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The map label for this gene is folK [H]

Identifier: 153935832

GI number: 153935832

Start: 910754

End: 911209

Strand: Direct

Name: folK [H]

Synonym: CLC_0885

Alternate gene names: 153935832

Gene position: 910754-911209 (Clockwise)

Preceding gene: 153935059

Following gene: 153937375

Centisome position: 24.22

GC content: 27.85

Gene sequence:

>456_bases
ATGCATACAGTTTATGTGGCCTTTGGGAGTAATATAGGTGAAAAAGAAAGTTACATAAAAAGGGCATTGGAAAAGATAGA
AGAAAGAGGAATGGAAATAATTAAAGTATCCTCTATATATGAAACAGAACCCTATGGAGTATTAGATCAAGATAGTTTTT
TAAATGGAGTAGTAAAAATAGAAACTAATTTAACTCCAGAAGATTTAATAGGGGAGCTTTTAAACATAGAAAAACAGTTA
AATAGAGTAAGAGAAAGAAGATGGGGACCTAGAACTATAGATTTAGATATTATTTTTTATGATGATTTAATAATAAATGA
AAAAGATTTAGTTATTCCTCATAAGGATATGGAAAACAGAGAGTTTGTATTAAAGCCTTTGTGTGATATAGATGAAAATT
TTATACATCCGGTTTTAAAAAAATCAGTAAGAGAATTGTATGATGAGTTGAAGTAA

Upstream 100 bases:

>100_bases
ATAAATATAAATTTCTATTTATTAAAGAGTTTTAAAAAGATGAGAGTATTATAAATAAAATATAAACATATATAGAAAAT
CCTTAAGGAAGTGATAATAT

Downstream 100 bases:

>100_bases
ATATTTCTAGTTTATTATTATTATATTCCTCTAATAATAATTATATAGCTTGATACTATATTAATGGTTAATATAAAAGG
AACAAAACACCTAAATTAAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MHTVYVAFGSNIGEKESYIKRALEKIEERGMEIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
NRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRELYDELK

Sequences:

>Translated_151_residues
MHTVYVAFGSNIGEKESYIKRALEKIEERGMEIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
NRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRELYDELK
>Mature_151_residues
MHTVYVAFGSNIGEKESYIKRALEKIEERGMEIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
NRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRELYDELK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=41.726618705036, Blast_Score=115, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=158, Percent_Identity=42.4050632911392, Blast_Score=117, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 17752; Mature: 17752

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTVYVAFGSNIGEKESYIKRALEKIEERGMEIIKVSSIYETEPYGVLDQDSFLNGVVKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCHHHHCCEEEE
ETNLTPEDLIGELLNIEKQLNRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENR
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCEEECCCCCCCC
EFVLKPLCDIDENFIHPVLKKSVRELYDELK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTVYVAFGSNIGEKESYIKRALEKIEERGMEIIKVSSIYETEPYGVLDQDSFLNGVVKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCHHHHCCEEEE
ETNLTPEDLIGELLNIEKQLNRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENR
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCEEECCCCCCCC
EFVLKPLCDIDENFIHPVLKKSVRELYDELK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]