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The map label for this gene is malX [H]

Identifier: 153936612

GI number: 153936612

Start: 309638

End: 311161

Strand: Direct

Name: malX [H]

Synonym: CLC_0327

Alternate gene names: 153936612

Gene position: 309638-311161 (Clockwise)

Preceding gene: 153937334

Following gene: 153935092

Centisome position: 8.23

GC content: 31.1

Gene sequence:

>1524_bases
ATGAGCAAAAAAAATAAAATAATGGATTTCTTCTCTGCCTTAGGTAGAAGTTTAATGTTACCAATTGCTACTTTAGCTGC
TGCAGGTTTAATATTAGGTCTAAGTTCTGCACTACTTAAACCACAAATTCAAGCAGCATTACCTTTTTTACAAAATTCAG
TGGGTGTATATGTTTTAACTTTAATTAAAACGATTACTGCTACAGTTTTTGGAATGATTCCAGTATTATTTGCTATATGT
ATTGCTTTTGGATTAGCAAAAGAAGAAAAAGAGATTGCGGCATTTGCAGGATTCATTGGTTATTATACATTTTTATTAAG
TGCATCAATTATTATTAATTCCGGAGCATTTAACTTTGCTTCACTTAAAATGTCAAATATTTTAGGCATTGAGAAAACCA
TAGAAATGGGAGCTTTTGCAGGTATCCTTACAGGTATATTAACATCAATGCTTCATAATAAATTTTATAAAATTGACTTC
CCTATAGCTATTGCTTTTTATGGTGGAAAGAGATTTGTAGCAATTGTAGTTATAGGAGCCATGACCCTTCTTGGACAAGT
TATGCCATTTGTTTGGGTTCCAATTTCATCAGGAATAAATTCTTTAGGAAGTTTAATTGCAAGTTCAGGACATACAGGTG
TATTTTTGTTTGGATTCTTAGAAAGAATTTTGATTCCTACCGGACTACACCATGTTTTAAATGGTGTATTTCGTACAACA
TCTGTAGGTGGAGTATATCAAGGAGTGGAAGGATGTTTAAACATATTCCTTCAATTCTTTGATAAGGTAGATATTTCTCA
ATTAAAACAATTTACAGCCTTCTTAGGACAAGGCAAAATGCCATTTATGATGTTTGGACTTCCAGCAGCAGCCTATGCTA
TATATAAGACATCCCCTGATAATAAGAAGCCTAAAGTAAAGGCTCTAATGGTTGCAGGAGTTGCTGCATCTATTGTATCA
GGAATTACAGAACCATTAGAATTCTCATTTATGTTTATTGCTCCACAACTATTCTTATTCCATGCTATAATGGGAGGTAT
TTCTTTTGGTATATTAAGTTTACTAGGTGTTGCAATTGGAAATACTGGTGGAGGAATTATTGATTTCTTGATTTATGGAG
TTTTAGTACCTGGATCAAGATGGTATATTGTAATATTAGTAGGTATAGTATTTGCAGTTATTTATTATATGGTATTTAAG
TGGTATTTCACAAATAAGAATATTTCTATTGATGTAAATGAAGATGTTGAAGAAGAAGATTTTTCCAAAGATTCATCTGG
AAAAACTAATTTAGCTGTCAAAATTATTAATGGATTAGGTGGAATTGATAATATAGTAGCAGTTAACAATTGTATCTCAA
GACTTAGAGTAGATATTAAAGATATGTCATTAGTAAATGAAGATTTATTAAAGAAAACTGGCAGTATGGGAATTGTGAAA
CCTTCTTCAACTCATATACATGTTATTTATGGACCTAAAGTTGAAAAAGTAGCAAAGCAAGTAAAAGAAGCTATGAAATA
TTAA

Upstream 100 bases:

>100_bases
TTATATTTAGAATTTTTAGAAAAATCTCCATATTCATGCAATTTAAAGAGATTTAGAATATTGAAATATTACAAATGTTT
AATTAAAAAGGAGAATGTGT

Downstream 100 bases:

>100_bases
ATTATATAAATATAAAAATAGCAACTTAAAATGATGCTATTTTTATAAATCTAATGCGAAACAATATTCATACGTGACAT
ATATAATTCTATAATTATTT

Product: PTS system, maltose/glucose-specfic, IIBC component

Products: NA

Alternate protein names: Maltose and glucose permease IIC component; PTS system maltose- and glucose-specific EIIC component; Maltose- and glucose-specific phosphotransferase enzyme IIB component; PTS system maltose- and glucose-specific EIIB component [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSKKNKIMDFFSALGRSLMLPIATLAAAGLILGLSSALLKPQIQAALPFLQNSVGVYVLTLIKTITATVFGMIPVLFAIC
IAFGLAKEEKEIAAFAGFIGYYTFLLSASIIINSGAFNFASLKMSNILGIEKTIEMGAFAGILTGILTSMLHNKFYKIDF
PIAIAFYGGKRFVAIVVIGAMTLLGQVMPFVWVPISSGINSLGSLIASSGHTGVFLFGFLERILIPTGLHHVLNGVFRTT
SVGGVYQGVEGCLNIFLQFFDKVDISQLKQFTAFLGQGKMPFMMFGLPAAAYAIYKTSPDNKKPKVKALMVAGVAASIVS
GITEPLEFSFMFIAPQLFLFHAIMGGISFGILSLLGVAIGNTGGGIIDFLIYGVLVPGSRWYIVILVGIVFAVIYYMVFK
WYFTNKNISIDVNEDVEEEDFSKDSSGKTNLAVKIINGLGGIDNIVAVNNCISRLRVDIKDMSLVNEDLLKKTGSMGIVK
PSSTHIHVIYGPKVEKVAKQVKEAMKY

Sequences:

>Translated_507_residues
MSKKNKIMDFFSALGRSLMLPIATLAAAGLILGLSSALLKPQIQAALPFLQNSVGVYVLTLIKTITATVFGMIPVLFAIC
IAFGLAKEEKEIAAFAGFIGYYTFLLSASIIINSGAFNFASLKMSNILGIEKTIEMGAFAGILTGILTSMLHNKFYKIDF
PIAIAFYGGKRFVAIVVIGAMTLLGQVMPFVWVPISSGINSLGSLIASSGHTGVFLFGFLERILIPTGLHHVLNGVFRTT
SVGGVYQGVEGCLNIFLQFFDKVDISQLKQFTAFLGQGKMPFMMFGLPAAAYAIYKTSPDNKKPKVKALMVAGVAASIVS
GITEPLEFSFMFIAPQLFLFHAIMGGISFGILSLLGVAIGNTGGGIIDFLIYGVLVPGSRWYIVILVGIVFAVIYYMVFK
WYFTNKNISIDVNEDVEEEDFSKDSSGKTNLAVKIINGLGGIDNIVAVNNCISRLRVDIKDMSLVNEDLLKKTGSMGIVK
PSSTHIHVIYGPKVEKVAKQVKEAMKY
>Mature_506_residues
SKKNKIMDFFSALGRSLMLPIATLAAAGLILGLSSALLKPQIQAALPFLQNSVGVYVLTLIKTITATVFGMIPVLFAICI
AFGLAKEEKEIAAFAGFIGYYTFLLSASIIINSGAFNFASLKMSNILGIEKTIEMGAFAGILTGILTSMLHNKFYKIDFP
IAIAFYGGKRFVAIVVIGAMTLLGQVMPFVWVPISSGINSLGSLIASSGHTGVFLFGFLERILIPTGLHHVLNGVFRTTS
VGGVYQGVEGCLNIFLQFFDKVDISQLKQFTAFLGQGKMPFMMFGLPAAAYAIYKTSPDNKKPKVKALMVAGVAASIVSG
ITEPLEFSFMFIAPQLFLFHAIMGGISFGILSLLGVAIGNTGGGIIDFLIYGVLVPGSRWYIVILVGIVFAVIYYMVFKW
YFTNKNISIDVNEDVEEEDFSKDSSGKTNLAVKIINGLGGIDNIVAVNNCISRLRVDIKDMSLVNEDLLKKTGSMGIVKP
SSTHIHVIYGPKVEKVAKQVKEAMKY

Specific function: MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system [H]

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787908, Length=522, Percent_Identity=39.463601532567, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1787343, Length=507, Percent_Identity=31.163708086785, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786894, Length=514, Percent_Identity=33.4630350194552, Blast_Score=228, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR004719
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- InterPro:   IPR011535
- InterPro:   IPR011301 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 54750; Mature: 54619

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKNKIMDFFSALGRSLMLPIATLAAAGLILGLSSALLKPQIQAALPFLQNSVGVYVLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHH
LIKTITATVFGMIPVLFAICIAFGLAKEEKEIAAFAGFIGYYTFLLSASIIINSGAFNFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
SLKMSNILGIEKTIEMGAFAGILTGILTSMLHNKFYKIDFPIAIAFYGGKRFVAIVVIGA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCHHHHHHHHHH
MTLLGQVMPFVWVPISSGINSLGSLIASSGHTGVFLFGFLERILIPTGLHHVLNGVFRTT
HHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SVGGVYQGVEGCLNIFLQFFDKVDISQLKQFTAFLGQGKMPFMMFGLPAAAYAIYKTSPD
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHEEEECCCC
NKKPKVKALMVAGVAASIVSGITEPLEFSFMFIAPQLFLFHAIMGGISFGILSLLGVAIG
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTGGGIIDFLIYGVLVPGSRWYIVILVGIVFAVIYYMVFKWYFTNKNISIDVNEDVEEED
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHH
FSKDSSGKTNLAVKIINGLGGIDNIVAVNNCISRLRVDIKDMSLVNEDLLKKTGSMGIVK
CCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
PSSTHIHVIYGPKVEKVAKQVKEAMKY
CCCCEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKNKIMDFFSALGRSLMLPIATLAAAGLILGLSSALLKPQIQAALPFLQNSVGVYVLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHH
LIKTITATVFGMIPVLFAICIAFGLAKEEKEIAAFAGFIGYYTFLLSASIIINSGAFNFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
SLKMSNILGIEKTIEMGAFAGILTGILTSMLHNKFYKIDFPIAIAFYGGKRFVAIVVIGA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCHHHHHHHHHH
MTLLGQVMPFVWVPISSGINSLGSLIASSGHTGVFLFGFLERILIPTGLHHVLNGVFRTT
HHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SVGGVYQGVEGCLNIFLQFFDKVDISQLKQFTAFLGQGKMPFMMFGLPAAAYAIYKTSPD
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHEEEECCCC
NKKPKVKALMVAGVAASIVSGITEPLEFSFMFIAPQLFLFHAIMGGISFGILSLLGVAIG
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTGGGIIDFLIYGVLVPGSRWYIVILVGIVFAVIYYMVFKWYFTNKNISIDVNEDVEEED
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHH
FSKDSSGKTNLAVKIINGLGGIDNIVAVNNCISRLRVDIKDMSLVNEDLLKKTGSMGIVK
CCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
PSSTHIHVIYGPKVEKVAKQVKEAMKY
CCCCEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 2670898 [H]