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The map label for this gene is ipk

Identifier: 153936778

GI number: 153936778

Start: 151231

End: 152073

Strand: Direct

Name: ipk

Synonym: CLC_0169

Alternate gene names: 153936778

Gene position: 151231-152073 (Clockwise)

Preceding gene: 153935877

Following gene: 153935672

Centisome position: 4.02

GC content: 27.76

Gene sequence:

>843_bases
ATGTTATCAAAAGCTCATGCTAAAATAAATTTATCCTTAGACGTAATAGGAAAAAGAAAAGACGGATATCACCTTTTAAA
GATGTTAATGCAAACCATAGATTTATATGATCTAATAGAAATAAAAAAAATAAAAAAAGATATAATAATAGATTGTGATA
GAGAGTATATACCTAAAGATAGGAGAAATTTGGCATATAAAGCAGCAACCCTATTTTTAGATAGATACAATATAGATTCT
GGAGTTAGAATAAACATAACTAAAAATATACCAGTAGCAGCAGGATTAGCAGGGGGAAGCACAGATGCGGCTACAGTATT
GAAAATAATGAGAGATATATTTGAGCCAGACATAAGTAATGAAGAATTAAAAGAGATAGCTTTAGATATTGGGGCAGATG
TGCCGTTTTGTATAGAAGGTGGGACAGCTCTTTGTGAAGGTATAGGAGAAAAAATTACTCCCATAAAAAATTTTAAAAAT
CACATATTAGTATTAGTTAAACCTAATTTTGGGTTATCTACAAAAGATGTATACAATAATTTAAAAGTAGAAAAAATATA
TATTCATCCTAATACAACAAAATTAATACAATCAATAGAAGAAGATAATTTGAAATCTGTAGCTAGAAATATGAGGAATG
TCTTAGAAAATGTTACATTAAGAAAATATAAGGCATTAAATTCTATAAAAAGTAATTTTATAGAGTTAGGAGCATTAGGA
AGTATGATGAGTGGTAGCGGACCAAGTGTATTTGGATTATTTGATGATATGCTAAAGGCTCAAATATGTTATGACAATAT
GAGAGAAAAGTATAAAGAAGTATTTATAACAAGAACAATATAA

Upstream 100 bases:

>100_bases
TAGCATAGGATTAAAGCTACAATTTATGAATATCATGATTGTAGCTTTAATTTTTTTGATGTATTATATATTCTATAATA
TATATTTTTGGAGGAATAAA

Downstream 100 bases:

>100_bases
TAGTTAAAAGACCATAGAAATATATTTTAAGAATTATTTATATGGTCTTTTTTTTATTATCTTACTAGTTGTACATAAAG
CTAAAGTTTTTACTTAAATG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MLSKAHAKINLSLDVIGKRKDGYHLLKMLMQTIDLYDLIEIKKIKKDIIIDCDREYIPKDRRNLAYKAATLFLDRYNIDS
GVRINITKNIPVAAGLAGGSTDAATVLKIMRDIFEPDISNEELKEIALDIGADVPFCIEGGTALCEGIGEKITPIKNFKN
HILVLVKPNFGLSTKDVYNNLKVEKIYIHPNTTKLIQSIEEDNLKSVARNMRNVLENVTLRKYKALNSIKSNFIELGALG
SMMSGSGPSVFGLFDDMLKAQICYDNMREKYKEVFITRTI

Sequences:

>Translated_280_residues
MLSKAHAKINLSLDVIGKRKDGYHLLKMLMQTIDLYDLIEIKKIKKDIIIDCDREYIPKDRRNLAYKAATLFLDRYNIDS
GVRINITKNIPVAAGLAGGSTDAATVLKIMRDIFEPDISNEELKEIALDIGADVPFCIEGGTALCEGIGEKITPIKNFKN
HILVLVKPNFGLSTKDVYNNLKVEKIYIHPNTTKLIQSIEEDNLKSVARNMRNVLENVTLRKYKALNSIKSNFIELGALG
SMMSGSGPSVFGLFDDMLKAQICYDNMREKYKEVFITRTI
>Mature_280_residues
MLSKAHAKINLSLDVIGKRKDGYHLLKMLMQTIDLYDLIEIKKIKKDIIIDCDREYIPKDRRNLAYKAATLFLDRYNIDS
GVRINITKNIPVAAGLAGGSTDAATVLKIMRDIFEPDISNEELKEIALDIGADVPFCIEGGTALCEGIGEKITPIKNFKN
HILVLVKPNFGLSTKDVYNNLKVEKIYIHPNTTKLIQSIEEDNLKSVARNMRNVLENVTLRKYKALNSIKSNFIELGALG
SMMSGSGPSVFGLFDDMLKAQICYDNMREKYKEVFITRTI

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=270, Percent_Identity=31.8518518518519, Blast_Score=105, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_CLOB1 (A7FQF0)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382528.1
- ProteinModelPortal:   A7FQF0
- SMR:   A7FQF0
- STRING:   A7FQF0
- GeneID:   5397710
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0157
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   VSTKEVY
- ProtClustDB:   PRK00128
- BioCyc:   CBOT441770:CLB_0157-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31520; Mature: 31520

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKAHAKINLSLDVIGKRKDGYHLLKMLMQTIDLYDLIEIKKIKKDIIIDCDREYIPKD
CCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCH
RRNLAYKAATLFLDRYNIDSGVRINITKNIPVAAGLAGGSTDAATVLKIMRDIFEPDISN
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCH
EELKEIALDIGADVPFCIEGGTALCEGIGEKITPIKNFKNHILVLVKPNFGLSTKDVYNN
HHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHCC
LKVEKIYIHPNTTKLIQSIEEDNLKSVARNMRNVLENVTLRKYKALNSIKSNFIELGALG
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMMSGSGPSVFGLFDDMLKAQICYDNMREKYKEVFITRTI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MLSKAHAKINLSLDVIGKRKDGYHLLKMLMQTIDLYDLIEIKKIKKDIIIDCDREYIPKD
CCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCH
RRNLAYKAATLFLDRYNIDSGVRINITKNIPVAAGLAGGSTDAATVLKIMRDIFEPDISN
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCH
EELKEIALDIGADVPFCIEGGTALCEGIGEKITPIKNFKNHILVLVKPNFGLSTKDVYNN
HHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHCC
LKVEKIYIHPNTTKLIQSIEEDNLKSVARNMRNVLENVTLRKYKALNSIKSNFIELGALG
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMMSGSGPSVFGLFDDMLKAQICYDNMREKYKEVFITRTI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA