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The map label for this gene is rnc [H]

Identifier: 153937224

GI number: 153937224

Start: 2432512

End: 2433216

Strand: Reverse

Name: rnc [H]

Synonym: CLC_2303

Alternate gene names: 153937224

Gene position: 2433216-2432512 (Counterclockwise)

Preceding gene: 153937784

Following gene: 153934827

Centisome position: 64.7

GC content: 29.36

Gene sequence:

>705_bases
TTGAAAAATAGACAGGATGTTTTAAAAGAACTTCAGTATAAACTTAAAGTATATTTTAAAAATGAAAAGTTATTAGATGT
GGCATTAACTCATAGTTCCTATGCTAATGGTAAAAAAAATATAAAATATTATGAAAGATTGGAGTTCTTGGGAGATTCCG
TATTGCAGCTTATAATATCAGAGCATTTATATCAAAAATATGAAGATAAAAAAGAAGGAGAGCTTACAAGGAAGAGAGCT
ATAATAGTTTGCGAAAATTCTCTTTATGAAATAGCTAAAAGATGGGATTTAGGTTTTTATCTACAAATGAGTAAAGGGGA
AGAATTAACAGGAGGCAGAGAAAGGGTATCTATATTAGCAGATTGTGTAGAGTCTATAATAGCTGCTATATATTTAGATA
AAGGATTAGATCATGCGAGAGAATTTGTTATGAAAAATTTCAAAGAAATAATAGAAAAAGCTATGAAAGATGAAATAATA
TTAGATTACAAAACTACATTGCAAGAAATAGTGCAACAAAATAATGATCTCACTATAAACTATGAATTATTAAAACAGGA
AGGTCCTCCTCACAGAAGAAGGTTCTTTACTAATGTAACCATAGATAATGAGGTAAGAGGAACTGGAATAGGCTATAGTA
AAAAAGAAGCAGAACAAAACGCAGCAAGAGAAGCATTAAAGAATTTAGGTGATAGCCATGAGTAA

Upstream 100 bases:

>100_bases
CCCCGCCTTTATTAGCGGGGATTTTATATTAAAAGATAAGTTTATTCTTGAGTTTATTTAATAAATACACTGAAGAATGA
ACTTCTAGGGAGTGAAAATT

Downstream 100 bases:

>100_bases
AAGCCATTATATAATACCAATATTCGTTGCTCAGGAAGGATGTCCACATAATTGTGTTTTTTGTAATCAATATAAAATAA
CCGGGGAAAAGGATGAAATG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKNRQDVLKELQYKLKVYFKNEKLLDVALTHSSYANGKKNIKYYERLEFLGDSVLQLIISEHLYQKYEDKKEGELTRKRA
IIVCENSLYEIAKRWDLGFYLQMSKGEELTGGRERVSILADCVESIIAAIYLDKGLDHAREFVMKNFKEIIEKAMKDEII
LDYKTTLQEIVQQNNDLTINYELLKQEGPPHRRRFFTNVTIDNEVRGTGIGYSKKEAEQNAAREALKNLGDSHE

Sequences:

>Translated_234_residues
MKNRQDVLKELQYKLKVYFKNEKLLDVALTHSSYANGKKNIKYYERLEFLGDSVLQLIISEHLYQKYEDKKEGELTRKRA
IIVCENSLYEIAKRWDLGFYLQMSKGEELTGGRERVSILADCVESIIAAIYLDKGLDHAREFVMKNFKEIIEKAMKDEII
LDYKTTLQEIVQQNNDLTINYELLKQEGPPHRRRFFTNVTIDNEVRGTGIGYSKKEAEQNAAREALKNLGDSHE
>Mature_234_residues
MKNRQDVLKELQYKLKVYFKNEKLLDVALTHSSYANGKKNIKYYERLEFLGDSVLQLIISEHLYQKYEDKKEGELTRKRA
IIVCENSLYEIAKRWDLGFYLQMSKGEELTGGRERVSILADCVESIIAAIYLDKGLDHAREFVMKNFKEIIEKAMKDEII
LDYKTTLQEIVQQNNDLTINYELLKQEGPPHRRRFFTNVTIDNEVRGTGIGYSKKEAEQNAAREALKNLGDSHE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=29.2035398230088, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=29.2035398230088, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788920, Length=228, Percent_Identity=35.9649122807018, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=30.2222222222222, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=30.2222222222222, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137682, Length=239, Percent_Identity=28.4518828451883, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27336; Mature: 27336

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRQDVLKELQYKLKVYFKNEKLLDVALTHSSYANGKKNIKYYERLEFLGDSVLQLIIS
CCCHHHHHHHHHHHHHEEECCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EHLYQKYEDKKEGELTRKRAIIVCENSLYEIAKRWDLGFYLQMSKGEELTGGRERVSILA
HHHHHHHCCHHHHHHHHHHEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
DCVESIIAAIYLDKGLDHAREFVMKNFKEIIEKAMKDEIILDYKTTLQEIVQQNNDLTIN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCEEEE
YELLKQEGPPHRRRFFTNVTIDNEVRGTGIGYSKKEAEQNAAREALKNLGDSHE
EEEECCCCCCHHHHEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNRQDVLKELQYKLKVYFKNEKLLDVALTHSSYANGKKNIKYYERLEFLGDSVLQLIIS
CCCHHHHHHHHHHHHHEEECCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EHLYQKYEDKKEGELTRKRAIIVCENSLYEIAKRWDLGFYLQMSKGEELTGGRERVSILA
HHHHHHHCCHHHHHHHHHHEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
DCVESIIAAIYLDKGLDHAREFVMKNFKEIIEKAMKDEIILDYKTTLQEIVQQNNDLTIN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCEEEE
YELLKQEGPPHRRRFFTNVTIDNEVRGTGIGYSKKEAEQNAAREALKNLGDSHE
EEEECCCCCCHHHHEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]