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The map label for this gene is serS-1

Identifier: 153937253

GI number: 153937253

Start: 22357

End: 23637

Strand: Direct

Name: serS-1

Synonym: CLC_0024

Alternate gene names: 153937253

Gene position: 22357-23637 (Clockwise)

Preceding gene: 153934720

Following gene: 153936471

Centisome position: 0.59

GC content: 29.59

Gene sequence:

>1281_bases
ATGTTAGATTTAAAAAGAATAAGAAATAATTCAAATGAAATAAAAGAATCATTAAACAATAGAGGAGAAAAGTTTGATGT
AACTGTAATTGATGAAGTCTTAAAATTAGATGAAGAAAGAAGAAATATTTTAGTTAAAGTTGAGGTTTTAAAAAGTAAGA
GAAATCAAGTTTCTTCTGAAGTTCCTAAACTAAAAAAAGAAGGAAAAGATGTATCTAATATAGTAGCTGAAATGAAAAAT
TTATCAGAAGAAATAAAAGGGTTTGATACTACTTTAGCTAAAATAGATGAAAAAATACAATATATAATGCTTAGAATACC
TAATATACCAAACCCACAAGTTCCAGATGGAGACACAGATGAGGATAATATAGAAATAAGAAATTGGTCAGAACCAACAA
AATTTGATTTTGAGCCTAAAGCACATTGGGATATAGGTTCAAATTTAAATATTCTTGATTTTGAAAGAGCTGGAAAAGTA
ACAGGATCAAGATTTACTTTTTATAAAGGATTAGGAGCTAGATTAGAAAGATCATTAATATCTTATTTTCTAGATACTCA
TACAGAGAAGCATGGCTACACTGAAATATTACCACCTTATATGGTGAATAGAACAAGTATGATAGGAACAGGACAATTAC
CTAAATTTGAAGAAGATGCTTTTAAAATTTCAGAGGATGATTACTTCTTAATACCAACTGCAGAGGTTCCTGTAACTAAT
TTATACAGAGATGAAATCTTAAAAGGTGATGAATTACCATTAAAACATGTAGCTTATAGTGCTTGTTTTAGATCAGAAGC
CGGTTCAGCAGGTAGAGATACAAGAGGTCTTGTTAGACAGCATCAATTCAATAAAGTAGAGCTTGTTAAATTTACAAAAC
CAGAACAGTCTTATGAAGAATTAGAAAAATTAACTAATGATGCTGAAACAGTATTAAAAGAGTTAGGTATTCCATATAGG
GTTGTAAGAATATGTAAAGGTGATTTAGGATTTACAGCTGCATTAAAATATGATTTAGAAGTTTGGATGCCAAGTTACAA
TAGATATGTTGAAATATCAAGCTGTAGTAACTTTGAAGACTTCCAAGCAAGACGTGCTAATATAAGATATAAAGAAGATG
CAAAAGCAAAACCACAATATGTTCATACATTAAATGGATCAGGAGTTGCTATTGGAAGAACTGTTGCAGCTATACTTGAA
AACTATCAAAATGAAGATGGATCAGTTACAATACCAGAAGTGTTAAGACCTTATATGGGAGGAAAAGAAGCAATAAAATA
G

Upstream 100 bases:

>100_bases
GTCCCTTTTATAGGGACGAGGGGCTTTTTTTATTATATTATAAAGCTATAAAATCTGAAGGGAGGAAGTATTTATTGGAT
AATCCAATAAATAAAATATT

Downstream 100 bases:

>100_bases
TTGAATATTATTTGTTATAAAGAATTTATATATATTTAATTTAAAATAAACACTATTAAATTAATTAATTATTATAAAAT
TTAATAGTGTTTTTATTATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDLKRIRNNSNEIKESLNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGDTDEDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKV
TGSRFTFYKGLGARLERSLISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQNEDGSVTIPEVLRPYMGGKEAIK

Sequences:

>Translated_426_residues
MLDLKRIRNNSNEIKESLNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGDTDEDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKV
TGSRFTFYKGLGARLERSLISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQNEDGSVTIPEVLRPYMGGKEAIK
>Mature_426_residues
MLDLKRIRNNSNEIKESLNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGDTDEDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKV
TGSRFTFYKGLGARLERSLISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQNEDGSVTIPEVLRPYMGGKEAIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=462, Percent_Identity=35.4978354978355, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=31, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI225579074, Length=403, Percent_Identity=30.5210918114144, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=48.3796296296296, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539260, Length=468, Percent_Identity=32.6923076923077, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=31.7460317460317, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321799, Length=432, Percent_Identity=34.2592592592593, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=33.9366515837104, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=32.2717622080679, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17737985, Length=358, Percent_Identity=32.9608938547486, Blast_Score=174, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CLOB1 (A7FQ53)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382425.1
- ProteinModelPortal:   A7FQ53
- SMR:   A7FQ53
- STRING:   A7FQ53
- GeneID:   5396351
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0022
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- BioCyc:   CBOT441770:CLB_0022-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48752; Mature: 48752

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKRIRNNSNEIKESLNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGDTD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKVTGSRFTFYKGLGARLERSLI
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQNEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GKEAIK
CHHCCC
>Mature Secondary Structure
MLDLKRIRNNSNEIKESLNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGDTD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKVTGSRFTFYKGLGARLERSLI
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQNEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GKEAIK
CHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA