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The map label for this gene is gcvPB [H]

Identifier: 153937289

GI number: 153937289

Start: 777170

End: 778624

Strand: Direct

Name: gcvPB [H]

Synonym: CLC_0753

Alternate gene names: 153937289

Gene position: 777170-778624 (Clockwise)

Preceding gene: 153934481

Following gene: 153934617

Centisome position: 20.67

GC content: 32.23

Gene sequence:

>1455_bases
ATGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAGACTTCCTAATTTAGATGTACC
AGAAGTAGAACTTTCAGAATTACTACCTAAAAACTTATTAAGAGAAGATGAAATAGAGCTTCCTGAGGTAAGTGAAGTTG
ATGTTGTAAGACACTATACAGCTCTTTCAAATAAAAATTATACTGTTGATAACGGATTTTATCCATTAGGATCATGCACT
ATGAAATATAATCCTAAAATAAATGAAGATATAGTTGCATTGAGCGGATTTTCAAAAATACATCCACTTCAAGATGAAAA
TATTTCACAGGGTGCATTAGAATTAATGTATGATTTAAAAGGTAAATTATGTGAAATTACAGGATTGGATGATTTTACTC
TTCAACCAGCAGCAGGTGCACATGGGGAGTATACTGGTCTTTTGATTATAAAAGCTTACCATGAAAAAAGAGGAGATACA
AAAAGAACAAAAATTATAGTTCCTGATTCAGCACATGGTACAAATCCTGCTAGTGCATCAGTAGCCGGATTTGACATTGT
AGAAATAAAATCTGGTGAAGATGGTAGGGTTTCTATTGAAGAACTTAAAAAAGTTTTAAATGATGAAATAGCAGGGCTAA
TGCTTACAAATCCAAGTACATTAGGATTATTTGAAAAAGACATAAAGCTCATAAGTGAGTTAGTTCATGAAGCCGGTGGA
TTATTATATTATGATGGAGCTAATCTAAATGCAATAATGGGAATTGCAAGGCCAGGGGATATGGGATTCGATGTATGCCA
CTTAAATATGCATAAAACATTCTCAACTCCACATGGTGGTGGTGGACCAGGATCAGGCCCTGTGGGAGTTAAAAAGCATT
TAGCTAAATTCCTTCCAGTACCAACAGTTGAAAAAGAAAATGATAAATTTATATTAGATTATAATAGACCAGATTCCCTT
GGAAAAATTAGAAGTTTATATGGAAACTTTGGTGTTATGGTTAAGGCATACACTTATATTTTAACAATGGGTAAGGAAGG
ATTAAAATCAGCTTCCCACAATGCTGTTTTAAATGCAAATTATATAAAAGAATCTTTAAGAGATTATTATAATATTGGAA
AAGATGATATTTGTAAACATGAGGTGATTTTAAGTACCCTTAAGGAAAATCCACATCATATAGCTACATTAGATATTGCA
AAGAGATTAATAGATTATGGTGTACATCCACCTACAGTTTATTTCCCATTAATAATTGAAGAGGCACTTATGATAGAGCC
TACTGAAAGTGAAAGTAAAGAGACTGTTGATGAATTTATAGATGCTATGAAAAAAATAGCTGTAGAAGCTAAAGAAAATC
CAGAACTTTTACATGAGGCACCAGTAAAAGCACCGGTAAGAAGATTAGACCAAGTAAAAGCAGCTAGAAAACCTATATTA
AGATGGCAAAAATAA

Upstream 100 bases:

>100_bases
AAGTTTACTCAGAGTATGAAAATTCTATGTTACTTTGTGTTACAGAGAAAAGGACAAGGGAAGATATAGATAATTTAGTA
AAAGTGATGGAGGCGATATA

Downstream 100 bases:

>100_bases
GTAAGGATATGTCTATGCAATCCAATATCATATAGTTTAGTGTATAAAATATAGATATAAATCCTAAAAATCTTACAACT
TTAGTCGTGAGAGGTTCAGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSELLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
RWQK

Sequences:

>Translated_484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSELLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
RWQK
>Mature_484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSELLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
RWQK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=410, Percent_Identity=42.6829268292683, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1789269, Length=475, Percent_Identity=40, Blast_Score=294, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=434, Percent_Identity=41.9354838709677, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI32564013, Length=393, Percent_Identity=42.2391857506361, Blast_Score=265, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=42.7586206896552, Blast_Score=315, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24645648, Length=415, Percent_Identity=42.1686746987952, Blast_Score=288, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53738; Mature: 53738

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSELLPKNLLREDEIELPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDIVALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCCCEEEECCCHHCCCCCCCCCCHHHHHHHHHHC
GKLCEITGLDDFTLQPAAGAHGEYTGLLIIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
CCEEEEECCCCCEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNRPDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKSASHNAVLNAN
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHCCCCCEEEEHH
YIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHC
RWQK
CCCC
>Mature Secondary Structure
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSELLPKNLLREDEIELPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDIVALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCCCEEEECCCHHCCCCCCCCCCHHHHHHHHHHC
GKLCEITGLDDFTLQPAAGAHGEYTGLLIIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
CCEEEEECCCCCEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNRPDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKSASHNAVLNAN
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHCCCCCEEEEHH
YIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHC
RWQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]