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The map label for this gene is cobD [H]

Identifier: 153936585

GI number: 153936585

Start: 995433

End: 996521

Strand: Direct

Name: cobD [H]

Synonym: CLC_0970

Alternate gene names: 153936585

Gene position: 995433-996521 (Clockwise)

Preceding gene: 153936192

Following gene: 153937295

Centisome position: 26.47

GC content: 25.9

Gene sequence:

>1089_bases
ATGCATGGTGGAGATATTTATACAGAGGGAATTTTAAAGGGAAAAGAACTTATAGATTTTAGTTCTAATATAAATCCTCT
AGGGTTGCCAGACAGTTTTAAAGATAATTTACAGGAAGCCCTAAATTGGGTACAAGTTTATCCAGATATTCAGTATAGAA
ACCTAAAAAGAAATTTAATAGACTATTTAAGTTTTTCTCTAGGCTATTTTTATAAAGAAAAAGTAGAGAAACCTAATATA
AAGGAAGAAAATTTGGTTCTAGGTAATGGAGCAGTAGAAATAATCGATTTAGCCATAAGCAATTTAAAGAGTATATCTAT
TTTAGTACCTTCCTTTGTGGAATATGAATTATGTGCTAAAAAATGGAATGTACAAATAGATTATTGCAATTTAAATGAGG
ATATGACATATAACTATGAAAATATAAAAAAATCCTTAGAAAAAACAGAAGGAATAATATTGGGAAATCCTAATAATCCT
AATGGATCAGTAATAGATAAGGAAGAGTTTATATACATACTAGATTACTGCGACAAAAATAATAAAATTATAATTTTAGA
TGAAGCTTTTATAGAGTTTACAGGAAAGAATTCCTTTAGTTTTTTAAACTTATGCGAAAGATACAAGTGTATTTTTATAA
TAAGAGCTTTAACTAAGTTTTTTTCTATGCCAGGCATAAGATTTGGTTATGGAATAAGTTTTAATAATGAATTTTTAAAT
AAAATAAGGGAAAAGCAAAACCCCTGGAATATAAATTGCTTTGCAGAAATTGCAGTTAAATATGTTTTAAAGGATGAAGA
TTTCATAGAAAAGTCCATAAATTATATAGAAAAAGAAAAAATATTTATGCATGAGAATCTAAAAAAATGTGATTTGTTTC
ATAGTGTATATAGTACTTACAGCAATTTTGTACTTTGTAAGTTAAAGGATATTACAGGAGATGAGCTTAAAAATAGGCTT
TTAGAGAAAGGATTTGCTCTAAGGGTTTGCAAGGATTTTAAAAATTTAAATAATAATTATGTAAGATTTGCAATAAAAAC
TAGAGAACTTAATCAGGCTTTAGTAAATATTTTAAAGGAAATAAAGTAA

Upstream 100 bases:

>100_bases
AAAACTTTAGAAGTTAAAAATTTATATAAGTTTTTAAGGTAATGAAAAATTATAACCTTAATTCTTAATTCGCAATTGTT
TAAAATAAGGTGGTGTTTAT

Downstream 100 bases:

>100_bases
AAGAAAATTTCATTTAAAGTGAAGAATTATTTCATAAAATGAGTAGTTAGTTTTAAAACTAAGAATCGTTGTATAAAATA
TATAACTGTTTTTAAAGCAA

Product: aminotransferase family protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLQEALNWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVEKPNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCDKNNKIIILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEDFIEKSINYIEKEKIFMHENLKKCDLFHSVYSTYSNFVLCKLKDITGDELKNRL
LEKGFALRVCKDFKNLNNNYVRFAIKTRELNQALVNILKEIK

Sequences:

>Translated_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLQEALNWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVEKPNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCDKNNKIIILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEDFIEKSINYIEKEKIFMHENLKKCDLFHSVYSTYSNFVLCKLKDITGDELKNRL
LEKGFALRVCKDFKNLNNNYVRFAIKTRELNQALVNILKEIK
>Mature_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLQEALNWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVEKPNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCDKNNKIIILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEDFIEKSINYIEKEKIFMHENLKKCDLFHSVYSTYSNFVLCKLKDITGDELKNRL
LEKGFALRVCKDFKNLNNNYVRFAIKTRELNQALVNILKEIK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=289, Percent_Identity=23.1833910034602, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=25.3298153034301, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42303; Mature: 42303

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLQEALNWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCCHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLGYFYKEKVEKPNIKEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNPNGSVIDKEEFIYILDYCDKN
HCCEEEEEEECCCCCEECHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIIILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KIREKQNPWNINCFAEIAVKYVLKDEDFIEKSINYIEKEKIFMHENLKKCDLFHSVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SNFVLCKLKDITGDELKNRLLEKGFALRVCKDFKNLNNNYVRFAIKTRELNQALVNILKE
CCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHH
IK
CC
>Mature Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLQEALNWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCCHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLGYFYKEKVEKPNIKEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNPNGSVIDKEEFIYILDYCDKN
HCCEEEEEEECCCCCEECHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIIILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KIREKQNPWNINCFAEIAVKYVLKDEDFIEKSINYIEKEKIFMHENLKKCDLFHSVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SNFVLCKLKDITGDELKNRLLEKGFALRVCKDFKNLNNNYVRFAIKTRELNQALVNILKE
CCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHH
IK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]