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The map label for this gene is ddc [H]

Identifier: 153936946

GI number: 153936946

Start: 277738

End: 279162

Strand: Direct

Name: ddc [H]

Synonym: CLC_0299

Alternate gene names: 153936946

Gene position: 277738-279162 (Clockwise)

Preceding gene: 153937185

Following gene: 153937683

Centisome position: 7.39

GC content: 33.19

Gene sequence:

>1425_bases
ATGGATATAAATTTAAAGAATGATTTAGAGAATATTGATATTTTATTAGAAAAAGTAACAATTAACGCGTTTGATTTTTT
AAAAGATATTAATGAAATAGCGACTTTCCCCAAAAGTACAAATGCTTATACACTTTCTCAATTAAACAAAGATGGGTTAG
GTGGAGAAAAAACATTAGAAGAGTTTATGCAAAGATTTTATAAGGGAATAGTTTCATGTGCAGGATCAAAGTATTTTGGT
TTTGTAACTGGAGGGACAACTACAGCAGCTTTGATGGGTGACTGGTTAGTGAGTACATTTGATCAAAATGCCACAGGTAG
AGATACTTCTAGTGCAGCAAAGCTTGAGGAAGAAACCATAAATTTATTAAAGCAGCTTTTAGTATTGCCAGAAACATATT
CGGGAACCTTTGTAACCGGAGCTACTATGGCTAACTTTGTGGGCTTAGCAATTGGAAGGCAGTGGCTAGCTAATGAATTA
GGCGTTAACATAGCTATAGATGGTCTGTATTCTATTCCGCCAATAAGAATTGTAAGTTCTACTCCTCATTCAAGCATTTT
AAAAGCTTTGTCTATGCTAGGCATGGGGAGAAAAAATATGCATTATATTCCTACGATTGATGGAAGAGAGGCTATAGATG
TTGAAGCATTAGAAAGTTATTTAAAAAAGTTGAATGGAGAACCATGTATTGTTGTAGCAAATGCAGGAACAGTAAATACT
GTTGATTTTGATGATTTAAAACAAATTGGAGAATTAAAAGAAAAATATAACTTTTTTCTCCATGTAGATGGAGCTTTTGG
AGGTTTTGCTTCTTGTTCAATAAAGTACAAAAAACTTGTAGAAGGAATTGAAGCAGCAGATTCTATTACCATAGATGCGC
ATAAGTGGCTAAATGTTCCTTATGATAGTGCAATGCAGTTCACTAAACATCCTAAACTTCAGATTCAAGTTTTTCAAAAC
AACGCAGTATATCTAGGCGAGCTTTCAGATAAGCCTGATTTTGTTCATTTAACTCCAGAAAATTCAAGAAGGTTAAGGGC
TCTTCCTGCATGGTTTACCCTAAAGGCATATGGACAAAATGGATATCAGGAGATAATTGAGAGAAACTGTAATCTAGCAC
AATTGCTAAGTAAAAAAATTGATGAATCTAAAAATTTTAGTTTATTGTCAACTACTAGACTAAATGTAGTTTGCTTCACC
ATTAATCTCGAGAATGATAATGTTAATTTAGAGCAAATACAGCAATTTTTAAATTTAGTTAATAAGGATGGCAGAGCATT
CTTTACTCAAACAGTATATAAAGGAATAGCAGGAATAAGGGCAGCTATAAGCAATTGGAGGACAGAGGAAAAAGATATTG
AAATCGCATGGGAAGTACTAAATAAGGCATATGAGTCCTATTATGAAACAATAACAGTAGATTGA

Upstream 100 bases:

>100_bases
AGGGATCGTATTCAACTATTAAGATTGATTATATATAATATGATACATATACTATATCACAATATTAAGTTACAAAGAAA
ACCATGAAAGGAGTATATCT

Downstream 100 bases:

>100_bases
TATAGAAAAGTATTTTACAAGTTTTCAAACAGGTAAAAATTTAAAGAAACTTAAGGTTTTTCTAGTGTTAAGCACTATTT
TTAGATTTTTATATGTATTA

Product: putative amino acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDINLKNDLENIDILLEKVTINAFDFLKDINEIATFPKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYKGIVSCAGSKYFG
FVTGGTTTAALMGDWLVSTFDQNATGRDTSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSILKALSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKEKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAMQFTKHPKLQIQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFSLLSTTRLNVVCFT
INLENDNVNLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNKAYESYYETITVD

Sequences:

>Translated_474_residues
MDINLKNDLENIDILLEKVTINAFDFLKDINEIATFPKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYKGIVSCAGSKYFG
FVTGGTTTAALMGDWLVSTFDQNATGRDTSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSILKALSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKEKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAMQFTKHPKLQIQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFSLLSTTRLNVVCFT
INLENDNVNLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNKAYESYYETITVD
>Mature_474_residues
MDINLKNDLENIDILLEKVTINAFDFLKDINEIATFPKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYKGIVSCAGSKYFG
FVTGGTTTAALMGDWLVSTFDQNATGRDTSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSILKALSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKEKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAMQFTKHPKLQIQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFSLLSTTRLNVVCFT
INLENDNVNLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNKAYESYYETITVD

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=413, Percent_Identity=24.6973365617433, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI132814448, Length=413, Percent_Identity=24.6973365617433, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI92110055, Length=463, Percent_Identity=23.7580993520518, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI197383062, Length=401, Percent_Identity=26.1845386533666, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI197276620, Length=432, Percent_Identity=23.6111111111111, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4503875, Length=432, Percent_Identity=23.6111111111111, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI58331246, Length=403, Percent_Identity=26.0545905707196, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI194294551, Length=353, Percent_Identity=24.6458923512748, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI190341074, Length=252, Percent_Identity=28.1746031746032, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534817, Length=462, Percent_Identity=23.5930735930736, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17534819, Length=462, Percent_Identity=23.5930735930736, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71993062, Length=330, Percent_Identity=25.7575757575758, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17555682, Length=330, Percent_Identity=25.7575757575758, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71993058, Length=330, Percent_Identity=25.7575757575758, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981217, Length=300, Percent_Identity=25.3333333333333, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71981211, Length=300, Percent_Identity=25.3333333333333, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17551992, Length=284, Percent_Identity=25.7042253521127, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI133931025, Length=239, Percent_Identity=25.1046025104602, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17543922, Length=297, Percent_Identity=22.5589225589226, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221476190, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585143, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585139, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652373, Length=479, Percent_Identity=26.3048016701461, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136594, Length=353, Percent_Identity=27.7620396600567, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573972, Length=415, Percent_Identity=26.2650602409639, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136190, Length=460, Percent_Identity=22.6086956521739, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24586044, Length=456, Percent_Identity=22.3684210526316, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585135, Length=235, Percent_Identity=25.9574468085106, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356415, Length=295, Percent_Identity=27.7966101694915, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24657193, Length=330, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24657185, Length=330, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24657188, Length=330, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52946; Mature: 52946

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINLKNDLENIDILLEKVTINAFDFLKDINEIATFPKSTNAYTLSQLNKDGLGGEKTLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCCCCCHHHHH
EFMQRFYKGIVSCAGSKYFGFVTGGTTTAALMGDWLVSTFDQNATGRDTSSAAKLEEETI
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
NLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANELGVNIAIDGLYSIPPIRIVSS
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCEEEEEC
TPHSSILKALSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
CCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEC
VDFDDLKQIGELKEKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVP
CCHHHHHHHHHHHHHCEEEEEECCCCCCCHHCCEEHHHHHHHHHHCCCEEEEHHHHCCCC
YDSAMQFTKHPKLQIQVFQNNAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQN
HHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCEEEECCCCCCCEEECCCEEEEEECCCC
GYQEIIERNCNLAQLLSKKIDESKNFSLLSTTRLNVVCFTINLENDNVNLEQIQQFLNLV
HHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHH
NKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNKAYESYYETITVD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MDINLKNDLENIDILLEKVTINAFDFLKDINEIATFPKSTNAYTLSQLNKDGLGGEKTLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCCCCCHHHHH
EFMQRFYKGIVSCAGSKYFGFVTGGTTTAALMGDWLVSTFDQNATGRDTSSAAKLEEETI
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
NLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANELGVNIAIDGLYSIPPIRIVSS
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCEEEEEC
TPHSSILKALSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
CCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEC
VDFDDLKQIGELKEKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVP
CCHHHHHHHHHHHHHCEEEEEECCCCCCCHHCCEEHHHHHHHHHHCCCEEEEHHHHCCCC
YDSAMQFTKHPKLQIQVFQNNAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQN
HHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCEEEECCCCCCCEEECCCEEEEEECCCC
GYQEIIERNCNLAQLLSKKIDESKNFSLLSTTRLNVVCFTINLENDNVNLEQIQQFLNLV
HHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHH
NKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNKAYESYYETITVD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]