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The map label for this gene is tipA [H]

Identifier: 153935434

GI number: 153935434

Start: 912088

End: 913440

Strand: Direct

Name: tipA [H]

Synonym: CLC_0887

Alternate gene names: 153935434

Gene position: 912088-913440 (Clockwise)

Preceding gene: 153937375

Following gene: 153937040

Centisome position: 24.25

GC content: 25.72

Gene sequence:

>1353_bases
ATGAAAAATACCTCAAAAAAATTATTTACCACAGGAGAATTTGCTAAAAAAGCTGGAGTAACCATAAGGACTTTAAGATA
TTATGACAAAATAGGGTTATTAGTTCCCAGTAGCCATAATGAATTAGGGCATAGATTGTACAGCAAAGAGGACTTTGGTA
AACTACAAAAGATATTAACTCTTAAATTTATAGGGCTTTCCCTAGAGGATATAGCTAATATAATGAAGTATGATTTGAAT
CATAAAGATTTTAAAAAGTCTTTAGAAATTCAAAAGGAAATAATGAAGAAAAAAATAAAGCATATACAATCTATTATAAA
AGCTATAGATGAAGCTGCGGATACCATAGATTTTAATAAAGAAATGGATTGGGATAAGTTTATAAATATAATAAGTGCCA
TAAATTCTGATAAAAATTGGACTCAGCAATATGAAAATGCATCAAACTTAAGGGCAAGAATAGCTATTCATGAACTTTTT
AGTACAAATAAAGAAGGTTGGATGTCCTGGTTTTTTAAAGAACTAAAACATGAATTAAGTAGGATAAGTTCAAACTGTCA
AAATTATAATGAGAAGATAAATAATACTAATATGTCAGGACTAAACAGCTTAGATTGTAAAAATAATAATGAGAAAATAG
ATAATTATAATGCATCAGAATTAAATAGCTTAGATTTAAAGGAAACTTCTAATATAAAGATATTAGAGCTAGGTTGTGGT
GATGCTAGTCTTTGGAATAAAAATTTTAATCATATACCCTCAAATTGGGAAATAACATTAACAGATTTTTCAGAAGGCAT
GCTAAAGGACGCTAAAAAAAATTTAAGGGAAAAAAGAAGTAGATTTAATTTTAAAATTGTAAATGCAGAAAATATTCCTT
TTGAAGAGGAAAGTTTCAATGTAGTTATAGCAAATCATATGCTTTATCATGTGCCTAATATAAATAAAGCTTTAAAAGAA
ATAAATAGAGTATTGAAAAGTGAGGGGATTTTATTTGCCTCCACTGTTGGTAAAAATCACATGAAAGAAATAAGAGAAAT
AATTTCTACATTTGATATATATAATTTAACCAGTGAAAGCTGGGAAATTACAGATAGTTTTCAATTAGAAAATGGATTAA
AAATTGTATCAGAATATTTTAATATGGTAGAATTGAAAAGATATAAAGACAATTTAAAGGTGACAGATCCTGTATATATA
TTAGACTATATATTTTCTATGCCAGGAAATAATAAAGTAAATTTATCTTCAAAGGATTTAAAAAAGATTTATGATTATTT
AGAAGATAATATAAAAGAAAAAGAAAATATTTACATAACAAAGGATACGGGATATTTTAAAGGTAAAAAATAA

Upstream 100 bases:

>100_bases
TATACTTATCTAGGTGTGTAGCAAGGCTTAGCTTCTGTTTCGATAAAAAGATTGAAGCTAAGTAAACATGATATGATATA
TTATTGTAGAGGTGATTAAT

Downstream 100 bases:

>100_bases
ATAAAAATTATTTTAAAATAAAAAATCAATTGTTAAATGAAGGGAAGGATTATAATGAAAAAGATACCATTTTCACCACC
AGATATTACAGAAAGAGAGA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKNTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMSWFFKELKHELSRISSNCQNYNEKINNTNMSGLNSLDCKNNNEKIDNYNASELNSLDLKETSNIKILELGCG
DASLWNKNFNHIPSNWEITLTDFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKE
INRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYI
LDYIFSMPGNNKVNLSSKDLKKIYDYLEDNIKEKENIYITKDTGYFKGKK

Sequences:

>Translated_450_residues
MKNTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMSWFFKELKHELSRISSNCQNYNEKINNTNMSGLNSLDCKNNNEKIDNYNASELNSLDLKETSNIKILELGCG
DASLWNKNFNHIPSNWEITLTDFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKE
INRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYI
LDYIFSMPGNNKVNLSSKDLKKIYDYLEDNIKEKENIYITKDTGYFKGKK
>Mature_450_residues
MKNTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMSWFFKELKHELSRISSNCQNYNEKINNTNMSGLNSLDCKNNNEKIDNYNASELNSLDLKETSNIKILELGCG
DASLWNKNFNHIPSNWEITLTDFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKE
INRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYI
LDYIFSMPGNNKVNLSSKDLKKIYDYLEDNIKEKENIYITKDTGYFKGKK

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 52505; Mature: 52505

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILT
CCCCCCHHEECHHHHHHCCCEEEEHHHHHHHCEEECCCCCHHHHHHHCHHHHHHHHHHHH
LKFIGLSLEDIANIMKYDLNHKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNK
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELFSTNKEGWMSWFFKELKHELS
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RISSNCQNYNEKINNTNMSGLNSLDCKNNNEKIDNYNASELNSLDLKETSNIKILELGCG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEEEECCC
DASLWNKNFNHIPSNWEITLTDFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFN
CHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
VVIANHMLYHVPNINKALKEINRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSES
EEEECCEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
WEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDL
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCHHHH
KKIYDYLEDNIKEKENIYITKDTGYFKGKK
HHHHHHHHHCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKNTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILT
CCCCCCHHEECHHHHHHCCCEEEEHHHHHHHCEEECCCCCHHHHHHHCHHHHHHHHHHHH
LKFIGLSLEDIANIMKYDLNHKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNK
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELFSTNKEGWMSWFFKELKHELS
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RISSNCQNYNEKINNTNMSGLNSLDCKNNNEKIDNYNASELNSLDLKETSNIKILELGCG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEEEECCC
DASLWNKNFNHIPSNWEITLTDFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFN
CHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
VVIANHMLYHVPNINKALKEINRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSES
EEEECCEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
WEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDL
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCHHHH
KKIYDYLEDNIKEKENIYITKDTGYFKGKK
HHHHHHHHHCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]