Click here to switch to the map view.

The map label for this gene is mtaD [H]

Identifier: 153936940

GI number: 153936940

Start: 2263914

End: 2265266

Strand: Reverse

Name: mtaD [H]

Synonym: CLC_2131

Alternate gene names: 153936940

Gene position: 2265266-2263914 (Counterclockwise)

Preceding gene: 153936179

Following gene: 153935610

Centisome position: 60.24

GC content: 32.59

Gene sequence:

>1353_bases
ATGAATCAAATTTTAATAAAAAATGGTTATATTATTACAATGGATTGTTCAAAGAGAATATTTGAGAAAGGTGATATTTT
AGTTGAGGATTCTAAAATTATTGCTATAGGTAATGTGGAATCTGAATTAATTAAATCTAATGTTGAAATTATAGATGCTA
ATGGAAAAATCATAATGCCTGGTTTAGTAAATACCCATGTGCATTTATCTCAACAATTAGCTAGAGGATTAGCTGACGAT
GTAGATCTTTTAACTTGGCTTCGCAAACGTATATGGCCTTACGAAAGCAATATGGATTTAGAGGATTCTTATATTTCTTC
ACTAGCCTGTTGTACAGAACTAATACGTTCAGGTGTTACTACTTTTTGTGAAGCTGGTGGACAAGAAGTAGATGGCATGG
GAAAAGCCGTAGAAGAAGCAGGACTTAGAGGTATTCTTTGTCGCTCTACTATGGATTGTGGTGATGGTTTACCATTAAAA
TGGCAAGAAACCACAGAGGAATCTTTACAAAAACAAGTAGAGTTACTTGAAAGGTGGAATGGTAAAGGAGATGGACGTAT
TAAGTATTGGTTTGGCTTAAGAACTATTTTTAATACTACAGATAAATTAATAACTAAAACTAAAGAACTAGCAGATAAAT
ATAAAGTAGGTATTCATATGCATGTTGCTGAAATAGAAGAGGAAGTTAGATATGCAGAAGCAACTCGTGGTGAAACCACT
GTTCAGCATTTAGCTAAATTAGGGGTATTAGATAAAAACTTTTTAGCTGTACATACAGTATGGCTTACAGAACAAGAAAT
TGATTTATTTAAGCTTCATAATGTAAAAGTATCCCATAATCCTGGTGCTGCAATGAAAGTTGTTTTAGGTTTTGCACATA
TTCCAGAAATGCTTGAAAAAGGAATCAATGTTTCAATTGGAACTGATGGTGCTCCTTCTAATAATAGAATGGATATGTTT
GATGAAATGCATTTAACCTCATTAATACATAAAGGTAGAAGATTGAATCCAAAGGTTGTTCCTGCTGATGAAGTATTAGA
AATGGCTACAATGAATGGTGCTAAATGTGCCCTTTGGGAGGATGAAATAGGTTCTTTGGAGGTAGGAAAAAAAGCAGATT
TAATAATAATTAACCCTAAATCCATTGGCAGTCTTCCTATGCATGATCCAATTGGAAATATAGTATATTCAATGCACTCT
AGTGATGTAGAATCTTCTATGTGTAATGGTAAGTGGTTAATGAAGAATAAAGTATTATTAACTATAGATGAAGAGGATAT
TATTAGAGAAGCACAGGAAAAAGCAACAGCTTTAGTTAAAAAAGCAGGTATTGTCTTACCAAAACGTTTTTAA

Upstream 100 bases:

>100_bases
AAACTCCCTCTGAAGCTTAGAACTATGTTTATATTTAAGTTTTACTAAGTTTCATTGAATTATATATATATAAATAGAGA
TAGATAAAGGAGAATATATT

Downstream 100 bases:

>100_bases
AAATAGAAAGAATCATCTTTAATCTAGTAATTATAGTTTAAGGATGATTCTAATATTTTTGAAAAAATTTATATATTGAT
TAACATAGGTATAATTTATT

Product: amidohydrolase domain-containing protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNQILIKNGYIITMDCSKRIFEKGDILVEDSKIIAIGNVESELIKSNVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEEAGLRGILCRSTMDCGDGLPLK
WQETTEESLQKQVELLERWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFAHIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTIDEEDIIREAQEKATALVKKAGIVLPKRF

Sequences:

>Translated_450_residues
MNQILIKNGYIITMDCSKRIFEKGDILVEDSKIIAIGNVESELIKSNVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEEAGLRGILCRSTMDCGDGLPLK
WQETTEESLQKQVELLERWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFAHIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTIDEEDIIREAQEKATALVKKAGIVLPKRF
>Mature_450_residues
MNQILIKNGYIITMDCSKRIFEKGDILVEDSKIIAIGNVESELIKSNVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEEAGLRGILCRSTMDCGDGLPLK
WQETTEESLQKQVELLERWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFAHIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTIDEEDIIREAQEKATALVKKAGIVLPKRF

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=344, Percent_Identity=27.0348837209302, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082177, Length=449, Percent_Identity=25.6124721603563, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789249, Length=375, Percent_Identity=27.7333333333333, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24643849, Length=427, Percent_Identity=21.0772833723653, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50211; Mature: 50211

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQILIKNGYIITMDCSKRIFEKGDILVEDSKIIAIGNVESELIKSNVEIIDANGKIIMP
CCCEEEECCEEEEECCCHHHHHCCCEEEECCEEEEECCCHHHHHHCCCEEEECCCCEEEC
GLVNTHVHLSQQLARGLADDVDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
TFCEAGGQEVDGMGKAVEEAGLRGILCRSTMDCGDGLPLKWQETTEESLQKQVELLERWN
HHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCHHH
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFAHIPEMLEK
HHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GINVSIGTDGAPSNNRMDMFDEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWE
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
DEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHSSDVESSMCNGKWLMKNKVLL
CCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCEEEEECCEEE
TIDEEDIIREAQEKATALVKKAGIVLPKRF
EECHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNQILIKNGYIITMDCSKRIFEKGDILVEDSKIIAIGNVESELIKSNVEIIDANGKIIMP
CCCEEEECCEEEEECCCHHHHHCCCEEEECCEEEEECCCHHHHHHCCCEEEECCCCEEEC
GLVNTHVHLSQQLARGLADDVDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
TFCEAGGQEVDGMGKAVEEAGLRGILCRSTMDCGDGLPLKWQETTEESLQKQVELLERWN
HHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCHHH
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFAHIPEMLEK
HHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GINVSIGTDGAPSNNRMDMFDEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWE
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
DEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHSSDVESSMCNGKWLMKNKVLL
CCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCEEEEECCEEE
TIDEEDIIREAQEKATALVKKAGIVLPKRF
EECHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA