDEKITKSLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCHHHCCHHHHHH
IQNPNHIGCHTYDKADILFGGTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQA
HCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEE
MWVYRNYFKKERKAKHDEIAIITSADTHYSAYKGSDLLNIDIIKVPVDFYSRKIQEDTLD
EEHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCEEEEEEEEECHHHHHHHHHHHHHH
SIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPI
HHHHHHHHCCCEEEEEEECCCCEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEC
NNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVCRKNLIHNTLTKEATYIENLDVTLS
CCCCCCCCCCCCCCEEEEECCHHHEECCCCCEEEEEEHHHHHHHHHHCHHEEECCEEEEE
GSRSGSNAVAIWMVLASYGPYGWMEKINKLRNRTKWLCKQLNDMGIKYYKEDSMNIVTIE
CCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEH
EQYVNKEIAEKYFLVPEVHNPTNKWYKIVVMEHVELDILNSLVYDLRKFNKEHLKAM
HHHCCHHHHHHEEECCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure
MKFWRKYTHQEMDEKITKSLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCHHHCCHHHHHH
IQNPNHIGCHTYDKADILFGGTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQA
HCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEE
MWVYRNYFKKERKAKHDEIAIITSADTHYSAYKGSDLLNIDIIKVPVDFYSRKIQEDTLD
EEHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCEEEEEEEEECHHHHHHHHHHHHHH
SIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPI
HHHHHHHHCCCEEEEEEECCCCEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEC
NNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVCRKNLIHNTLTKEATYIENLDVTLS
CCCCCCCCCCCCCCEEEEECCHHHEECCCCCEEEEEEHHHHHHHHHHCHHEEECCEEEEE
GSRSGSNAVAIWMVLASYGPYGWMEKINKLRNRTKWLCKQLNDMGIKYYKEDSMNIVTIE
CCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEH
EQYVNKEIAEKYFLVPEVHNPTNKWYKIVVMEHVELDILNSLVYDLRKFNKEHLKAM
HHHCCHHHHHHEEECCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA