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The map label for this gene is dtpA [H]

Identifier: 153935824

GI number: 153935824

Start: 2095139

End: 2096485

Strand: Reverse

Name: dtpA [H]

Synonym: CLC_1975

Alternate gene names: 153935824

Gene position: 2096485-2095139 (Counterclockwise)

Preceding gene: 153935564

Following gene: 153935050

Centisome position: 55.75

GC content: 35.41

Gene sequence:

>1347_bases
ATGGAAAACACAAATAAAAAACCATTTGGGTTCTATGTATGTTCAGTTGCTTTCACACTTGAAAGATTTGCATTCTACTC
AGCAAAATGGTTACTTGCAGTATTTGTAGTTGCTAAGATAGCTGATGGAGGACTTGGTCTTTCTGCTGCAGATGCAGCAA
AGATGTCCGCAAACTTAGTTGCATTTACTTATGCTGCACCATTAATTGGAGCTATTATATCCGACCGTTTTATAGGAGCT
AGATACCTTGTTCCAATCGGAATGGTTTTAATGGGGGCAGGTTATTTAGTAGGATGGCAAGCTTCAAGTGCTGGCATGGT
TAACTTAATGATTGTACTAGTTTCTCTTGGTACAGGGTTATTTAAATGTCAAACAAACGCTATTACAGGTAGACTTTTCG
ATGATCCAAGAGAATTAGACAGTGCATTCTCTATTCAATATTCTTTTGTTAATATTGGTTCTTTCATTGGTACAACAATT
ATCGGTGTACTTGTAGGGACTAAGGGATATGCTTTCTGTTTCTTAGTTTGTGGAATAATGATGTTTATTGATGCCGCTTG
GTTTACTTTTGGATGGAGATTTTTAGGAGAAACAGGTAAAAAGCCATTTAAAATTGATGAGCATAAAGAAGTAAAAGCGA
AAGAAACTAAGGAAGAAAAGAAACCACTTACATCAATAGAAAAGAAAAGGGTTGCAGCAATTATATTAGTATCTTTCTTT
TCAGTAATTTTCTGGGTATTCTGGTATTTAGCATATATGCCTGTATATTTCTATTGGGGTGGAGACAATGCAGCGGCTAA
CTGGATGATAGGTAACTTTCAAGTTCCAACAGCTTGGTTTGATTCATTAAATGCATTAGCATGTATCTCACTTGGACCAA
TTCTTGGTAAGGTATGGTCAAAATTAGCTAAGAGACCTCAAGGTGATCTAAGTATGTTTAAGAAAACTGCTTTAGGTATG
ATACTTTTAGGTTTATCCTATGTAATCTTTGCAATGGCAGATGTTACAAGAGGCGGAAGCCTTGCACCACTTGCTTGGAT
TATTGCATTTGGTATTGTATTATCTTTAGGTGAAATGGTATTCTCACCACTTGGAAACTCTTTCATTAGTAAATTTTCAC
CACCTAAATTATTATCAAGTATGATGAGTGTTTGGGTACTTGCTGTTTTCTTTGCAGCAAAATCTTATGGATGGGTATAT
GAATTTACACTAAAATTTAAATTCGCACCAACATACTTTGTAATAGCTGCTATTGCTGCTGGAGCAGGTATCATTCTTTG
GTTATTAGATGGAAAATTGAATAGCTTAGTTGTAGAAGAGGAAGAACCATTAAACGAAGCTGTTTAA

Upstream 100 bases:

>100_bases
ATGGTATTTGAAATCATTTCATCTCATCTTGAAAAAGGGGAGAAAATATGGTTTTTGAAATACACACGCAATATTAATCT
TTTTATAGGGGGAATAAAAA

Downstream 100 bases:

>100_bases
GCAGGTAACAAATTATTATTCATATAAAAGTTTATAAAAAAAGAAGTCATTGTTTACAATGGCTTCTTTTTTTATAACTT
TTTATTTTCACAATTGTTGA

Product: amino acid/peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MENTNKKPFGFYVCSVAFTLERFAFYSAKWLLAVFVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGA
RYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPRELDSAFSIQYSFVNIGSFIGTTI
IGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEHKEVKAKETKEEKKPLTSIEKKRVAAIILVSFF
SVIFWVFWYLAYMPVYFYWGGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKTALGM
ILLGLSYVIFAMADVTRGGSLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVY
EFTLKFKFAPTYFVIAAIAAGAGIILWLLDGKLNSLVVEEEEPLNEAV

Sequences:

>Translated_448_residues
MENTNKKPFGFYVCSVAFTLERFAFYSAKWLLAVFVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGA
RYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPRELDSAFSIQYSFVNIGSFIGTTI
IGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEHKEVKAKETKEEKKPLTSIEKKRVAAIILVSFF
SVIFWVFWYLAYMPVYFYWGGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKTALGM
ILLGLSYVIFAMADVTRGGSLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVY
EFTLKFKFAPTYFVIAAIAAGAGIILWLLDGKLNSLVVEEEEPLNEAV
>Mature_448_residues
MENTNKKPFGFYVCSVAFTLERFAFYSAKWLLAVFVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGA
RYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPRELDSAFSIQYSFVNIGSFIGTTI
IGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEHKEVKAKETKEEKKPLTSIEKKRVAAIILVSFF
SVIFWVFWYLAYMPVYFYWGGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKTALGM
ILLGLSYVIFAMADVTRGGSLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVY
EFTLKFKFAPTYFVIAAIAAGAGIILWLLDGKLNSLVVEEEEPLNEAV

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787922, Length=426, Percent_Identity=24.8826291079812, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789911, Length=443, Percent_Identity=23.7020316027088, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786927, Length=433, Percent_Identity=23.094688221709, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790572, Length=427, Percent_Identity=22.0140515222482, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 49105; Mature: 49105

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEEEEEECCCCCCEEECCCCCCCCCC
>Mature Secondary Structure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CCCEEEEEECCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]